Laurent MESNARD
@Laurent_Mesnard
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Nephrologist, Researcher, Genomic of kidney diseases, allogenomics
Paris
Joined October 2015
CKDx: a necessary step—but can we go further? https://t.co/Cfxuu5BMBP see also the tutorial video attached on the @NDT website #nephrogenomics @com_SFNDT. A dymamic framework for the operational sharing of CKDx data, and better understanding of CKD of uneXplained cause (CKDx)
academic.oup.com
The classification of chronic kidney disease (CKD) without a definitive diagnosis, such as CKD of unknown origin (CKDu), remains a major clinical challenge
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📽️Watch Dr Laurent Mesnard present the NDT publication: CKDx is a good start - But can we go further? https://t.co/VbYmaM4Xz2
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Now online in @NDTsocial How hyperkalemia affects the heart: clinical implications 🧐The ECG of hyperkalemia differs between AKI and CKD through the rate of IC/EC gradient modification. ▶️ https://t.co/JjQtukPoUi
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Systematic Screening of ADTKD-MUC1 27dupC Variant through... : Journal of the American Society of Nephrology
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Listen November 2024 ASN podcast @ASNKidney in which our JASN article on systematic detection of 27DupC MUC1 variant is discussed @JASN #nephrogenomics
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Séquencer un génome en moins de 48 heures !
acteursdesante.fr
Un test génomique qualifié de « clou du congrès » de la Société Française de Médecine Prédictive et Personnalisée (SFMPP) par son président, le Pr Pascal Pujol.
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Core Curriculum by @AW_Aron88 and @ndahl48: Clinical Genetic Testing in Nephrology: Core Curriculum 2024 https://t.co/bMzQ1yJOTc (FREE) @MedStarGUHNeph @MayoClinicNeph
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Aujourd'hui nous avons discuté au congres de la #SFMPP2024 /conférence DÔME de l'errance diagnostique et de la place de la génétique y compris en médecine Interne @Laurent_Mesnard @KevinYauy @Club_immu_inee @contactfai2r @_ERNRITA @AAlliance_SAID @HopitalTenon @FaculteSanteSU
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Study of kidney disease hospitalizations finds that genetic kidney disease leads to higher & more costly admissions than non-genetic chronic kidney disease, highlighting the need for tailored secondary prevention & resource allocation https://t.co/JdcqOCGtaO
@AndrewMallett8 #GIMO
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We're thrilled to announce the publication in Blood of this letter demonstrating the feasibility and impact of rapid genomic screening for managing thrombotic microangiopathies (TMAs). TMAs are a group of severe blood disorders characterized by the formation of small blood clots
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Don‘t miss this! It‘s now clear that a large proportion of CKD cases have a monogenic cause. Understanding the test results is easier than you may think, this Genes&Kidney e-seminar will provide the essentials. Meet the experts.
📢 Join us at the WG e-seminar organised by G&K WG & @ynptweets: *How to read a genetic test result* 📅 October 8, 2024, at 5:00 PM (CEST) 🆕Live e-seminars are real-time translated into 7 languages. Register now 👉 https://t.co/yMdi9vTAPQ
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@JASN_News @nephrobug Great! 👏 An effective method to identify potential #MUC1 patients quickly and easily. This takes us further towards a clinical trial. #ADTKD
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The MUC1 gene is associated with ADTKD, leading to CKD. This study found that SharkVNTyper enables the analysis of highly repeated regions, such as the MUC1 VNTR. https://t.co/IdJ5GnZ3P9
@nephrobug
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This is worth a new thread. Not quite 24 hours. 50 Gb of data with an N50 of 115kb from a single load on a flow cell. This compares with 33.4 Gb in the same time from a standard flow cell with the same library and 2 loads. These beta flow cells need to stop being beta @nanopore
Trying out some more of the @nanopore improved buffer flow cells announced at #NanoporeConf . P1 is a regular flow cell. P2 is an improved buffer. They've just completed first mux scan. P1 lost a lot of pores - P2 did a lot better N50s on these are "tasty"... more as it happens!
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Hair-straightening cosmetics containing glyoxylic acid induce crystalline nephropathy https://t.co/tCHNDLL7t8
@nephrobug @APHP @Inserm
#acutekidneyinjury #AKI
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Huge applause to Veronique Fremeaux-Bacchi for receiving the medal for being an Outstanding Complementologist, from the European Complement Network 🏅🌹👏 It was so emotional to present a laudation to my mentor and friend. @CRCordeliers
#complementbiology
#EMCHD2024
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Check out our last work on rapid genomic for TMA management in less than 3 days in Blood journal! @nanopore @BloodJournal @Sorbonne_Univ_ #SCAI
@TenonUntr #aHUs #CNRMAT @Filiere_MaRIH @APHP
https://t.co/saZoWtrd14
ashpublications.org
In this Letter to Blood, Yousfi and colleagues describe a rapid genomic nanopore sequencing assay for thrombotic microangiopathies that reduces genetic dia
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📢 New research underscores the critical role of pangenomic sequencing in patients with High-Risk APOL1 Genotypes for screening a Mendelian kidney disease. —>It highlights the importance of keeping an open mind. https://t.co/EKqQFUk0pD
#KidneyDisease #APOL1 @Laurent_Mesnard
kireports.org
Among individuals with high-risk APOL1 genotypes, the lifetime risk of developing kidney failure is ∼15%, indicating that other genetic variants or nongenetic modifiers likely contribute substantia...
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Happy about this tripleX: Title page and editorial on our kidney paper in BLOOD (journal) about gasdermin D in renal TMA @CRC_TRR332 #neutrophil biology Free link: https://t.co/zWRYFB5nFw Editorial: https://t.co/Pp8NNfkzvu
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