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🥼 Investigators demonstrate the feasibility of using predicted structural models for optimizing lead compounds, and HEAL-116 provides a promising avenue for the clinical validation of 3βHSD1 inhibitors in prostate cancer therapy. @PNASNews |

📖 The authors summarize the latest drug treatment strategies and clinical concerns in the management of advanced prostate cancer in Japan, based on the Japanese Clinical Practice Guidelines for Prostate Cancer published in 2023. 🔗

💊 Researchers at @DanaFarber uncovered a common MUC1-C-dependent pathway in treatment-resistant CRPC/NEPC progression and identified MUC1-C as a target for their treatment with a M1C antibody-drug conjugate. @JCI_insight |

📈 Scientists showed that dysregulated ubiquitination and turnover by the cullin 3 ZBTB2 E3 ligase complex induce the upregulation of the short isoform of NSD3, which confers PARPi resistance in prostate cancer cells and #mCRPC samples. @MolecularCell |

🧬 Researchers establish FOXA1 as a multifaceted oncogene, with distinct mutational classes divergently evolving to drive prostate tumorigenesis or therapy-resistant progression. 👉 @ScienceMagazine |

🔬 Pharmacological targeting of interleukin-1, JAK–STAT and NF-κB inhibits Pten-induced cell plasticity and reprogramming in a cellular autonomous manner, opening new opportunities for the treatment of prostate cancer. @NatureCancer |

📸 Researchers support the feasibility of using clinical metabolic imaging techniques as adjunctive tools for improving cribriform prostate cancer detection in clinical practice. @PNASNews |

📊 In this study, researchers evaluate the diagnostic utility of GATA3 and CD138 as basal compartment markers in differentiating benign prostatic hyperplasia from prostate cancer. 👉

🖥️ Check out PruEV-AI, a system that provides a robust, non-invasive, and clinically relevant diagnostic approach for accurately identifying prostate cancer, thereby supporting improved screening protocols and more effective therapeutic strategies. 👓

🌡️ Dr. Holger Einspieler and researchers at @MedUni_Wien investigated the effect of hormone therapy on arterial inflammation in prostate cancer patients using [18F]FDG-PET. 🔓

🦴 To understand the role of P2X4R in prostate cancer (PCa) biology, particularly in PCa bone metastasis, P2X4R was knocked out in human PCa cell line PC3 cells using the CRISPR/Cas9 system. 👉

💊 Investigators found that oral medication of D-mannose effectively enhances the radiosensitivity of PSMA-positive murine RM1-hPSMA prostate cancer cells to TRT by suppressing glucose metabolism. @DDTReMedia |

📊 Researchers evaluated the additive ability of 68Ga-RM26 PET/CT as a tracer to predict the prognosis of patients with #mCRPC following therapy. 🔗

🔬 Researchers with Dr. Charlotte Zammit at @UCBerkeley leveraged a cysteine-reactive covalent ligand library in a cellular screen to identify the degraders of androgen receptor and AR-V7 in #androgen-independent prostate cancer cells. @J_A_C_S |

💧 The authors conducted a comprehensive search to screen clinical studies on the application of liquid biopsy for promoter methylation in prostate cancer diagnosis. 🔗

🔎 Investigators explored the prognostic value and potential functions of POLR2H in prostate cancer. Prognosis-related genes for prostate cancer were screened through high-throughput functional screening using #CRISPR. 🔗

🔎 Dr. Charlotte Zammit and scientists at @UCBerkeley leveraged a cysteine-reactive covalent ligand library in a cellular screen to identify the degraders of AR and AR-V7 in androgen-independent prostate cancer cells. @J_A_C_S |

📍 Scientists designed a competitive, modular fluorescent probe targeting the oncogenic EGFR kinase and was utilized for probe-based cytometry to subtype urine samples from prostate cancer patients. @JMolBiol |

🧪 Researchers developed a compound, which contains an N-(4(benzyloxy)phenyl)piperidine-1-sulfonamide scaffold through structural optimization and comprehensive screening against T878A-mutated androgen receptor. 👉