Mithu
@MithuBaidya
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GPCR biology, Assistant Professor @ IIT Jammu
Jammu and Kashmir, India
Joined May 2011
In our latest work, we uncover the structural basis of binding and inhibition of non-brain-penetrant CB1R antagonists that holds promise as therapeutic options for obesity while minimizing the risk of on-target psychiatric side effects. https://t.co/X7iVQsHSqZ
nature.com
Nature Communications - Peripherally restricted CB1 inhibitors retain the weight loss benefits of this drug class while sparing the negative psychiatric side effects. The authors here elucidate...
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We look forward to answering your queries.
BSBE Department's Ask-Me-Anything Session to Address PhD Queries To attend, please visit: https://t.co/jvA6qAVuS0 Meeting ID: 961 8369 2567 Passcode: X6D40z
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We are happy to share our latest piece @NatureSMB describing structural insights into an intracellular biased agonist for GPCRs. Congratulations to @neeraz777 PhD trainee and Tarumoy Das, a summer intern in our lab.
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Thank you organizers, for inviting me to the #RYIM #Srinagar . It was a fantastic opportunity to connect with the young minds of the @kashmirUni . Amazing place and amazing people.
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Fantastic news this. Much needed.
Govt. has approved enhancing emoluments for JRF/SRF/RAs engaged in R&D activities whereby they will receive following fellowships/month w.e.f 01/01/2023: JRF - Rs 37,000 SRF - Rs 42,000 RA1 - Rs 58,000 RA2 - Rs 61,000 RA3 - Rs 63,000 @DrJitendraSingh @srivaric @guptaakhilesh63
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Govt. has approved enhancing emoluments for JRF/SRF/RAs engaged in R&D activities whereby they will receive following fellowships/month w.e.f 01/01/2023: JRF - Rs 37,000 SRF - Rs 42,000 RA1 - Rs 58,000 RA2 - Rs 61,000 RA3 - Rs 63,000 @DrJitendraSingh @srivaric @guptaakhilesh63
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Our collaborative story published in Cell describing how preassociation of B-arrestins to membrane is important in GPCR activation. A fantastic multi-lab effort led by @DavideCalebiro Congratulations all !!!
cell.com
Spontaneous preassociation of β-arrestin with the plasma membrane facilitates its interactions with receptors and subsequent activation.
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Fantastic effort led by @DavideCalebiro Happy to be a part of it. Congratulations all!!
Wonderful international collaboration with Jana Selent and @t00mek88 @GRIB_Barcelona, @SteveH025 and @DrJoelleG @uniofnottingham, @arshukla and @MithuBaidya @IITKanpur, Carsten Hoffmann @UKJ_Jena, and our own @Owen_lab_UoB and @MashaUOB @COMPARE_UoBUoN
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Fantastic opportunity this in multiple disciplines. Please look into our website @IITJammu for further details. Please RT.
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We enjoyed a lot two beautiful talks by Dr. Laura Humphrys and @MithuBaidya today. Congratulations to both for their new positions! @MithuBaidya is recruiting new lab members and looking for collaboration partners! Do not hesitate to reach him. @ErnestNetwork @DrGPCR
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Many congratulations to all the lab members, and all the collaborators @THebertMcGill @Laporte001 @JanaSelent Asuka Inoue @TohokuUniPR and all the funding agencies @serbonline @India_Alliance @IITKanpur
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The work demonstrates how a conformational selective intrabody can help re-wire GPCR signaling. The allosteric modulators like this can be used therapeutically to influence GPCR- function for a desirable outcome.
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Congratulations to all including all the lab members and all the collaborators involved.
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A collaborative study involving seven different laboratories across six different countries @IITKanpur @mcgillu @TohokuUniPR @SNUnow @CSIR_CDRI @UMich @TohokuSeika @luker_md @kk_kawakami
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The finding has huge implications for areas like tumor development, survival, angiogenesis, metastasis, and tumor microenvironment.
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The study underpins the transducer coupling bias among this GPCR (CXCR4)-ACR (CXCR7) system, interestingly having a common natural ligand CXCL12. Fantastic effort by the team led by @arshukla
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Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system https://t.co/gFN8WCKFHu Extremely happy to share our new findings on yet another important Arrestin coupled receptor (ACR), CXCR7. Congratulation to all the authors.
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Excited to share our recent work where we describe the function of synthetic nanobodies as allosteric modulators of β-arrestin mediated GPCR trafficking and signalling!! Thanks to @arshukla- for his unwavering guidance and support. https://t.co/X2SGw1VtVS
biorxiv.org
Agonist-induced phosphorylation of G protein-coupled receptors (GPCRs) is a primary determinant of β-arrestin (βarr) recruitment and trafficking. For several GPCRs, such as the vasopressin type II...
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Fantastic team effort by all the colleagues @madhuchatur @hemlata_dwivedi @Ashu_bhu @Shubhip97 @MinakshiBarua @BhanupriyaPani3 @the_rarejm @RamanujBanerje5 @THebertMcGill Jana Selent, Stephane Laporte, Dominic Devost, Yoon Namkung, @t00mek88 led by Fantastic @arshukla
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