MetaStem
@MetaStem_Center
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Centre of Excellence in Stem Cell Metabolism @KatajistoLab @HTyynismaa @HietakangasLab @OtonkoskiL @JetteLeng https://t.co/xszN6BWQvl
Helsinki, Finland
Joined October 2017
Follow MetaStem, The Centre of Excellence in Stem Cell Metabolism on Bluesky 🦋 Seuraa meitä Blueskyssa
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News from our CoE by @KatajistoLab Andersson et al found that intestinal stem cells with old mitochondria make Paneth cells faster due to higher aKG levels and aKG improves regeneration in old animals by Paneth cell renewal @SuomenAkatemia @helsinkiuni.
nature.com
Nature Metabolism - Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
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News from our CoE by @OtonkoskiL @EliisaVhk et al show that upon engraftment into mice stem cell derived pancreatic islets become insensitive to pyruvate, correlating with down regulation of pyruvate/lactate transporter MCT1 @SuomenAkatemia @helsinkiuni.
link.springer.com
Diabetologia - The use of stem-cell-derived islets (SC-islets) as a source for cell-based therapy of type 1 diabetes shows great potential. However, SC-islets have a metabolically immature...
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RT @KatajistoLab: Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Pan….
nature.com
Nature Metabolism - Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
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News from our CoE by @HTyynismaa group characterize the role of mitochondrial intermembrane space protein CHCHD10 in metabolism and spinal muscular atrophy Jokela type (SMAJ) Congratulations Sandra Harjuhaahto! @SuomenAkatemia @helsinkiuni @STEMMProgram.
actaneurocomms.biomedcentral.com
Dominant defects in CHCHD10, a mitochondrial intermembrane space protein, lead to a range of neurological and muscle disease phenotypes including amyotrophic lateral sclerosis. Many patients present...
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New from our CoE by @KatajistoLab show how tissue stem cells can metabolically regulate tissue renewal and differentiation by providing daughter cells with peroxisomes of different age and metabolic properties @SuomenAkatemia @helsinkiuni @HiLIFE_helsinki.
nature.com
Nature Communications - Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in...
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A new study from our CoE finds that stem cells can control whether they self-renew or differentiate by localizing certain metabolic reactions differently @SuomenAkatemia @helsinkiuni @KatajistoLab @BIOTECH_UH @MIBS_Helsinki @_HienBui @PekkaKatajisto.
helsinki.fi
A new study sheds light on the mechanisms that regulate how our tissues develop and are constantly renewed to keep up their function. In the future, these results might contribute to the understand...
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RT @KatajistoLab: Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells http….
nature.com
Nature Communications - Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in...
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RT @MetaStem_Center: Next Stem Cell Seminar April 23rd, welcome! @HelsinkiUniMed @HiLIFE_helsinki @STEMMProgram @BI….
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Next Stem Cell Seminar April 23rd, welcome! @HelsinkiUniMed @HiLIFE_helsinki @STEMMProgram @BIOTECH_UH @FIMM_UH.
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RT @stemcellpodcast: The @KatajistoLab modeled #epithelial regeneration using small intestinal scaffolds and identified #asporin is a media….
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RT @MetaStem_Center: Welcome to the next Metabolism seminar, March 18th at 9-11 am in Meilahti. Excellent speaker lineup with and @DrPieti….
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In the future, ads for these seminars will move to Bluesky 🦋 Follow us there
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Welcome to the next Metabolism seminar, March 18th at 9-11 am in Meilahti. Excellent speaker lineup with and @DrPietilainen and Robin Cristofari groups presenting about #obesity #adiposetissue #diet #aging in humans and penguins @STEMMProgram @BIOTECH_UH @HelsinkiUniMed
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RT @CellStemCell: Online Now! Fetal-like reversion in the regenerating intestine is regulated by mesenchymal asporin .
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RT @KatajistoLab: Proudly presenting Sharif’s paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like re….
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Tomorrow, welcome!.
Excited to have @HKilpinen and special guest @ChristianGoritz opening the Stem Cell Seminars of 2025 with focus on neurodevelopment, regeneration and fibrotic scarring in the CNS. Jan 23rd 9 am, welcome! @MIBS_Helsinki @BIOTECH_UH @LifeSciHelsinki @HelsinkiUniMed
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RT @MetaStem_Center: Welcome @ChristianGoritz on Jan 23rd. Excited to hear about your research on perivascular fibroblasts, scarring and re….
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New collaborative study of @HannesLohi lab together with @HTyynismaa lab @julius_ronkko from our CoE. Surprising findings in Lancashire Heeler dogs shed light on CMT disease mechanisms Congratulations to all authors! @helsinkiuni @SuomenAkatemia.
journals.plos.org
Author summary We investigated pet dogs, Lancashire Heelers, with impairments in tooth development and in the nerves that regulate limb muscles. Through genetic studies of the dog pedigree, we found...
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Welcome @ChristianGoritz on Jan 23rd. Excited to hear about your research on perivascular fibroblasts, scarring and regeneration of the central nervous system. The seminar is part of the Stem Cell Seminar series and open to all @LifeSciHelsinki @HelsinkiUniMed @HiLIFE_helsinki
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