Pascal Geldsetzer
@PGeldsetzer1
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Assistant Professor of Medicine and, by courtesy, of Epidemiology and Population Health, Stanford University; CZ Biohub – San Francisco investigator
Joined June 2020
Nice piece by @richardsima in the Washington Post this morning on our recent study ( video: showing large protective effect for dementia from shingles vax: @StanfordDeptMed @StanfordMed @StanfordHP @czbiohub.
washingtonpost.com
The findings could have implications for managing the large and growing burden of dementia.
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What’s next? A randomized clinical trial! This relies on philanthropy because we want to trial a version of the old shingles vaccine which is no longer being manufactured. Reach out if you want to help fund! @Stanford @StanfordDeptMed @StanfordMed @StanfordHP @czbiohub.
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What if we already have a vaccine for dementia? Great explainer of my group’s new Nature paper ( on shingles vax by @ChrisWorsham @AnupamBJena: and summary by @EricTopol: Video here:
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RT @StanfordHP: Remarkable new study published in @Nature by SHP affiliated faculty @PGeldsetzer1 strengthens the link between shingles vac….
med.stanford.edu
A new analysis of a vaccination program in Wales found that the shingles vaccine appeared to lower new dementia diagnoses by 20% — more than any other known intervention.
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RT @czbiohub: Check out a video of @PGeldsetzer1 explaining his intriguing new study in @Nature. 📽️🔗
czbiohub.org
CZ Biohub San Francisco Investigator analyzes health record data to find evidence that a shingles vaccine can lower the chances of developing dementia
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Huge thanks to my postdocs @meyting3, @mx_sci & Seunghun Chung; PhD student Felix Michalik; co-author @simonhhess; and peer reviewer @AnupamBJena.#dementia #Alzheimers #shingles #epitwitter #econtwitter #neurotwitter #NeuroTwitterNetwork #Neuroscience.
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What’s next? We want to run a randomized clinical trial. This relies on philanthropy because we want to trial a version of the old shingles vaccine (that’s what we’ve all the evidence for!), which is no longer being manufactured. Reach out if you want to help fund!.
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We see the same protective effect in dataset after dataset from different countries that rolled out the shingles vaccine in similar ways --> this can’t just be a chance finding!
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Other studies have all compared people who go get vaccinated to those who don’t --> these are folk with very different health behaviors. So, what you get then is much more likely to be biased.
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You take 1,000 people born one week and 1,000 born just a week later --> no reason to think that they should differ in their health behaviors 🏃♀️🧑🍳. So, we have beauuutiful comparison groups. This is an opportunity to get at cause and effect!
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What’s so special about our study? In Wales, if your 80th birthday was just b4 the start date of the shingles vax program, you were ineligible. If it was just after, you could get the shot. Just a week’s difference in age means your chances of getting vaxxed jump from 0 to 50%!
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Shingles vax appears to prevent dementia! Our Nature paper is first of many from my group to show this. We use a really neat natural experiment to provide causal (not just correlational!) evidence. Paper: video (👏 @DrMayaAdam):
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RT @StanfordKingCtr: 🚨Postdoc Opportunity! .Accepting applications for Postdoc Fellowships in #health and global development. Deadline: D….
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RT @czbiohub: New work in @Nature by @stanford #CZBiohubSF Investigator @pgeldsetzer1 and colleagues provides causal evidence that UK's amb….
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Would love feedback on our newest quasi-experiment published this week in @Nature (. Summary below by amazing first author @jmlemp. @StanfordDeptMed @StanfordMed @stanford_pcph @StanfordEpiNews @StanfordHP @StanPopHealth @StanfordDBDS @czbiohub #epitwitter.
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RT @NathanLo3579: Interested in a post-doc/scientist role @Stanford in infectious diseases, epidemiology, modeling, and public health? Come….
careersearch.stanford.edu
Department of Medicine) at Stanford University is seeking an LSRP2 (Life Science Research Professional 2) to join our research laboratory. Dr. Nathan....
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