Pavan Bhargava
@PavanBhargavaMD
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Neuroimmunologist with interests in metabolism, brain-gut microbiome communication, extracellular vesicles and meningeal inflammation.
Baltimore, MD
Joined September 2017
Our latest preprint showing alterations in the proteome of white matter EVs from MS patients compared to controls.
biorxiv.org
Extracellular vesicles (EVs) are increasingly recognized as mediators of central nervous system (CNS) function and pathologies, including multiple sclerosis (MS). While plasma-derived EVs have been...
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RT @Clodida: 1/ I am thrilled to share our latest paper: A single-cell compendium of human cerebrospinal fluid identifies disease-associate….
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RT @MorePerfectUS: A bill to break up UnitedHealth, CVS, Cigna and more has been introduced by a bipartisan group of U.S. senators and repr….
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RT @mcuban: Sometimes it feels really good to get it right @costplusdrugs. Sent: Thursday, November 21, 2024 .Subject: Sincere thank you fr….
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RT @DKrementsov: 1. Excited to have our study out in final form in @JCI_insight ! We used the Collaborative Cross (CC), a genetically diver….
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1. I'm thrilled to share our latest findings in @elife. Using spatial transcriptomics, our study has identified a gradient of immune genes and inflammatory markers extending from the meninges to the brain parenchyma in MS. Thanks to @PavanBhargavaMD
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RT @SaumitraSsingh: 1. I'm thrilled to share our latest findings in @elife. Using spatial transcriptomics, our study has identified a gradi….
elifesciences.org
Leptomeningeal inflammation in a mouse model of multiple sclerosis triggers deeply penetrating gene changes in underlying brain tissue, described using spatial transcriptomics.
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RT @DKrementsov: 1. A cool new preprint from @PavanBhargavaMD 's group that helps to resolve some of the controversy around opposing roles….
biorxiv.org
In multiple sclerosis (MS) the circulating metabolome is dysregulated, with indole lactate (ILA) being one of the most significantly reduced metabolites. We demonstrate that oral supplementation of...
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RT @PavanBhargavaMD: We demonstrate that the alterations in the MS circulating metabolome can have important functional consequences. We id….
biorxiv.org
In multiple sclerosis (MS) the circulating metabolome is dysregulated, with indole lactate (ILA) being one of the most significantly reduced metabolites. We demonstrate that oral supplementation of...
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With @mdkornberg @SaumitraSsingh @Calabre04804429 @Ashu_Mangalam and several other collaborators not on X.
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We demonstrate that the alterations in the MS circulating metabolome can have important functional consequences. We identify a potential mechanism to correct this imbalance to promote repair while also suppressing inflamamtion.
biorxiv.org
In multiple sclerosis (MS) the circulating metabolome is dysregulated, with indole lactate (ILA) being one of the most significantly reduced metabolites. We demonstrate that oral supplementation of...
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RT @biorxiv_neursci: Restoring the Multiple Sclerosis Associated Imbalance of Gut Indole Metabolites Promotes Remyelination and Suppresses….
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RT @IJMSCtweets: "•Increased circulating primary #bile acids are associated with slower brain and retinal #atrophy.•TUDCA supplementation i….
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Out today in @MedCellPress. We show that circulating bile acid levels in MS predict brain atrophy. Also, in a phase 2a trial we demonstrate that TUDCA supplementation is safe in people with progressive MS and impacts the gut microbiome and immunophenotype.
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RT @tweetsatakash: Lipids play a key role in neuroinflammation & injury in #MultipleSclerosis. Structural lipids predict NfL levels, indica….
jnnp.bmj.com
Background Lipids are of particular interest for the study of neuroinjury and neuroinflammation as structural lipids are major components of myelin, and a variety of lipid species modulate inflamma...
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The most ridiculous thing I read today.
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RT @IJMSCtweets: "[W]e demonstrate significant circulating metabolome alterations in [pts with RR #MultipleSclerosis] as result of #ocreliz….
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Our latest manuscript examining changes in the circulating metabolome with Ocrelizumab treatment. Led by Fatemeh Siavoshi - Annals of Clinical and Translational Neurology
onlinelibrary.wiley.com
Background Circulating metabolite levels are altered in multiple sclerosis (MS) and are associated with MS severity. However, how metabolic profiles shift following highly efficacious therapies,...
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RT @JuliePaikMD: Thrilled to announce that @PavanBhargavaMD and I have been awarded a UM1 @NIAMSFunding to establish the “Hopkins Autoimmun….
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RT @PavanBhargavaMD: Taking to twitter to see if someone can help. I’m traveling to London on Friday and currently hitting dead ends trying….
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