Exciting News: Our Paper is Published! 🎉. I’m thrilled to share that our paper, RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy, is now officially published in EMBO Reports!

Interestingly, when we eliminate Caspase-8-mediated apoptosis, the mice are fully protected from the pathology. We also discovered that the microbiota plays a key role in driving intestinal elongation, while TNF is responsible for the villus atrophy. Check it out!.

We show that when T cells lack the TNF-signaling component RIPK1, mice develop small intestinal inflammation and intestinal elongation. This pathology mirrors what has been observed in humans with RIPK1 deficiency, making it crucial to understand how this condition develops.

A special shoutout to Jelle for leading much of the research and to Wolf for performing the final experiments and addressing the rebuttal. I'm incredibly proud to be the last author on this paper and to see how the story came together.

Full paper here: RIPK1 ablation in T cells results in spontaneous enteropathy and TNF-driven villus atrophy | EMBO reports.

RT @MarioRuizPrez1: 🚨Excited to share our new review in @FrontImmunol on #TCellDevelopment in the #thymus across space and time. From multi….

RT @MarioRuizPrez1: 🎉 Exciting news! I am delighted to share that the main core of my PhD is finally available online: "TL1A and IL-18 syne….

Special thanks to @MarioRuizPrez1 for his great effort in getting this out. @c_maueroeder for his knowledge and passion for neutrophils @SpringerNature @VIBFlowCoreGT @InflamResCen.

Our paper on thymic granulopoiesis is out!! The thymus can produce neutrophils during acute thymus atrophy when Notch is downregulated. We show that TL1A and IL-18 can synergise to induce extramedullary thymic granulopoiesis in a GM-CSF-dependent manner

RT @LabWaggoner: TL1A and IL-18 synergism induce acute thymus atrophy while  promoting extramedullary thymic granulopoiesis in a NOTCH and….

Special thanks to Jelle and Wolf, who does not have twitter, but made this story possible! @SpringerNature @cddpress @InflamResCen.

Super excited to share our new paper! We show that T cells require the protein RIPK1 to survive after exiting the thymus to avoid TNF-mediated apoptosis. This was a great effort, Thanks to everybody involved! 🥳 #cdd

RT @MarioRuizPrez1: 🎉 Excited to share the team's latest publication in @SpringerNature @CDDpress! Thrilled to have been part of this big e….

Super proud of this paper! We show that the thymus is more than a T cell producer, and during type 1 immunity can produce peripheral homing ILC1s!

Super proud supervisor! To see my first PhD student, Jelle, defending his PhD in such an excellent fashion. Well done, Jelle!! 🥳👏👌

RT @GeorgGasteiger: Endspurt! Last chance to submit your abstract to the Tissue Homeostasis&Immunity #NK and #ILC meeting, few last spots a….

RT @JanssensLab: (1/12) 🚨 For all DC lovers out there, 📢our paper on homeostatic dendritic cell maturation is finally out! @SciImmunology.h….

RT @lai9uan: We are thrilled to share our review article: "Origin and Heterogeneity of Tissue Myeloid Cells" with @FGinhoux @ImmanuelKwok #….

RT @MartinGuilliams: 🚨To all macrophage & dendritic cell fans. Last time we organised a VIB Myeloid cell meeting we were completely sold-ou….

RT @VIBpostdocs: This weeks spotlight is now online, find out about some more committee members @geeky_cris and @P_Tougaard 🤓🧑‍🔬 https://t….