Mildred Unti
@MildredUnti
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PhD @WeillCornellGS in @JaffreyLab; B.S. in Microbiology, Immunology & Molecular Genetics @UCLA in @Kohn_Lab
Berkeley, CA
Joined September 2019
So excited to announce that my most recent work has been published. If you’re interested in genetically encoding circular mRNA, or packaging circular mRNA into virus-like particles for cell-type specific delivery, this paper is for you!
Online now! Highly efficient cellular expression of circular mRNA enables prolonged protein expression by Mildred J. Unti @MildredUnti, and Samie R. Jaffrey @JaffreyLab at @WeillCornell #resource
https://t.co/a2fuiCqQDM
#chembiol
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Happy to announce that PERT is now published in @NatureComms ! With PERT, we explore replication timing variability (Fig 3-4), chrXi reactivation (Fig 5), and how S-phase fractions struggle to approximate clone fitness (Fig 6). https://t.co/V0WqwX5G6e 1/n
nature.com
Nature Communications - Here the authors develop a probabilistic model for single-cell DNA sequencing of aneuploid tumors that infers clone-specific replication timing and S-phase fractions,...
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The future of genome editing is in vivo! Check out our latest @PNASNews perspective from @doudna_lab. Had a lot of fun discussions with @kevin_wasko and @JRo_Hamilton about the past, present, and future of in vivo delivery. https://t.co/E9c46AEeTx
pnas.org
Cell-type-specific in vivo delivery of genome editing molecules is the next breakthrough that will drive biological discovery and transform the fie...
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Happy to see that my paper was a featured article in this special issue of Cell Chemical Biology featuring RNA. Go check out this awesome issue:
We kick off our 30th anniversary with a Special Issue on RNA Modulation with reviews & articles describing advances in our understanding of the structural diversity, function & regulation of RNA & harnessing this knowledge for therapeutic strategies. https://t.co/olISPG1y4D
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Do you want to know how much of your favourite m6A site is methylated? You can find out in *one day* using @AashiqHMirza's new method, SCARPET! Find out more about it here: https://t.co/upWTOb3jXi
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Our lab's very own @shino_murakami will be giving a talk about the interplay between ribosomes, amino acids, and m6A at the @Tri_I_RNA mini symposium! Sign up to hear from her and other amazing RNA scientists here: https://t.co/HsVcO8TwOx
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Weill Cornell and MSK friends, I will be participating in this years 3MT. Come by if you want to hear a fun 3 minute story on circular mRNAs in VLPs!
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Interested in expressing your mRNAs for a longer time? Want to have cell-specific targeting AND prolonged protein expression? Check out how @MildredUnti achieved this with translating circular mRNAs! Congratulations Millie!
Online now! Highly efficient cellular expression of circular mRNA enables prolonged protein expression by Mildred J. Unti @MildredUnti, and Samie R. Jaffrey @JaffreyLab at @WeillCornell #resource
https://t.co/a2fuiCqQDM
#chembiol
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Online now! Highly efficient cellular expression of circular mRNA enables prolonged protein expression by Mildred J. Unti @MildredUnti, and Samie R. Jaffrey @JaffreyLab at @WeillCornell #resource
https://t.co/a2fuiCqQDM
#chembiol
cell.com
Unti et al. describe the Tornado translation system, a highly efficient method for generating circular mRNA in cells. The Tornado translation system outperforms previous methods for generating...
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Our latest work by @michaelgeeson and @jeffreychsiao shows that NLRP1 associates with TRX1 using a transient disulfide bond. Their discovery showcases the predictive power of AlphaFold-Multimer!
biorxiv.org
NLRP1 is an innate immune receptor that detects pathogen-associated signals, assembles into a multiprotein structure called an inflammasome, and triggers a proinflammatory form of cell death called...
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I had a blast presenting my work at the @NYCRNASymposium. Overall a fantastic event with great science.
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Come join us to hear our very own @MildredUnti talk about expressing proteins from circular mRNA, among other great speakers! Also, catch several of our graduate students and postdocs at the poster sessions!
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Check it out!
Highly efficient cellular expression of circular mRNA enables prolonged protein expression https://t.co/txznzvgGgg
#bioRxiv
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Highly efficient cellular expression of circular mRNA enables prolonged protein expression https://t.co/txznzvgGgg
#bioRxiv
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Furthermore, we show that the Tornado translation system can be used to package circular mRNAs into virus-like particles to achieve cell-type specific delivery of a circular mRNA.
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We show that the Tornado translation system can be used for robust protein expression from a circular mRNA.
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We developed a new method, the Tornado translation system, for genetically encoding circular mRNAs. Unlike the backsplicing method, the Tornado translation system does not produce linear byproducts.
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My latest work entitled “Highly efficient cellular expression of circular mRNA enables prolonged protein expression” is now on bioRxiv (1/n)
biorxiv.org
A major problem with mRNA therapeutics is the limited duration of protein expression due to the short half-life of mRNA. New approaches for generating highly stable circular mRNA in vitro have...
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Registration and abstract submission for the 1st NYC RNA Symposium is open! Please spread the word!! https://t.co/8MzevQkter
@NYCRNASymposium
#NYCRNASymposium
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We had a great symposium with fantastic speakers, awesome audience, fun trivia, and food and drinks afterwards!! We thank our sponsors @ACDbio @AzentaSciences @TwistBioscience for making it possible! 👏👏
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