Andres Floto
@AndresFloto
Followers
342
Following
58
Media
2
Statuses
89
VPD HLRI, U of Cambridge. Co-Director CCAIM & CID. Combining ML + genetics to understand bacteria-host interaction and create new antibiotics
Joined June 2014
We're seeking 2️⃣ research associates to join Professor @AndresFloto's lab @HLRI_Cambridge. You'll be part of a multidisciplinary team exploring antibiotic uptake, efflux & metabolism across multiple bacterial pathogens. Apply before 27 October: https://t.co/jZWOBXtLfL
1
3
4
Thrilled to share our latest paper now out in @ScienceMagazine 🎉🤩 We investigated a century of plasmid evolution 🧬 and uncovered how they have adapted to the antibiotic era 💊
science.org
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data...
6
31
133
We're delighted that Felicity Crawshay-Williams (a final-year @MedCambridge PhD student) was presented with a PhD Student Award by the Cambridge Society for the Application of Research for her work tackling #AntimicrobialResistance. Read more:
caths.cam.ac.uk
A St Catharine’s student who has been studying how to tackle antimicrobial resistance was one of just 12 PhD researchers recognised by the Cambridge Society for the Application of Research (CSAR)...
0
2
2
Pinte, @VallierLab et al. explore the role of EHF in lung homeostasis & disease by differentiating hiPSCs into lung airway epithelial cells & seeding them in an air–liquid interface culture system that mimics aspects of the respiratory tract environment. https://t.co/x1StDkIhtM
1
1
2
Check out Maciek's tweetorial for our new bacterial protein language model Bacformer, creating a unified representation of bacterial genomes with links to pre-print, code, tutorials and blog post: https://t.co/iNSXMJMSt8
💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve. Preprint 📝: https://t.co/NmxA68rLqC 🧵 1/n
0
5
12
💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve. Preprint 📝: https://t.co/NmxA68rLqC 🧵 1/n
7
89
354
Most importantly, huge shoutout to everyone who made this possible @aaron_weimann, @mariabrbic, @AndresFloto, @abelson_david and others! Thanks to them, the project was first and foremost immense fun! 🧵 15/n
1
1
2
So happy to share my work @jrpenades lab 🤩 We investigated the efficiency of HGT mechanisms in S. aureus🧬, finding that LT is the most efficient one, and that strains defective in immune systems🛡️act as gateways for inter-clonal complex HGT🔀 https://t.co/0eZXldhGWH
biorxiv.org
Horizontal gene transfer plays a key role in bacterial evolution, yet its efficiency under natural conditions, especially between genetically distinct strains, remains unclear. Using Staphylococcus...
1
18
52
Meet @Chaitanya_VS Growing up on a leprosy ward in India, he witnessed the impact of the disease. So he decided to do something about it! His latest research into leprosy has a secured £1.3m boost. Watch his story or https://t.co/93JwJlVRrP read about the funding. @MedCambridge
0
3
7
One week left to join @AndresFloto's team as a Postdoctoral Research Associate to develop new antibiotics against mycobacteria using permeability-enabled fragment-based #DrugDiscovery. This 2-year position is based in @CambridgeBRC. 🧬Apply now: https://t.co/TmcU99z8bC
0
2
3
Hear more from our Professor Eoin McKinney, @AndresFloto & @MihaelaVDS on how we're unleashing the full potential of AI in health and medicine, and how @CC4AIM puts us in the perfect position to be leaders in the field⬇️ https://t.co/YBArmzZzAt
#ShapingAIForEveryone
cam.ac.uk
AI has the potential to transform health and medicine. It won't be straightforward, but if we get it right, the benefits could be enormous. Andres Floto, Mihaela van der Schaar and Eoin McKinney...
0
1
3
Exciting PhD studentship opportunity on understanding chemical permeability to advance antibiotic drug discovery @flotocambridge
https://t.co/yUeUo32Myg. Combines experimental approaches with in silico screening and generative AI.
0
2
3
Let the best teachers guide your next steps on your AI Journey! Our #SummerSchool for AI in Medicine brings you top experts to share insights on AI-driven medicine, LLMs, decision support, & real-world impact! 📅 12-14 Sept 2025 Secure your spot today: https://t.co/7HIRhGF4TN
0
5
15
0
1
3
My first paper as corresponding author is out @PLOSBiology! 🤯 Super proud of my amazing collaborators @cazares_adr (co-corresponding), @cazares_dan, @NobregaFL and everyone else! (not in twitter) And so grateful to the fantastic editors and reviewers! https://t.co/oZJ6l16bif
journals.plos.org
Genomics and experimental characterization of the anti-CRISPR gene family AcrIF7 reveal that is mainly mobilized by temperate phages, and is highly conserved due to slow co-evolution with its target....
8
16
89
We are very excited to announce our latest work on how MRSA conquers antibiotics. We show that high-level resistance to methicillin requires S. aureus to utilise an alternative mode of cell division to ensure its survival! @Sheffield_AFM @Olulana4
https://t.co/y2UcirhNZN…
3
25
73
Very excited to announce the first conference on Advancements of Microbiology, next April in Warsaw We have an exciting line up for the Pathogen Genomics forum including @AndresFloto @Lucy_Weinert @Chris3Ruis Registration and abstract submission https://t.co/GksPRn60YU
advmicro2025.pl
We are excited to embark on a journey of discovery, exploration, and collaboration in the dynamic field of microbiology. Your participation in this first international conference on “Advancements of...
1
4
10
Spacedust: de novo discovery of conserved gene clusters. Combining sensitive Foldseek structure search and conserved neighborhood detection to discover functionally-associated gene clusters in prokaryotic & viral genomes. 🚀 https://t.co/SkFl2Cn8GM 📄 https://t.co/TnS4uAPc3a 1/6🧵
3
58
202
We are jointly investing £15 million with @LifeArc1 in a translational research programme to accelerate the development of new diagnostic tools and therapeutic approaches for CF lung infections, guided by the insights and experiences of people with CF. ➡️ https://t.co/TOz7P3T8yh
0
11
34
Ahead of next week’s High-Level Meeting on AMR, we look at the role of blood cultures in diagnosing infections and contributing to the global effort to contain AMR. https://t.co/0cJYapVPKY
thelancet.com
The second UN High-Level Meeting on Antimicrobial Resistance on Sept 26, 2024 is expected to address the looming threat that antimicrobial resistance poses to global health and food security.1 The...
0
30
86