Emilio Mottillo
@Mottillo_Lab
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Husband, father, Assistant Scientist at Henry Ford Hospital interested in metabolic research. Tweets are my own.
Detroit - Windsor
Joined August 2019
We have the lab up and running! Looking to recruit a post-doc to join us in the “D”. Applicants interested in metabolic disease research with an inkling towards using imaging approaches to study lipid metabolism. DM @Mottillo_Lab Please RT. Thanks!.
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RT @DanielJDrucker: The tragic transition of 🇨🇦 from fighting alongside 🇺🇸 in 2 world wars and in Afghanistan, rescuing American hostages i….
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Finally, LD targeting of PNPLA3 I148M is required to promote steatosis in vivo. Overall, data suggest a critical role for PNPLA3 I148M - LD localization to sequester ABHD5 and promote steatosis.
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Targeting of ABHD5 to LDs is also required to promote the interaction with PNPLA3. So both proteins need to be on LD!.
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Lipid droplet targeting of PNPLA3 I148M is also required to sequester ABHD5 away from ATGL (aka PNPLA2).
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We show that lipid droplet (LD) targeting of PNPLA3 I148M is required for the interaction with lipase co-activator ABHD5 (aka CGI-58).
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Our JBC paper is now online! Here we examine the mechanisms by which a common genetic variant in PNPLA3 (148M) causes fatty liver disease and builds upon our previous work on the interaction of PNPLA3 with ABHD5.
jbc.org
The storage and release of triacylglycerol (TAG) in lipid droplets (LDs) is regulated by dynamic protein interactions. α/β Hydrolase domain-containing protein 5 (ABHD5; also known as CGI-58) is a...
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New study from @Z_GerhartHines lab identifying a novel pathway regulating food intake and energy expenditure .
nature.com
Nature - In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as...
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Had a great time in Munich at the Helmholtz Diabetes conference. It was an honor to be nominated for the HeIDi Young Investigator award and present our work. Wonderful meeting all the new people and connecting again with colleagues!.
helmholtz-munich.de
Helmholtz Munich, is a member of the Helmholtz Association of German Research Centres
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RT @helmholtz_diabc: Let the games begin! 🎉. The 11th Helmholtz Diabetes Conference has officially begun! Stephan Herzig just opened the ev….
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Our paper is now online! Here we investigate the direct effect of lipolysis on AMPK signaling in adipocytes. Using our real-time FRET sensor we show lipolysis genereates long-chain acyl-CoAs that are involved in allosteric activation of AMPK.#lipidtime.
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New work from S. O'Rahilly's group shows GDF15 drives nausea and vomiting duirng pregnancy. Interesting study!
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Happy to share my promotion to Associate Professor of Physiology at Wayne State University @waynestate.
Congrats to Dr. Emilio Mottillo who was recently notified he has been promoted to Associate Professor (Research) FTA in Physiology effective August 2024!
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Great job by graduate student in my lab Andrew Butcko presenting at the @nih_nhlbi T32 Training grant retreat.
Trainees (prior and current) presenting at the 2023 Detroit Cardiovascular Training Program (NIH T32) #NIH #NHLBI retreat at #WSU #timbryson
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RT @cohenlaboratory: Preprint alert! We are happy to introduce Contact-FP, a suite of probes for studying #MembraneContactSite dynamics. Th….
biorxiv.org
Membrane contact sites (MCSs) are sites of close apposition between two organelles used to exchange ions, lipids, and information. Cells respond to changing environmental or developmental conditions...
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Interesting new work showing serotonin as a suppressor of human BAT. The authors propose this may explain weight gain associated with SSRIs. The serotonin transporter sustains human brown adipose tissue thermogenesis | Nature Metabolism
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New works shows that ABHD5 (CGI58) controls placental lipid metabolism indepdent of ATGL (PNPLA2). ABHD5 also interacts with PNPLA9 adding to the list of PNPLA binding partners. JCI Insight - The lipase cofactor CGI58 controls placental lipolysis
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RT @KernLipid: Jennifer Lippincott-Schwartz, PhD @JLS_Lab will be delivering the Closing Kern Lecture at this years conference. She'll be….
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New work showing the Kidney in an axis to mediate the anorexic effects of metformin/GDF15. Renalkines anyone?.
cell.com
Zhang et al. demonstrated that metformin induces kidney GDF15 synthesis to increase plasma GDF15 levels and activate GFRAL in the AP to lower feeding and weight in rats. This study highlighted the...
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Congrats to Cristoph Thiele and his lab. Looking forward to the read!.
Super interesting study which allows quantification of the glycerolipid cycle. .
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RT @HenneLab: Very exciting 2024 @FASEBorg Lipid Droplet Conference in the works, co-organized by @OlzmannLab and us. Stay tuned for more d….
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