Mineto Ota
@MinetoOta
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MD/PhD. Rheumatologist. Postdoc at Stanford @jkpritch and UCSF @marsonlab. Interested in genetics and immunology.
Joined January 2022
It was fun writing this short piece on the omnigenic model. Sharing it here, though it's a painful time as my family, along with millions of others, is at risk in Iran and the region.
New online! Making sense of the polygenicity of complex traits
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I'm delighted to present our nationwide effort to identify genetic determinants of child health and development in Japan. https://t.co/S60LZr71oe
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New approach to discovering the biology of GWAS signals “by combining quantitative estimates of gene-trait relationships from loss-of-function burden tests with gene-regulatory connections inferred from Perturb-seq experiments in relevant cell types.”
Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵
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I am truly grateful to my mentors @jkpritch, @Marsonlab, and co-authors @spence_jeffrey_ , @tkyzeng, Emma, as well as all the wonderful members of the Pritchard and Marson labs for their incredible support!
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Thank you Jonathan for the elegant explanation of our recent work! We dove into how we can model the gene regulatory architecture of complex traits with 1) gene effects from LoF burden tests and 2) Perturb-seq. It’s been an incredibly exciting and thought-provoking journey!
Modern GWAS can identify 1000s of hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm excited to present our new work combining associations + Perturb-seq to build interpretable causal graphs! A🧵
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In a country where women's voices are silenced, a young Iranian woman, Parastoo Ahmadi, held an 'imaginary' concert. Fearless of the punishment that awaits, she sang and inspired the dream of a free Iran. A true symbol of resistance. Full video here: https://t.co/1atMjbXr3Z
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Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led to dynamic mechanisms required to control T cell rest and activation. Published today in @Nature thanks to the work of many! https://t.co/eS0wpVeQQB
nature.com
Nature - Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.
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In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
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For many traits there is a correlation between the number of duplications or loss-of-function (LoF) mutations someone carries, and their phenotype. Curiously, for most traits, these effects are aligned in the SAME direction. Why?
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#ASHG24 folks, I’m giving a talk on Nov 6 on the fundamental differences in gene discovery with common vs. rare genetic variants. Hope to see you there!
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BREAKING NEWS The Norwegian Nobel Committee has decided to award the 2024 #NobelPeacePrize to the Japanese organisation Nihon Hidankyo. This grassroots movement of atomic bomb survivors from Hiroshima and Nagasaki, also known as Hibakusha, is receiving the peace prize for its
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🚨New Preprint Alert: Our work led by @JinghuiLi14637 is up on bioRxiv. We re-analyzed large maps of trans-pQTLs, and found that protein–protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits. A brief thread🧵👇
Protein-protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits https://t.co/Tje3bj8Ddo
#biorxiv_genetic
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The Nagashima lab @MCB_Harvard seeks an ambitious postdoc in immunology, microbiome and diet. Apply here👇 if you want to work on T cell biology in an incredible environment. https://t.co/Djf9C44kEI
@Harvard #immunology #microbiome #postdoc
academicpositions.harvard.edu
The Nagashima lab seeks an ambitious postdoctoral fellow in the areas of immunology, microbiome, and diet.
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HLA is the locus that everyone loves to hate, so it rarely gets invited to the GWAS party... There’s good reason for this. The region has extensive LD, high gene density and high polymorphism. (Thread + preprint link below ⬇️) (1/8)
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Thrilled to share the bulk of my PhD work, now up on bioRxiv! This project brings together aspects of network theory, systems biology, and single cell genomics, towards understanding properties of gene regulatory networks (GRNs). Read on for more —> (1/) https://t.co/RY1syLiS6S
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Delighted to announce that I will be joining the Department of Molecular & Cellular Biology at Harvard University @MCB_Harvard @Harvard as an Assistant Professor this August: https://t.co/gvtvbiSLSS The Nagashima lab is interested in immunology, microbiome, and diet. We attempt
mcb.harvard.edu
Two new faculty, Kazuki Nagashima and Marissa Gredler, will join MCB as Assistant Professors in the upcoming months. Kazuki Nagashima studies interactions between immunology, the microbiome, and...
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Excited to share the last paper from my PhD, advised by @spence_jeffrey_ and @jkpritch! We explore a new way to study selection on complex traits that circumvents some of the most troublesome limitations of GWAS https://t.co/bGFtmwz2ia (1/9)
biorxiv.org
Natural selection on complex traits is difficult to study in part due to the ascertainment inherent to genome-wide association studies (GWAS). The power to detect a trait-associated variant in GWAS...
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We are recruiting postdoctoral fellows! Interested in using quantitative tools to study gene regulation in stem cell-derived developmental models? See below for more info and reach out
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We have multiple postdoc positions available in my group at NYU. Join us if you're interested in complex trait genetics and biology. More information about the lab on our website: https://t.co/oLGhJLK5Oe
https://t.co/GziSix6Zhq
med.nyu.edu
NYU Grossman School of Medicine offers a range of opportunities for postdoctoral fellows to collaborate with our world-class researchers.
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