Xia Yang Lab UCLA
@YangLabUCLA
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Integrative #Genomics and #SystemsBiology of Common Metabolic Disorders and Comorbidity
Los Angeles, CA
Joined June 2018
Congratulations to Dr. David Ulmert @davidulmert and team for the promising new LRRC15-targeting radionuclide therapy for aggressive, treatment-resistant tumors!
uclahealth.org
UCLA scientists, together with a team of international collaborators, have identified a promising new treatment strategy that can detect, kill and reprogram aggressive, treatment-resistant tumors...
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Excited to share our latest work in @CellReports highlighting a PPARγ-dependent remodeling of translation machinery in adipose progenitors. Amazing collab between our lab @ClaudioVillanu @YangLabUCLA and @LauraHulea
@CellPressNews @uclaibp
cell.com
De Siqueira et al. explore the effects of rosiglitazone on adipose stem cell plasticity, showing that PPARγ stimulates expression of ribosomal factors in adipocyte precursors. This leads to transla...
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The paradoxical effects of fish oil on cardiovascular risk shown in https://t.co/141r6pg8G1 reminds me of our similar findings on DHA on brain transcriptome/epigenome/cognition/metabolism - it compromises or protects depending on health or disease state:
bmjmedicine.bmj.com
Objective To examine the effects of fish oil supplements on the clinical course of cardiovascular disease, from a healthy state to atrial fibrillation, major adverse cardiovascular events, and...
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Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out the full agenda for our Single Cell Genomics Day on Friday, 3/29. All talks will be live-streamed (no registration required) at https://t.co/KJpeGwWLIr
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Free Cell Press webinar, Lessons from multiomic & transcriptional analyses in cancer & complex disease w/ speakers Anna Seung Nam @AnnaEnim @WeillCornell, Elisa Oricchio @elisa_oricchio @EPFL & Xia Yang @UCLA @YangLabUCLA. March 13, 12:00 pm ET. https://t.co/FY7Z8VHSd0
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The scientist who persevered—despite all these challenges and many more—to transform medicine ✓ Threatened to be deported ✓ Demoted ✓ Dismissed ✓ Grants systematically rejected ✓ Seminal paper rejected by leading journals
If you're not familiar with @kkariko—and her life- changing discovery against all odds, recognized by the 2023 @NobelPrize, you'll be inspired by this conversation. The new Ground Truths podcast (link in profile) Now available @apple and @Spotify
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We are thankful for this Insight preview article by Dr. Arya Mani from Yale: “Genetics: From mouse to human” https://t.co/Byf2mk4xNb about our new eLife article: https://t.co/VZRCEAoIeJ!
elifesciences.org
A deep analysis of multiple genomic datasets reveals which genetic pathways associated with atherosclerosis and coronary artery disease are shared between mice and humans.
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Matt Damon makes a better case for academic tenure than I’ve ever heard https://t.co/2zn26RcLZm
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Our new study is out in @eLife: “Shared and distinct pathways and networks genetically linked to coronary artery disease between human and mouse” https://t.co/H7tkEj48J8 Thanks to the team led by @zeynebkurt @MontyBlencowe and collaborators Drs. Jake Lusis and @JohanBjorkegren!
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This is unbelievable! Kurt Wüthrich, an 84-year-old, Swiss, male scientist, who won the Nobel Prize in 2002 claims that "as a male scientist" he has "a feeling of discrimination." He said this during the 72nd Lindau Nobel Laureate Meeting on a panel that had four old, male
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Our SCING method for gene regulatory network (GRN) modeling for scRNAseq and spatial transcriptomics is formally published. Congratulations to @littman_russell, Michael Cheng, Ning Wang, and @ChaoPeng19. Hope this is useful for your research!
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A third of people are Blood Group A. #SARSCoV2 preferentially infects these cells "providing a direct link between ABO blood group expression and [Covid] infection" https://t.co/Ya7bCrTsVb
@ASH_hematology
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Congrats to all our lab graduates: Dr. Jessica Ding @jaliyahding, Dr. Gaoyan Li, MS Lorin Kirmizi, undergrads Kavya Immadisetty, Ashwathi Nair, Ormina Naveed, Darren Wijaya, Carissa Zhu! It’s a privilege to work with all of you. We are proud of you and wishing you all the best!
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All is welcome to join Jessica’s PhD defense on June 14 at 11am in Boyer 159 to celebrate her journey and learn about her multiomics tools and application studies linking metabolic modulation to Alzheimer’s disease!
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Please join Gaoyan’s PhD defense today (Monday, June 12) at 1:30pm in BSRB Room154 to help us celebrate her achievements and hear about her single cell studies of the hypothalamus and white adipose tissue dynamics which influences a broad range of health conditions.
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Please join me at the Multiomics in Precision Medicine Conference at UPENN! Seating is limited. Use the code TAKE25 to receive a discount. Hope to see you there! Register here https://t.co/yLE2NmkAH6
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Read our latest #research on finding new ways to 🥷 ⛔️#inflammation in #atherosclerosis using #drugrepurposing #systemsimmunology #CyTOF published on @NatureCVR
https://t.co/M6jUMcqL42
@nyugrossman @NYULHCVRC @nyulangone
@GiannarelliL @NIH @ncats_nih_gov 🧵👇
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Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @nature
https://t.co/eIAn8MW6jN
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Truly appreciate the opportunity to work with Dr. Elaine Hsiao @pipethero and Greg Lum on this exciting translational multiomics study of ketogenic diet for pediatric epilepsy!
Very excited to advance our mouse work closer to humans in this study by Greg Lum, Daniel Ha, @YangLabUCLA + co showing that the keto diet for pediatric epilepsy alters the human microbiome in ways that confer seizure resistance when transferred to mice
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Very nice overview of >75 single-cell and spatial multimodal assays, including key applications, and perspectives on where this growing field is headed @NatureRevGenet
nature.com
Nature Reviews Genetics - In this Review, the authors discuss the latest advances in profiling multiple molecular modalities from single cells, including genomic, transcriptomic, epigenomic and...
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