PDBrown
@PDBrownOnc
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Husband, dad, grandfather, lifelong learner, amateur brewer, outdoor enthusiast, Professor Radiation Oncology #Brainmet #radiosurgery #radonc
Rochester, MN
Joined May 2012
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Cognitive recovery after radiation brain mets meta-analysis · 1/3 cognitive recovery @6mo after initial decline · Recovery more likely if SRS or HA-WBRT compared to WBRT https://t.co/S7aeKaiHAA
academic.oup.com
AbstractBackground. Although there are data describing the onset of neurocognitive toxicity following radiation for patients with brain metastases, less is
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Randomized Trial Spine SBRT Target Tumor only vs. Tumor+ Elective Coverage ↑↑tumor control with Elective Target coverage https://t.co/MD9phgu9jw
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Congrats Dr. Camilo Jimenez LITESPARK-015 team Most driven by dysreg HIF-2α pathway 83% on trial had HTN Belzutifan (Welireg) Response 49% VHL RCC, 83% panc neuroendo, 63% CNS hemangioblastoma
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Belzutifan HIF-2α inhib Phase 2 Advanced Pheochromocytoma/Paraganglioma · Median PFS 22 mos · 32% ↓↓ HTN · AE 22% Gr3 anemia https://t.co/7jseiVL3i7
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Randomized Trial Fractionated Radiosurgery vs SRS Surgical Cavity Brain Mets · Will Analyze results soon · I worry there may be no signif diff (have not seen the data), which will upset some · Regardless Excited to see results!
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Thank you @brynmcmyers @ShaunaRadOnc @CShahMD perfect PRO study HS mean age 21 Hurley Stage I Abscess Stage II Recurrent Abscess, sinus tracts, scar Stage III diffuse, interconnected sinus tracts abscess
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RT for HidradenitisSuppurativa · HS chronic autoinflam boils,abscesses,fistulas sweat glands · Adalimumab 59% response vs.28% placebo · 7.5Gy/5 QD IMRT Historic 40% CR 40% PR https://t.co/ojjjTNnTNM
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🚨Our new paper is out today in Nature! We show that SARS-CoV-2 mRNA vaccines can sensitize tumors to immune checkpoint blockade (ICI) — revealing that clinically available RNA vaccines may act as potent immune modulators.
nature.com
Nature - mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
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Thanks @subatomicdoc Dr. Chalmers thought provoking RT (i.e. 20-30Gy) Ankylosing Spondylitis ↑leukemia 0.17% 40-50’s UCSF, U Chicago, etc. injected unknowing patients w/ radioactive material to study metab & nuclear safety! Rationalization is a powerful way to convince yourself
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Radiation Medicine Review · 🚨Adult Language Warning “H” word used😉 · Atomic bomb survivors low dose fallout ↓CA ↑OS compared to rest Japan · Biggest critics LDRT often CANCER translational, radiobio experts w/ limited experience LDRT benign diseases https://t.co/0nxee8tNs5
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Visiting Professor why? Is it worth giving up 2 days of vacation/family time?
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Knee Arthrofibrosis Case report · Lysis of adhesions · Post-Op 8 Gy · All 3 patients improved ROM https://t.co/wyZVMhq12A
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Kudos @MyrsiniIoakeim & colleagues amazing such a large prospective trial chordoma w/decades of F/U
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Prospective Trial BOS Chordoma 24 Year Followup! Patterns of Failure: No Sig benefit dose escalation? https://t.co/RJQdl0h8nr
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Re-RT for Recurrent GBM is radiosurgery effective (instead of 10 fractions)? -YES according to this trial -All patients received Bev -In my clinic most recurrent tumors > 3.5 cm https://t.co/OBUUElpa9b
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