Mark V. Mishra Profile
Mark V. Mishra

@MarkMishraMD

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Radiation Oncologist, Assoc. Director of Marlene and Stewart Greenebaum Comprehensive Cancer Center (Network), Vice Chair @UMarylandRadOnc Clinical Research

Baltimore, MD
Joined June 2019
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@MarkMishraMD
Mark V. Mishra
26 days
RT @UMarylandRadOnc: Congrats to this year’s #radonc medical resident grads! Colleagues celebrated during graduation dinner, where certific….
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@MarkMishraMD
Mark V. Mishra
27 days
RT @UMarylandRadOnc: Congratulations to faculty members Dr. Mark Mishra @MarkMishraMD on receiving ARRO Educator of the Year & Dr. Junliang….
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@MarkMishraMD
Mark V. Mishra
1 month
RT @ZeidanMd: 🔥NSABP- B51 is out!.Practice changing trial supporting RT de-escalation in cN1, ypN0 breast cancer. 👉longer follow up desired….
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25 MR-guided FUS + TMZ OS ↑ (36.4 vs 19.1 mo) & ↑ PFS in HGG vs matched controls in Phase 1/2 trial. BB barrier opened safely in 100% of cases; cfDNA tracked disease. Promising noninvasive platform for targeted delivery.@UMGCCC @UMDNsgyChair .
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25: In pts with 5–20 brain mets, Phase 3 trial shows SRS/SRT leads to significantly better QoL vs HA-WBRT (↓ symptoms & interference, p<0.001), with no OS difference (8.3 vs 8.5 mo). SRS/SRT should be new SoC in this setting. #radonc.🔗
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25 Final CATNON trial results confirm: adjuvant TMZ (not concurrent) improves OS in IDH-mut anaplastic glioma (12.5 yrs vs 1.7 yrs in IDHwt). No added benefit from concurrent TMZ. RT→adjTMZ remains standard for IDHmt, 1p/19q-intact disease #btsm.🔗
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25: In Phase III KEYNOTE-630, adjuvant pembrolizumab after surgery+RT in high-risk LA cSCC did not significantly improve RFS vs placebo (HR 0.76, p=0.072). More TRAEs with pembro (64% vs 41%). Trial stopped early for futility. #radonc.🔗
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25: In LA gallbladder CA, adding CRT to neoadjuvant chemo doubled OS (21.8 vs 10.1 mo, p=0.006) & ↑ R0 resection rates (52% vs 30%) vs chemo alone in Phase III trial (N=124). First RCT evidence favoring NACRT in this tough-to-treat disease #radonc.🔗
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25: In COG ACNS1123, children with NGGCT treated with proton vs. photon WVRT had significantly better long-term IQ outcomes. First prospective data showing protons preserve cognition in pediatric brain RT. Photon RT linked to IQ decline over time. 🔗
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25 Phase III SWOG/@NRGonc S1914 trial shows adding atezolizumab to SBRT in early-stage NSCLC did not improve OS or PFS. More grade ≥3 AEs & local failures seen with IO+SBRT vs SBRT . First major phase III to test this combo—results are cautionary.🔗
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25 PROs from OUTBACK (N=919) show adding adjuvant chemo to CRT in LACC ↑ toxicity (e.g neuropathy) without OS gain. Long-term issues—sexual dysfunction, fatigue, pain—persisted through year 3. Survivorship care in #radonc must address unmet needs. 🔗
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@MarkMishraMD
Mark V. Mishra
2 months
#ASCO25: CAN-2409, a gene therapy that induces immunogenic tumor cell death, cut recurrence/death risk by 30% (HR 0.7, p=0.0155) in int/high-risk localized prostate cancer when added to RT±ADT. 80% path CR vs 63.6% with SoC. Low added toxicity. #radonc.🔗
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@MarkMishraMD
Mark V. Mishra
3 months
RT @DoctorQMd: Putting the brightest inquisitive minds together to find cures for cancer .@MayoClinicNeuro .@MayoClinic .@MayoCancerCare .@….
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@MarkMishraMD
Mark V. Mishra
7 months
RT @SimonLo21054188: Consensus Radiation Treatment Planning Guidelines Utilizing (68)Ga-DOTATATE PET/CT for Resected Meningiomas - Internat….
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@MarkMishraMD
Mark V. Mishra
9 months
RT @ASTRO_org: In this new #RedJournal article from @MarkMishraMD @hrcherng et al, read about an exploratory analysis of the conditional ne….
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@MarkMishraMD
Mark V. Mishra
11 months
RT @StasLazarev: ⚡️Today FDA approved Vorasidenib for IDH-mutant low grade gliomas. When patients ask you about this drug, make sure to inf….
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@MarkMishraMD
Mark V. Mishra
1 year
RT @UMarylandRadOnc: Congratulations to Dr. Hua-Ren (Ryan) Cherng @hrcherng on winning the department Medical Resident Article of the Year….
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@MarkMishraMD
Mark V. Mishra
1 year
RT @UMarylandRadOnc: Congratulations to this year’s residency program graduates, Drs. Jie Ding, Rebecca Krc @KrcRebecca & Bansi Savla @Savl….
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@MarkMishraMD
Mark V. Mishra
1 year
RT @S_W_R_O: 💔 We are heartbroken to announce that a member of our #RadOnc community (@UMarylandRadOnc Muhammad Hamza, PGY3) was recently s….
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@MarkMishraMD
Mark V. Mishra
1 year
RT @UMGCCC: UMGCCC was recognized by @NRGonc, a major research group within the NCI's National Clinical Trials Network, as a top "main memb….
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