Hannah Alfonsa
@alfonsahannah
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Neuroscientist - Department of Pharmacology - Oxford University - chloride, cortical inhibition, sleep, plasticity
ÜT: -6.249113,106.948289
Joined September 2009
"Sleep-wake related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses" is now out at @CurrentBiology (1/5 )
cell.com
Alfonsa et al. show that sleep-wake history can account for variations in chloride-dependent EGABAA, which bidirectionally regulate glutamatergic LTP by modulating membrane potential dynamics....
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We conclude that chloride dynamics provide a functional link between changes in a neuron’s physiology that are associated with sleep-wake history and the mechanisms responsible for the induction of glutamatergic synaptic plasticity. (5/5).
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This increased depolarization results in increased LTP. Pharmacological manipulation associated with reduced chloride decreases membrane depolarization and LTP level. (4/5).
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Wakefulness drives increases in pyramidal neuron's intracellular, which lead to increased residual membrane depolarization between action potentials. (3/5).
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Wake and sleep affect brain's plasticity, but how neuronal changes associated with sleep/wake history affect plasticity mechanism is unclear. Here we show that sleep-wake history changes in neuronal chloride affect membrane potential dynamic and LTP. (2/5).
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RT @VVyazovskiy: Sleep-wake-related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses: Current Biolo….
cell.com
Alfonsa et al. show that sleep-wake history can account for variations in chloride-dependent EGABAA, which bidirectionally regulate glutamatergic LTP by modulating membrane potential dynamics....
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We conclude that chloride dynamics provide a functional link between changes in a neuron’s physiology that are associated with sleep-wake history and the mechanisms responsible for the induction of glutamatergic synaptic plasticity.
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This increased depolarization results in increased LTP. Pharmacological manipulation associated with reduced chloride decreases membrane depolarization and LTP level.
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Wakefulness drives increases in pyramidal neuron's intracellular chloride which lead to increased residual membrane depolarization between action potentials.
nature.com
Nature Neuroscience - Alfonsa et al. show that wakefulness causes shifts in cortical EGABAA, weakening synaptic inhibition and resulting in markers of local sleep pressure, and identify Cl−...
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Wake and sleep affect brain's plasticity, but how neuronal changes associated with sleep/wake history affect plasticity mechanism is unclear. Here we show that sleep-wake history changes in neuronal chloride affect membrane potential dynamic and LTP.
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"Sleep-wake related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses" is now out at @CurrentBiology .
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Working situation today! Only for a quick revision of a manuscript then will go back to full time baby cuddling 🥰
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RT @joshsselfe: Ever wanted to explore the driving forces underlying inhibitory neuronal signalling? We did! So, for my MSc in @JosephRaimo….
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RT @gsgothard: 🚨new preprint alert!🚨 very excited to share the story of my PhD work :) including: development of excitatory-inhibitory circ….
biorxiv.org
The degree to which cortical neurons share inhibitory synaptic input determines their co-activity within a network. However, the principles by which inhibition is shared between neurons are not...
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RT @LBKrone: Somonotate – a new sleep scoring algorithm by twitterless Paul Brodersen tested on @VVyazovskiy lab datasets. Advantages:.(1)….
journals.plos.org
Author summary Typically, the three different vigilance states–awake, REM sleep, and non-REM sleep–exhibit distinct features that are readily recognised in electrophysiological recordings. However,...
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RT @VVyazovskiy: Would be great to try/validate this on other data sets. Please help to share and let us know whether and how this worked f….
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RT @VVyazovskiy: Sleep and circadian rhythmicity as entangled processes serving homeostasis | Nature Reviews Neuroscience .
nature.com
Nature Reviews Neuroscience - A prevailing notion in sleep research is that sleep homeostasis and circadian rhythmicity involve independent processes. In this Review, Franken and Dijk discuss...
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RT @mitzideluca: #OxAutNeuro23 kicks off with interesting talks on the Neuroscience of sleep from: Dr Hannah Alfonsa, Dr Julie Seibt, Dr Fr….
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Gramicidin patch after months break is just like riding a bike except that during the break some random people come and mess with your bike in multiple different places, in multiple different ways.
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