Nikhil Panicker
@NikhilPanicker2
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Assistant Staff/Professor investigating mechanisms of inflammation & neurodegeneration in Parkinson's, Alzheimer's & related disorders @ClevelandClinic, @CCLRI
Cleveland, OH
Joined April 2019
Greetings! My newly-established lab at the Cleveland Clinic is looking to hire 1-2 motivated postdocs to explore neuroinflammatory signaling mechanisms that contribute to pathology in #parkinsons #synucleinopathies and #alzheimers diseases . (1/3).
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RT @PhDWilliamsJess: Out today in @CellReports we show that the novel #astrocyte transcription factor BATF2 tempers type II interferon resp….
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Thanks to @CDMRP for supporting this project !.
Microglia and NLRP3 Inflammasome Contribution to Nonmotor Deficits in Parkinson's Disease.Nikhil Panicker, Ph.D., Cleveland Clinic Foundation @ClevelandClinic.#ParkinsonsResearch.
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RT @PhDWilliamsJess: Another #Neuroimmunology Holiday Gift Exchange is in the books!! 🎁 I’m so looking forward to what the next year holds….
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Many thanks to the @APDAParkinsons community for funding so many exciting #Parkinsons projects! Looking forward to seeing exciting science ensue!.
Our grant recipients are working tirelessly to understand the complexities of #Parkinsons disease. Thank you for your kind contributions to APDA that help make their work possible! To learn more about their research, visit:
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RT @kastanenka: Next week, Dr. Kastanenka is back on the road! We greatly appreciate the opportunity afforded by the Cleveland Clinic to sh….
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RT @TrendsNeuro: 'Inflammasome assembly in neurodegenerative diseases'. @TrendsNeuro Review article by Jagjit Singh, Maria Habean & Nikhil….
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Our review article on Inflammasome assembly in neurodegenerative diseases is now online at @TrendsNeuro. The first ever manuscript to come out of the Panicker Lab @CCLRI › :D.
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RT @DivitaMathur: Grateful to @RCSA1,the Frederick Gardner Cottrell Foundation and other sponsors for an amazing weekend and then funding s….
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RT @DivitaMathur: Our group is looking for a #postdoc with background in in vitro #cellbiology and #molecularbiology, and interested in de….
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RT @PhDWilliamsJess: I’m so grateful for these amazing colleagues ❄️ Another successful #neuroimmunology gift exchange in the books ☃️ With….
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❤️this paper from @EnnerfeltHannah, @LukensJohnR and co. from @BIG_Center_UVA ! Microglial SYK ablation leads to⬆️ amyloid plaque burden & memory impairment in 5X FAD mice. SYK marshals neuroprotective responses by facilitating plaque clearance! .
cell.com
SYK is a central intracellular regulator of microglial activation and phagocytosis that is deployed to limit Aβ pathology and demyelinating disease.
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RT @CCLRI: Dr. Nikhil Panicker's lab in the Department of Neurosciences: Link to job opening: .
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Our #R00 grant (finally) came in! The first grant (sorta) for the Panicker Lab!. #Postdoc positions still open for investigating #Inflammasome activation in #Parkinsons #DementiaWithLewyBodies @CCLRI Dept. of Neurosciences. Please DM or email me if you have any queries :)
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RT @PhDWilliamsJess: 🍻 So fun to treat the #neuroimmunology trainees from the Bergmann, @DavalosLab, @LouveauAntoine, @DeSilvaTara, @Nikhil….
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Out today in print, "Taking the parkin brakes off of neuronal NLRP3" from @LukensJohnR & @kzengeler , previewing our @NeuroCellPress paper,. out in the same issue :D.
cell.com
Inflammasomes are multimeric signaling platforms traditionally shown to be assembled in immune cells. Here, Panicker et al. show that inactivation of the E3 ligase parkin from dopamine neurons...
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Specifically, we seek to explore how #inflammasome activation contributes to pathology in #neurodegenerative diseases. Experience in #parkinsons in vivo models would be a major asset! Please DM or email me if you have any questions! (3/3).
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Mentorship of the candidate(s) wrt promoting training and collaborations with labs at the Cleveland Clinic @CCLRI and beyond, applying for fellowships, grantsmanship, reviewing articles, and facilitating the transition to your long term goals will be a priority! (2/3).
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We will be pursuing further adventures on inflammasomes and their roles in Dementia with Lewy Bodies, PD and AD at the Dept. of Neurosciences @CCLRI, DM me if you'd like to collaborate/join the team! . (3/3). P.S: Link allows free access to the article for the next 50 days :).
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