Michal Levo
@Michal_Levo
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Assistant Professor, Columbia University Medical Center. Transcription regulation. Genome topology. Live imaging. Quantitative Biology
NYC
Joined February 2017
So excited to join the Dept of Biochemistry & Molecular Biophysics @ColumbiaBiochem and the Program for Mathematical Genomics!!! I am extremely grateful to Stavros and many others for the warm welcome, and greatly looking forward to learning, discussing & collaborating together.
Supper excited to welcome Dr. Michal Levo at our department. Her elegant and creative approaches in the study of genome architecture and gene transcription will shed new light to the understanding of enhancer-promoter interactions and transcription dynamics in development!.
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RT @diegoisworking: Ecstatic to announce our latest project characterizing the continuum of regulatory and expression changes across the fi….
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RT @HFSP: HFSP Long-Term Fellow Michal Levo @Princeton and colleagues demonstrate that distant genes, separated by large genomic distances,….
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RT @eranhodis: How does a skin cell become melanoma? We built one to find out, to help understand this lethal disease. .
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(6/6).Micro-C (@XinyangBing) reveals pervasive long-range promoter–promoter connectivity of genes with overlapping expression patterns and shared enhancers. A single switch controls distant interconnected genes… Can we envision topological operons?
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(5/6).Promoter-proximal tethering elements facilitate co-regulation across a vertebrate-like promoter-promoter distance. Deletion of a single element (in green) maintains the proximal gene’s activity, but the distal gene never turns on in 1/3 of the nuclei.
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(4/6) .What underlies co-regulation?. CRISPR manipulations identify:. A shared enhancer underlying the activities of both genes in an anterior domain. Promoter-proximal elements, distinct from the enhancer, that allow for long-range tuning of transcription dynamics.
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(3/6).While 74kb apart, the co-regulated genes kni and knrl show physical proximity and transcriptional co-initiation events, within single nuclei.
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(2/6) .Simultaneous live imaging of transcription from two distant genes in living Drosophila embryos. Imaging in an anterior stripe domain of 2-3h embryos shows concurrent transcription of knirps (green) and knirps-related (red), in single nuclei (blue).
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Our paper is out! .Joint work with João Raimundo (@J_Raimundo_). Transcriptional coupling of distant genes in living embryos.@Nature . @XinyangBing, Zachary Sisco, @philippe_batut, @RyabichkoSergey, Thomas Gregor (@gregorscience) and Mike Levine. (1/6).
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RT @Anders_S_Hansen: (1/6) our preprint is now out in @ScienceMagazine Using super-res liv….
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RT @philippe_batut: Thrilled to share our latest work, now in @ScienceMagazine! Exploring how #3DGenome organization controls #transcriptio….
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RT @leeat_keren: I am very excited to announce that I am opening my lab for systems tissue pathology at @WeizmannScience ! We will use mult….
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RT @effiken: Our Crohn's disease scRNA-seq paper is online! We report on a cellular module comprising of immune & stromal cells enriched in….
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RT @VardiNoam: Our new paper is out! Dissecting viral circuits using an engineered virus, time-lapse microscopy and mathematical modeling.….
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RT @NatureGenet: Dynamic interplay between enhancer–promoter topology and gene activity (Chen et al.) https://t.co/….
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RT @segal_eran: Our new paper: Single cell measurements of both DNA binding and expression on thousands of promoters in parallel https://t.….
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