ICYMI: How does traffic-related air pollution increase the risk of Alzheimer’s disease?. Ameer Y. Taha & team @ucdavis provide new evidence for impaired lipid-resolution pathways underlying Alzheimer’s disease dementia. Traffic-related air pollution also depleted proresolving

ICYMI: Mapping the quiet development of a “silent killer.”. @NeehaZaidi @wonjinho1 @DrLizJaffee & team @hopkinskimmel present in-depth spatial characterization of early precancer lesions in pancreatic cancer (PDAC), noting the organization of lymphoid cell aggregates into

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RT @DBT_inStem: #NewPublication: A new clue in the HCM puzzle! Dr. Dhandapany Perundarai (@Dhan_inStem) and team from BRIC-inStem report a….

Sex-dependent and muscle-specific progression of the MYBPC1 E248K Myotrem myopathy in response to aging

Myotrem is a recently described disease characterized by MYBPC1-associated myopathy. Aikaterini Kontrogianni-Konstantopoulos & team @UMmedschool now find sex-dependent and muscle-specific progression of the MYBPC1 E248K myopathy mouse model in response to aging.

The paradigm for pulmonary fibrosis now includes aberrant wound healing and dysfunctional AT2 cells. Michael F. Beers & team @PennMedicine explore the role of AMP-kinase in the metabolic dysfunction of AT2 cells using mouse and iPSC models of lung fibrosis.

RT @Savai_Lab: 🚨Check out our latest @JCI_insight paper about the use of precision cut lung slices mimicking human lung tumors and immune r….

Does a common missense polymorphism reduce mortality risk in carriers? . Daniel R. Calabrese & team @UCSF analyzed 1,036 patients hospitalized with SARS-CoV-2 infection from a COVID-19 immunophenotyping cohort and found. 👇.

RT @musclecellnews: 💓 Dr. @Pratuljain10 and researchers at @DBT_inStem identified a pathogenic missense variant in tubulin tyrosine ligase….

While BCG immunization was originally developed against M. tuberculosis, it is also known to mitigate other types of infections. @arifmrahman & team @NIH now reveal BCG vaccination promotes efferocytosis and other pro-inflammatory innate immune responses, contributing to the

RT @JABLab3: Congrats @omar_ohhh @morgan_d_payne @Ghandi_Hassan_ and JAB lab on our @JCI_insight paper now in press! @WashUMedPCCM @WashUMe….

RT @mannuabhimanyu: Happy to share this interesting study which is now in press. We found specific Non-tuberculous mycobacterial susceptibi….

Mapping the quiet development of a “silent killer.”. @NeehaZaidi @wonjinho1 @DrLizJaffee & team @hopkinskimmel present in-depth spatial characterization of early precancer lesions in pancreatic cancer (PDAC), noting the organization of lymphoid cell aggregates into tertiary

ICYMI: The images alone will melt your heart—. This issue’s cover image features work by @Dhan_inStem, @Pratuljain10, @Harshilchittora & team @DBT_inStem on a genetic variant of tubulin tyrosine ligase that perturbs microtubule tyrosination in hypertrophic cardiomyopathy:

How does traffic-related air pollution increase the risk of Alzheimer’s disease?. Ameer Y. Taha & team @ucdavis provide new evidence for impaired lipid-resolution pathways underlying Alzheimer’s disease dementia. Traffic-related air pollution also depleted proresolving lipids in

ICYMI: Temporal lobe epilepsy affects ~50 million people globally. @Gary86 @futureneuro_ie @UCD_Conway & team link altered RNA methylation to changes in protein expression, neuronal structure, and seizure susceptibility across models.

In diabetic retinopathy, microvascular damage and inflammation disrupt the blood-retina barrier, but the role of microglia was unclear. Thomas Langmann & team @UniCologne now show suppression of microglia-driven inflammation with minocycline preserves vascular integrity and

Tubulin tyrosine ligase variant perturbs microtubule tyrosination, causing hypertrophy in patient-specific and CRISPR gene-edited iPSC-cardiomyocytes

RT @AJMarianMD: Kindly see the below article that points to the significance of DNA damage in the pathogenesis of arrhythmogenic cardiomyop….

Behind-the-scenes: Dhandapany Perundurai @Dhan_inStem, first author Pratul Jain @Pratuljain10 and co-author Harshil Chittora @Harshilchittora discussing data at the lab!