Richard Burman
@RichBur
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Very happy to announce that this preprint is now published in @NeuroCellPress! 👇 .
Thrilled to announce the release of our new preprint. Here we show how fast synaptic inhibition adapts to the level of cortical activity and demonstrate why this could be an important feature of how cortical networks process information.
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Awesome to see this finally out! Congratulations @joshsselfe and @JosephRaimondo!.
Ever wanted to explore the driving forces underlying inhibitory neuronal signalling? We did! So, for my MSc in @JosephRaimondo lab, we developed the all-optical approach ORCHID - all-Optical Reporting of CHloride Ion Driving force. Now out in @NatureComms
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Please check out this exciting new work from the Akerman Lab spearheaded by the exceptionally talented @gsgothard !.
🚨new preprint alert!🚨 very excited to share the story of my PhD work :) including: development of excitatory-inhibitory circuits, lineage labelling, in vivo patching and re-thinking blanket inhibition. See below for a quick summary! [1/17].
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RT @alex_shapsoncoe: Our human connectome project is now published; Thanks to all contibutors, esp @michalj, D.Ber….
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Congratulations to @JosephRaimondo and his incredible team @UCT_NI for pioneering this exciting new frontier for studying neuronal ion dynamics. Happy to have played a small part in this adventure. @PharmOxford Please do check out their awesome preprint 👇🏻.
We are excited to present ORCHID, a new tool for all-Optical Reporting of Chloride Ion Driving force. In the brain, inhibition is mediated by Cl- permeable receptors. ORCHID can therefore be used to quantify the driving force across inhibitory receptors.
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Please do check out our latest preprint which looks how we can study the mechanisms underlying benzodiazepine resistance in children with prolonged seizures 👇🏻 @NDCNOxford @KispiZuerich @KingsCollegeNHS.
Seizures that won't stop - status epilepticus - are a medical emergency. We have some good treatments available, but for some patients these don't work. Here's Tommaso Fedele and @RichBur trying to figure out why some treatments fail for some patients.
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Curious to know about more about meningiomas that venture extracranially? Check out our recent paper spearheaded by @vratko and @sanj_jeyaretna. @UniofOxford @NDCNOxford @OxNeuro.
A small subset of meningiomas metastasise extracranially. The outcomes for these patients are poor and there are no effective management options at present. We present a case series and systematic review of the literature to describe their features.
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Another elegant piece of work from @hannah showing how diurnal fluctuations in synaptic inhibition affect plasticity mechanisms. Check out the preprint now on bioRxiv 👇.
Following up on our discovery that cortical intracellular chloride changes with wakefulness, we now look into how this dynamic affects synaptic plasticity mechanism. Metaplasticity of cortical glutamatergic LTP by diurnal intracellular chloride dynamics
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Here we extend the brilliant work of @M__Mahn and @OferYizhar to show how their stGtACR2 provides an efficient optical tool for studying chloride dynamics across brain preparations and neuronal cell types.
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📢Interested in a new approach to measuring intraneuronal chloride dynamics? Check out our new preprint which demonstrates a new optogenetic strategy that offers many advantages over the traditional agonist-dependent approaches. 👇
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A shout out to @BeckyJordan321 whose excellent protocol was an enormous help in establishing recordings in awake animals.
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Thanks are also given to members of the Akerman Lab @gsgothard @mattiavellian @alfonsahannah @AtreyiChak for their support over the years as well as to Troy Margrie and Mateo Velez-Fort @SWC_Neuro for teaching me how to patch in vivo.
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Many thanks for the support from @LeverhulmeTrust @MRF_Africa @ERC_Research @wellcometrust @OxfordMedSci.
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Delighted to be able to continue to collaborate with @JosephRaimondo @UCT_NI @UCTHealthSci on this project.
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This work was the main focus of my DPhil @NDCNOxford and @PharmOxford @UniofOxford @OxNeuro @BalliolOxford.
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By establishing in vivo perforated patch-clamp recordings and combining the results with computational modelling, we hope to bring a new perspective on how fast GABA-A receptor-mediated synaptic inhibition operates in the cortex.
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Thrilled to announce the release of our new preprint. Here we show how fast synaptic inhibition adapts to the level of cortical activity and demonstrate why this could be an important feature of how cortical networks process information.
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