Captain Aureispira - a bacterial pirate ship🦜🏴‍☠️🪝- boarded @ScienceMagazine. Check out the manuscript here: and have a look on our extended thread below ⬇️We provide new insights on bacterial predation from molecules ⚛️to ocean samples 🌊

RT @ETH_DBIOL: In a collaboration between the @PilhoferLab and the Albers Lab from the University of Freiburg, the researchers show that h….

Bye bye X/Twitter!.Please come visit us on Bluesky @pilhoferlab.bsky.social for future lab news, including a new paper on an Archaeal Type 6 Secretion System!.

RT @ETH_en: Researchers at ETH Zurich have analysed down to the smallest detail the unusual arsenal of weapons that a predatory marine bact….

The peer-reviewed version of the manuscript can be found here: 🙏 We thank the reviewers for their constructive feedback!.

Fly-fishing for flagella. Check out the lovely perspective by Andrew Lovering and @SimonCaulton 🙏🙏 about our findings on bacterial predation via ixotrophy.

Read the preprint here: to see how we used multidisciplinary approaches like #genetics 🧬, #cryoET ❄️🔬, single-particle #cryoEM, #lightmicroscopy 💡, and functional assays to unravel the secrets of this fascinating antibiotic-producing bacterium. 💊 🧵2/2.

Exciting news!🚀 We have a new follow-up on the cytoplasmic Contractile Injection System from #Streptomyces!💉@casub1, in a wonderful collaboration with @JWSallmenII & @SusanSchlimpert, unveils the critical role of CisA in Streptomyces CIS functionality. ☠️🧵 1/2

An accompanying paper from the Matos lab in collaboration 👯‍♀️👯 with us and the @pedrobeltrao lab and Aebersold lab at @Dev_Cell unveils coordinated waves 🌊🌊🌊 of protein expression and phosphorylation in yeast gametogenesis.

What are the functions of these filaments? Structural characterization and functional assays suggest that Acs1 filaments facilitates the recovery of chronologically aged spores 😴and, more generally, the cell cycle re-entry of starved cells. 🥳🧵(5/5)

Using #FilamentID, we found that the conserved aldehyde dehydrogenase 4 (Ald4) forms filaments in the mitochondria, whereas acetyl-CoA synthetase 1 (Acs1) polymerizes into nuclear and cytoplasmic filaments 🔍 🧵(4/5)

To find out what they are, we combined cryoET with “targeted” single particle cryoEM (we call it #FilamentID) to image partially lysed and spread cells or organelles and identified two different metabolic enzyme filaments. 🤯 🧵(3/5)

We saw that meiotic budding yeast cells are full of different filaments. 🧐(some of you might have also seen them in your yeast tomograms) and these filaments seemed to be specific to meiosis. 🧵(2/5)

To #TeamTomo ❄️🔬: Do you also sometimes see strange filaments in your #cryoET data and don’t know what they are? 🤔 Try #FilamentID! 🪄🤓 Check out our new paper at @CellCellPress by @HugenerJannik and @xujw_thu together with the Matos lab 🧵(1/5)

Free DPANNs are motile, but ectosymbiotic cells are linked with the host via an elaborate attachment organelle, making them the potentially first microorganisms using a straw 🥤 Also have a look at the beautifully complementing story from @DebnathGhosal:

#cryoET as discovery tool ❄️🔬: DPANN archaea are enigmatic, hard to cultivate, and rely on an ectosymbiotic lifestyle. Check out our new paper @ISMEJournal from Vasil Gaisin in collaboration with @Archaellum where we describe two DPANN lifecycle stages:

Have you ever had nightmares of killer archaea? 🔪☠️😱 stop dreaming! Have a look at our latest preprint on how Halogeometricum borinquense uses it type 6 secretion system to kill Haloferax volcanii:

RT @PilhoferLab: It's out! It's out! 📢The bacterial Tc Toxins are out😱☠️ (and our paper 📜😉)! But how did these huge complexes get out? Whe….

RT @NatureMicrobiol: See also the associated paper:. Yersinia entomophaga Tc toxin is released by T10SS-dependent lysis of specialized cell….

Congrats to @miki_hannah and to all collaboration partners.