Pumiglia_Lab
@PumigliaLab
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A small lab run by a rapidly aging skeptic, doing their best to investigate molecular mechanisms of vascular endothelial growth control and morphogenesis.
Albany Medical College
Joined April 2021
She’s finally here! Meet our new postdoc @BelangerKasey! She joined us from Jen Sullivan’s lab @MCG_AUG. Kasey will be working with us and @PumigliaLab on a collaboration identifying neurovascular interactions of AD risk genes. #EndAlz @AlbanyMedDNET
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Grant awarded! So excited to work on this U01 on impact of #Alzheimers risk genes on neurovascular interactions with Sally Temple @NeuralStemCells @karchlab Oscar Harari @WUSTLmed @MartinUCSF and @PumigliaLab @AlbanyMed. Thank you @Alzheimers_NIH! #EndAlz
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The endothelium puts a brake to cytokine signaling to prevent endotheliopathy and multiorgan dysfunction. Want to learn more? Nina’s paper is out as an in-press preview @JCI_Insight! Thank you to all the amazing collaborators at @AlbanyMedMCP! https://t.co/yEvBtGIxkG 👇📜
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This always feels good...it seemed to be safely below payline but nearly 5 months since council. Thought NIH was changing their mind. They did quite a hack job on the budget considering it was modular - hopefully it went to fund somebody else!
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It’s time to change this slide! @FDA approval today of #sotorasib. Congrats @JonathanOstrem & Ulf Peters on launching the successful attack with tethering from @realJimWells and scientists at Wellspring! Many steps-great to see the summit reached!! @UCSFCancer @HHMINEWS
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Returned to @umichmedicine to check in with my oldest significant experiment, started in Ann Arbor about 26 years ago. I am really proud of the result.
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"grad student" is easier to say than "scientist/lab technician/data analyst/grant- and manuscript-writer/copy editor/project manager/software engineer/graphic designer/teacher/exam-grader/amateur mouse rancher and veterinarian" but somehow feels a lot less accurate
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Amy Kimble and summer student Jordan Silva led an effort to isolate endothelial nuclei from archived frozen brain tissue to allow us to begin to interrogate RNA splicing in the #BBB
A Method for Rapid Flow-cytometric Isolation of Endothelial Nuclei and RNA from Archived Frozen Brain Tissue https://t.co/PaIWxmx1Up
#bioRxiv
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Respect to researchers that use 3D electron microscopy. We took our first dip into this amazing technology and were humbled by the work involved. But the results were amazing! See how pericytes of brain capillaries dig their "claws" into endothelial cells. https://t.co/VHz3iH2Zsm
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No, it’s not a gummy bear come-to-life. This creepy-crawly creature is actually a human #fibroblast cell. A recent #NIDCR study found fibroblasts migrate using a ‘front wheel drive’ mode. Learn how the results could shed light on thwarting #cancer spread: https://t.co/Zxae8Ejafj
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This is not right. @NIHDirector @NCIDirector , @theNCI these are exactly the type of scientists we should be supporting now. Women, especially young mothers, are dropping out of science at alarming rates. I am getting desperate messages from women all over the world. We must help
My ESI status extension for the covid shut down was declined because I was already on my extension for maternity... I have conflicted feelings, but overall, it does not feel fair, does it? @NIHFunding @NIHgrants @NIH
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Meanwhile in the home-lab, the latest batch of Chevre from our "herd" is draining!
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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism From labs of Douglas A. Marchuk & Mark L. Kahn. https://t.co/9sxCOqrHDX
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Big research news today! @AngiomaAlliance
https://t.co/JXEK4UVvY2
nih.gov
NIH-funded study suggests an anticancer drug could prevent bleeding into the brain.
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We are hiring! #Postdoc position available for a collaborative project with @PumigliaLab. Identifying functional impact of #Vascular risk genes for #AlzheimersDisease please RT! @CapDistPostdocs @AlbanyMedDNET @CapSciNY @OSSDtweets #ENDALZ #ExpBio #WiN
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