Patrick Heizer
@PatrickHeizer
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Biomedical engineer, permaculture farmer, Camus scholar, Maryland supremacy, husband, and father.
Frederick, MD
Joined December 2009
There are fundamental reasons that lab-grown meat shouldn't be the foundation of our meat production system. My latest: https://t.co/sNh9YUG9Kg
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Reminder that universal gift cards already exist. Stop giving corporations free 0% interest loans in exchange for a piece of plastic garbage.
Just went to buy two $50 gift cards. They ring me up and say the total is $111.90. How is this legal?
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The pro-worker, anti-union platform: -universal healthcare -strict anti-monopolu enforcement -mandatory employee seats on boards -stricter prosecution of wage theft -cap executive's total comp to a ratio of median comp -tax benefits for worker co-ops -universal basic income
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There are now much better ways to protect workers (e.g. universal healthcare, mandatory worker seats on all boards, etc.) Time to evolve past this archaic arrangement that fossilizes organizations.
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The Left hates police unions. The Right hates teacher unions. Everyone hates the longshoremen union. When will we realize that it's unions that are the problem.
just pretty remarkable to see a transit union leader explicitly his goal is to increase jobs for his members, not to improve transit service
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It's really very simple game theory. Why would some wealthy unilaterally disarm and let the others continue to run amok while the current misguided policies continue? The only stable equilibria are following current tax law or changing it.
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And Citizens United adds an extra layer. Liberal wealthy donating their money to the Treasury reduces the need to rectify our fiscal & debt situation, while giving conservative wealthy more relative money to influence every single election & own every media organization.
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The Right often criticized student loan forgiveness because if we forgive the debts w/o fixing the underlying system, they'd just start accumulating again, especially since schools would know a bailout exists. Now you know why wealthy liberals don't donate to the Treasury.
The “tax me more” crowd is pretty insufferable. The federal government could tax every American billionaire into homelessness, and it wouldn’t even pay off 1/5 of the national debt. But if you really want to pay more, you can stop virtue signaling and do it. There’s a website:
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Apparently my newsletter is ranked #75 in "Rising in Philosophy," which I'm both incredibly humbled by but also in disbelief at.
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Y'all probably thought I was playing!
I could be the richest person in the world and I'd still wrap my presents in the local newspaper, no ribbons, no gift tag, the name just written on an extra piece of tape.
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I just used AI for the first time. I asked Gemini to make a birthday invitation for my toddler that combined unicorns and Pixar's Cars. The result was genuinely impressive!
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Medicare was built on a promise: seniors will have access to timely care when they need it most. That promise is in jeopardy due to outdated payment policies. See how we can fix it together and safeguard our future.
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Bought myself some books for Christmas. Which would you read first?
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@TheStalwart To answer the "how are amino acids made? question from @tracyalloway: Almost all industrial-scale amino acids come from microbial fermentation, i.e. microorganisms genetically-modified to overproduce certain amino acids, which you can then extract and purify from the 'soup'
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Finally, just to answer the "what is a peptide?" question from @TheStalwart: it's a chain of ~50 or less amino acids. Even if you limit it to just the 20 natural amino acids, that's 20^50 total peptides! Total protein possibility space is even larger! https://t.co/kBdFIjFT7X
Finally, my fourth journal club later today, will discuss possibility spaces, evolutionary landscapes, and the oncospace for human cancers. A though provoking paper from @ricard_sole
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Re: long-term Short-term outcomes can just be proxy for longer-term risks, i.e. not "real" results For example, muscle/injury recovery from BPC-157 might just be angiogenesis (new blood vessels) that make you feel better, but expose you to other risks https://t.co/7EykG06esV
Grateful to all the people injecting angiogenesis promoting peptides systemically. I’m sure there won’t be consequences to that at all.
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Re: low probability Consider the vaccination-induced myocarditis, which occurred at a peak rate of ~100 per 1,000,000 in a specific age cohort of one sex. There is just no way that household experimentation and forum posting properly elucidates that.
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The primary safety concern with Chinese peptides isn't toxicity or contamination (peptide synthesis isn't hard (please still get verification testing), but low-probability and/or long-term side effects that only proper clinical and epidemiological research can uncover.
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Imagine that the current standard-of-care for some disease has a 20% success rate. It is obviously harder to discover a therapeutic with a >20% success rate, simply because there are less possible things that meet that new threshold.
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If you rank order all possible ideas from the easiest to hardest, I genuinely don't know how anyone could claim that there wasn't and isn't a bias to discovering the former over the latter.
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If ideas aren't getting harder to find, then why were some previously-discovered ideas discovered first? Did humanity just randomly discover iron smelting before uranium fission? Coal before shale? Insulin before GLP-1?
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I have never understood people who make this claim; it is obvious that successful ideas are getting harder to find. The number of ideas that improve productivity 10x is smaller than the ones that improve productivity 5x, etc.
Thought provoking article. TLDR: we are generating novel ideas at the same pace, but the downstream barriers to getting them translated are getting worse. In particular, more innovative players are increasingly disadvantaged in markets. I’m still digesting this, especially
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