Tao Ni
@NiLab_HKUMed
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Assistant Professor (2022 - ...) University of HongKong Postdoctoral Research Scientist (2016 - 2022) University of Oxford
Oxford, UK
Joined December 2019
A novel cryo-EM affinity-grid approach utilizing monodispersed single-particle streptavidin on a lipid monolayer is introduced to improve particle absorption, thereby addressing challenges like preferential angular distribution https://t.co/PlJo2KjTFG
@eBIC_Diamond @OxfordStrubi
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Very excited to share our first work after establishing my lab in Hong Kong University @HKUniversity Tremendously grateful to the development of PACEtomo to make the data collection possible within a reasonable period of time. @RadoDanev . https://t.co/vfTSsi7YXG
nature.com
Nature - A study details the molecular architecture of the double-membrane-spanning pore formed by the proteins nsp3 and nsp4 in double-membrane vesicles of SARS-CoV-2.
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So happy to finally announce the TomoTwin clustering workflow release! We wanted to optimize the clustering interface to make it truly interactive and easy for users to explore their tomograms using TomoTwin’s information rich embeddings. 🧵👇
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View from Magdalen Tower on #MayMorning. Around 16,000 people attended this year’s event! 📷 | @DinahGLRoseKC
#MayDay
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Seventy years on from the discovery of the structure of DNA, controversy still surrounds two central points: how much credit Rosalind Franklin deserved, and the degree to which she was denied it
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Very happy to share our recent work on protein biogenesis at the ER membrane. We analyzed 150,000 ribosomes from 1000+ tomograms of ER-derived vesicles to visualize ribosome intermediates and their downstream translocon machinery. 1/ #TeamTomo #CryoEM
https://t.co/MXeQ598RvZ
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Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
nature.com
Nature Structural & Molecular Biology - LRRK2 is one of the most commonly mutated genes in familial Parkinson’s disease. Here, the authors report a cryo-EM structure of the catalytic half...
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Interested in using atomic force microscopy to visualize biological membrane architecture, protein organization, interactions and dynamics? We have a postdoc position open for application now. https://t.co/8rE2UoQYAY
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A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0
elifesciences.org
New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.
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📃 Exciting new preprint! Ultrastructural characterization of a viral RNA and G-protein containing, membranous organelle formed in respiratory syncytial virus (#RSV) infected cells. Read here 👉 https://t.co/jrwH6N85Tg
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Isonet paper is published online now on nature communications! Congrats to Yuntao @yuntaoinnit and Heng!
Isotropic reconstruction for electron tomography with deep learning https://t.co/IMx5Ysrow8
#MachineLearning #NatureJournal #AI
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Structural basis of actin filament assembly and aging
nature.com
Nature - Cryo-electron microscopy structures of skeletal F-actin show solvent-driven rearrangements governing actin filament assembly and aging with potential application in design of drugs and...
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Today, we’re introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish. https://t.co/OAsiOVFStI
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Cryo‐EM structures of perforin‐2 in isolation and assembled on a membrane suggest a mechanism for pore formation
embopress.org
image image Perforin‐2 is an innate immune effector protein that forms pores in the membranes of phagocytosed bacteria. Here, cryo‐EM imaging of pre‐pore and pore complexes of perforin‐2 in isolation...
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#CryoSPARC is made with ❤️ by our team @structurabio. We wish everyone happy #cryoEM processing and speedy results! 9/9
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BREAKING NEWS: The 2022 #NobelPrize in Physiology or Medicine has been awarded to Svante Pääbo “for his discoveries concerning the genomes of extinct hominins and human evolution.”
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Nature research paper: Visualizing translation dynamics at atomic detail inside a bacterial cell
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Very impressed again today
Thrilled to share our structure of mammalian sperm microtubule doublet at ~3.5Å identified almost all MIPs (>40), out of which >15 are novel a new era for #maleinfertility
https://t.co/CckV6OunAL
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