Pouria Dasmeh
@PouriaDasmeh
Followers
123
Following
404
Media
19
Statuses
283
Scientist and Group Leader @ Institute for Human Genetics, UKGM medical center, Marburg University, Germany | Computational and Evolutionary Medicine
Marburg, Germany
Joined October 2017
BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
469
12K
29K
Nice and fundamental work from Hochberg lab.
New paper from the lab from @SriramGarg. We introduce a general substitution matrix for structural phylogenetics. I think this is a big deal, so read on below if you think deep history is important.
0
0
2
We are inviting motivated researchers to join us at the Center for Human Genetics, Philipps-Universität Marburg, for Marie Skłodowska-Curie Postdoctoral Fellowship applications. Join us to work on exciting and fundamental problems in the beautiful city of Marburg!
0
2
4
This was a fascinating collaboration from DAY 1 with the great @tokuriki_lab. We studied and modeled the evolution of antibiotic resistance for over 100 generations. Our work contributes to mechanisms that explain the maintenance of phenotypic variation in the population.
I am very excited to share that our paper led by @erdogananisan, @PouriaDasmeh, @AdrianSerohijos is out @natcomms. It touches key dynamics to understand protein evolution"Neutral Drift" and "Phenotypic Variation" during enzyme/protein evolution. https://t.co/EOJTGv8MNc
0
1
4
This study of aortic stenosis (AS) identified 17 genetic risk loci, most of which were independent of coronary artery disease. Mendelian randomization & genetic correlation analyses revealed that phosphate may be an AS-specific risk factor. https://t.co/eW68HTuTPu
0
5
18
Great opportunity to work with my colleague Johan Åqvist at Uppsala University, using simulation to explore enzyme evolution and adaptation to extreme environments. For more details and an application list, see: https://t.co/n0kPJrIamH
uu.varbi.com
Are you interested in working with computer simulations of enzymes, with the support of competent and friendly colleagues in an international environment? Are you looking for an employer that invests
0
6
13
3: This portal, and others in progress, were beautifully created by the talented ZuKIT start-up team in Marburg ( https://t.co/VX7GNSN5yk). Their work is fantastic, offering a wide range of services in scientific/technical data web-hosting, visualization, and management.
0
0
2
2: Additionally, we launched the Polygenic Evolution Portal ( https://t.co/Xb2qW0C8aV) as a resource for exploring these relationships and generating new hypotheses in the field of human polygenic trait evolution.
1
0
3
1: Excited to share our latest work on the links between evolutionary rate, expression level, and genetic association with polygenic traits! We analyzed 4,576 traits to reveal how natural selection shapes these traits.
academic.oup.com
Abstract. Understanding the expression level and evolutionary rate of associated genes with human polygenic diseases provides crucial insights into their d
1
2
7
Another great work from Picotti lab...
Our paper describing a method to screen for conformation-specific protein-protein interactions is out @MolSystBiol. Read it here: https://t.co/YPPjA8w6BA The approach can also be used to map interaction sites. @IMSB_ETH @ETH @ETH_en
#proteomics #massspectrometry #interactomes
0
0
1
Excited and proud to share our #SingleCell dissection of #ALS and #FTLD out in #Cell this week, across 620,000 cells, 44 cell types, 73 donors, and two brain regions. Although ALS affects #movement vs. FTLD #cognition, the two are nearly identical in the cell types, genes, and
Excited to share our #SingleCell dissection of #MotorCortex in #ALS and #FTLD
https://t.co/JXUlAynClO
#BetzCells #VENs #C9orf72 #TDP43 #POU3F1 #ADRD #NeuroDegen #MCx #Alzheimer with #SebastianPineda #VeroniqueBelzil #MyriamHeiman #HyeseungLee @B_Fitzwalter @Mohammadi_PhD @MTPA_US
18
101
486
Our exciting collaboration with the great @tokuriki_lab on the biophysical basis for the malleability of trait correlation in single proteins (YFP and VIM2 metallo-β-lactamase) and on short evolutionary time scales. https://t.co/dS5XFugAvS
nature.com
Nature Communications - Trait correlations impact evolvability as selection on one trait can influence others. Here, the authors examine trait correlation in two proteins, a fluorescent protein...
1
12
21
Please RT: Exciting PhD-position and opportunity at my department @Biology_LU @lunduniversity in the lab of my colleague @AnjaFelmy on phenotypic plasticity and life-history evolution in guppies (Poecilia reticulata): https://t.co/iLhfkLbjvT
lu.varbi.com
Work duties The main duties of doctoral students are to devote themselves to their research studies which includes participating in research projects and third cycle courses. The work duties can also
0
39
46
Happy to share the recent work from our lab on the single-cell preferential expression of genes associated with esophageal malformations in mouse and human embryos. A mix of gene prioritization and developmental biology. https://t.co/hEDcVHIHCe
1
2
6
30 (!!) PhD student positions in Germany, in Berlin, and in the Cologne area. The plant science, research institutes, and research groups are top-notch. Apply! #sciencejobs #PhDposition #phdchat #phdlife
0
104
135
I played this interesting 7min video on the exciting story of AlphaFold in our course on disease variants. I can't express how well-received this was and students got excited to learn more about AlphaFold and protein folding problem. https://t.co/N9I3RaPc7A via @YouTube
1
0
4
Fully funded PhD position in statistical genetics at the Center for Human Genetics of Marburg University.
0
2
5
I really enjoyed this informative video by @zachbbionerd about the history of the Modern Synthesis, its relationship to evolutionary theory at large, what "gene centrism" is (and is not!) and claims that evolutionary biology is a field in crisis: https://t.co/3K2o7q1ZWf
2
11
50
A list of papers that were rejected before going viral ( = winning a Nobel Prize). It just shows how #science works sometimes. ▫️ 1. Richard Ernst, Chemistry (1991), for NMR spectroscopy The paper that described our achievements was rejected twice by the Journal of Chemical
13
186
468
This is such an amazing work and an incredible resource in cellular biology and medicine. A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain https://t.co/XbdKi4Ieud
0
0
2