Murray Clarke Lab
@MurrayClarkeLab
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Accidental group leader in Cambridge. Inflammation, Immunology, IL-1, Vascular Biology, Cellular Senescence.
Cambridge, England
Joined March 2019
Very excited to have helped out on this excellent study where IL-1:IL-1R2 controls Tcell contraction.! 👍. Now I'm contracting back to the safety of innate immunity. .
Online now: A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction
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RT @yorgomodis: Looking for an Assistant Teaching Professor and Course Director of the MPhil in Translational Medical Research at Cambridge….
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Last few days to apply for this. 👍.
Job Alert! Come join us in the stunning new HLRI building to study Vascular Inflammation, Macrophages and IL-1 on a 3yr BHF funded grant. @MedCambridge @TheBHF @Cambridge_Uni #Immunology #Macrophage #vascular . Please RT. Research Associate (i.e. PostDoc).
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RT @MedCambridge: 🚨Job alert🚨 . Research Associate (Fixed Term) to join @MurrayClarkeLab in the stunning @HLRI_Cambridge to study vascular….
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Come and work with us in the stunning new HLRI building to study all things vascular inflammation, macrophage, IL-1. 3yr BHF funded PostDoc postion.
Research Associate (Fixed Term) @Cambridge_Uni
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Job Alert! Come join us in the stunning new HLRI building to study Vascular Inflammation, Macrophages and IL-1 on a 3yr BHF funded grant. @MedCambridge @TheBHF @Cambridge_Uni #Immunology #Macrophage #vascular . Please RT. Research Associate (i.e. PostDoc).
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RT @HLRI_Cambridge: Want to come and help us deliver on our mission to improve cardiovascular and lung health worldwide? . @HLRI_Cambridge….
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RT @hfj22: Postdoc in single cell RNA-Sequencing and Functional Genomics in Cardiovascular Biology @Cambridge_Uni
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RT @iamslambert: Interested in a 4-year PhD studying the genetics of BMI and comorbidities? Don't wait, apply for my @AstraZeneca-funded st….
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RT @HLRI_Cambridge: Fabulous work published in @ScienceMagazine by @AndresFloto @flotocambridge and colleagues 👇. @Cambridge_Uni @RoyalPapw….
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Fantastic new work from my office mate and colleagues.!.
Happy to see this work from @JordiLambert and @SebnemOc out today. We identify RUNX1 and TIMP1/CD74/STAT3 as vascular smooth muscle cell regulation through gene regulatory network analysis. @TheBHF @HLRI_Cambridge @Cambridgecardio @MedCambridge
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RT @Cambridgecardio: We are pleased to announce our next speaker in the Cambridge Cardiovascular Seminar series - h….
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New Paper Alert! One of the longest, most traumatic projects ever - like working on a moving target at times. We got there. Thanks to all @katpyrillou, @Meri421_cam.@mallat_lab, @MedCambridge, @HLRI_Cambridge and of course @TheBHF 👍👍.
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RT @Meri421_cam: Very happy to share our article showing that T follicular helper cells protect from atherosclerosis promoting IgM secretio….
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Little News and Views @GroupXuan and I wrote. Still disappointed they didn't let us use the pun-tastic:. You CANT(os) have CHIP(s) with JAK(ets) or your plaques may (fibro)Blast apart - but blocking IL-1b may help.
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Fully recommend Atherosclerosis journal - the editors were excellent throughout and curated the process. i.e. they were not afraid to stand up to over bearing reviewers.
VSMCs are efficient activators of IL-1β that do not use canonical inflammasomes or caspases. Hence, this alternative pathway could be targeted for long-term treatment of CVDs, as it is not central to everyday host defence @MurrayClarkeLab.🔗
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. and it only took 3 reads of the title in PubMed before I clicked, as my first thought was 'who's ripped off our work'. !! 🤦♂️😂.
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Always nice to have an Editorial written about @3M_Alejandra's recent paper. Even more so when's it by Petri Kovanen, who actually knows all about vascular chymase.! . Inhibition of chymase-dependent production of IL-1β by smooth muscle c.
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RT @Akhilesh_Jha: Happy New Year 2024!. and a Happy New Job?!. 🫁 Come work with us at @HLRI_Cambridge on an exciting new @The_MRC funded….
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RT @Cambridgecardio: Proving we can drag ourselves away from our facinating #research and have some festive fun 🎄😋😊
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