Roman-Ulrich Müller
@MuellerRom
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scientist and MD, aiming to bring novel strategies to fight kidney disease from basic research to the clinic with a focus on dietary and metabolic interventions
Joined April 2021
1/ 🚨 Big news from our Genes&Kidney Working Group at the @ERAkidney We just released a consensus statement in Nephrology Dialysis Transplantation aiming to bring us closer to precision medicine in CKD. 🧬🩺 🧵 THREAD 👇
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Our experts explain: CKD of unexplained cause: ERA G & K Consensus - Prof. @ecorneclegall , Prof. Halbritter, Prof. @MuellerRom
https://t.co/vxLZsuJuGG They present the CKDx consensus statement of the ERA Genes & Kidney Working Group, published in NDT.
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SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller https://t.co/cuCXRZvUTr
@ecorneclegall @MuellerRom @AKronbichler @sara___helena @gunnar_heine @doc_sae
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Transition of patients with hereditary nephropathies from pediatric to adult care https://t.co/cuDRRIll5u Transition…such an important topic for improving patient care…but still underrepresented in care pathways.
academic.oup.com
ABSTRACT. Adolescents and young adults with chronic kidney disease (CKD), particularly those with genetic kidney diseases, face unique challenges as they t
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Now open access in @NDTsocial CKD of unexplained cause (CKDx): A consensus statement by the Genes &Kidney Working Group of the ERA 🧐Check also our 2 open access editorials on this innovative concept. ▶️ https://t.co/E3AlNE29wO
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Tonight (and later on demand): @MarkusAtHome
#ADPKD @goKDIGO and ERA Genes & Kidney WG Guidelines with @ERAkidney's President @torra_roser and @MuellerRom Hosts: @AKronbichler Dominique Guerrot Academic Partner: @NDTsocial @hjanders_hans
https://t.co/ct55ecz544 via @YouTube
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Always glad to discuss with the MARKUS@HOMe team!
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The @goKDIGO ADPKD Guideline is a milestone for the field. Building upon this work, experts assembled by the @ERAkidney Working Group Genes&Kidney now provide additional practical guidance for polycystic liver disease in #ADPKD. https://t.co/gtYtlm4HQw
academic.oup.com
ABSTRACT. The Kidney Disease Improving Global Outcomes (KDIGO) 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal
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@AKronbichler @MarcusSaemann & I are thrilled to discuss CKD-X in early Autumn with @ecorneclegall @MuellerRom at @MarkusAtHome @NDTsocial platform My personal opinion: A too sophisticated nomenclature may impair its implementation - keep it as simple as necessary @hjanders_hans
CKDx: Simplicity matters, implementation is key https://t.co/x4kbOtWg2g At this stage, it's all about widespread adoption of a simple concept: we do not always know the diagnosis in kidney disease. Reporting diagnostic steps in a simple manner enables us to go the next step.
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CKDx: Simplicity matters, implementation is key https://t.co/x4kbOtWg2g At this stage, it's all about widespread adoption of a simple concept: we do not always know the diagnosis in kidney disease. Reporting diagnostic steps in a simple manner enables us to go the next step.
academic.oup.com
We would like to thank the authors for their interest in the CKDx statement. While we are delighted to see that, in essence, the authors agree with the gen
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Obtaining a thorough family history is so important in kidney disease....but often more difficult than expected in clinical practice... 10 tips on how to take a proper family history in CKD patient care url:
academic.oup.com
ABSTRACT. Patients with chronic kidney disease often present with a family burden of disease. However, efficient collection and documentation of family his
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Happy to share the nice video @UniCologne has produced on our recent publication identifying novel protein biomarkers for #ADPKD. https://t.co/vWyTlywc0t
https://t.co/N9cExnvpr4
@CECAD_ @UKKoeln
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KDIGO ADPKD Guideline: A Milestone in Genetic Kidney Diseases Why is a global guideline for ADPKD so important? Prof. @MuellerRom explains how the new KDIGO guideline marks a crucial step forward in harmonizing care for patients with #ADPKD) worldwide 👇
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Interested in a postdoctoral fellowship on polycystic kidney disease? Linking molecular data with outcome? Please get in touch. https://t.co/JeefJMbx4o
euraxess.ec.europa.eu
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Thank you, Gunnar. Simplicity matters, implementation is key. Looking forward to getting your opinion on our reply (soon to be published).
I am positive that @MuellerRom and @ecorneclegall's CKDx initiative is a necessary step forward! Against this background: Dear @nephrobug @Laurent_Mesnard let's keep our CKD nomenclature manageable for clinical practice 😉🫣 @hjanders_hans @GlassockJ
https://t.co/220jlp25Xe
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📎 Read the full study here: Nature Commun. 16, 6646 (2025) – DOI 10.1038/s41467-025-61887-8
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10/ This work was enabled by all patients participating and central support by the Jörg Bernards-Stiftung and @DFG through the Excellence Initiative (@CECAD). Thank you! @CECAD_ @UniCologne @UKKoeln and Zentrum für Molekulare Medizin Köln
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9/ Next steps: • Develop targeted assays for the 6 proteins • Prospective multicenter validation • Explore integration with other data layers (e.g. metabolomics) and treatment response • Ultimate goal: precision-medicine profiling for ADPKD care
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8/ Why it matters: ✅Blood-based protein markers are inexpensive and accessible ✅ They improve prediction where MRI and genetics may fall short ✅ Pave the way for targeted assays (e.g. ELISA, mass spec) and prospective clinical use
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7/ Notably, the proteome data adds predictive information independent of eGFR at baseline. In ROC analysis for identifying rapid progressors (>3 ml/min/yr) adding the protein to MIC enhanced the AUC
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6/ These models were cross-validated in two large cohorts: an internal cohort (Cologne) and an external cohort using EDTA plasma instead of serum (Groningen).
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