Mengqi Chai
@MengqiChai
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Postdoc researcher in Gross research group #MassSpectrometry #MembraneProteinFootprinting #timsTOF
St Louis, MO
Joined April 2017
Happy Holidays everyone!
Our alumni, @MengqiChai, back in the lab to celebrate the Holidays with us @jl16n @thapedrete @FannyCLiu @BrooksieChand15 Happy Holidays, Everyone! Merry Christmas 🎄🎁🎄!
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Metastability of Protein Solution Structures in the Absence of a Solvent: Rugged Energy Landscape and Glass-like Behavior | Journal of the American Chemical Society @FSUResearch @FloridaState #Protein #Strutcure #Solvent #Landscape #Glass #Behavior
pubs.acs.org
Native ion mobility/mass spectrometry is well-poised to structurally screen proteomes but characterizes protein structures in the absence of a solvent. This raises long-standing unanswered questions...
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Wow, online already!
Ever wondered how proteins unfold without solvents? In our most recent paper @J_A_C_S , we unveil a striking similarity between solvent-free and solution-phase protein unfolding using Tandem-TIMS & Structure Relaxation Approximation method. https://t.co/pI94GPiZK3
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Fancy cool Mass Spec kit? Enjoy working with structural biologists and push boundaries of native MS, ion mobility, HDX-MS and crosslinking? We have just the job for you, in the Facility: https://t.co/qkzTpCCLMC.
jobs.leeds.ac.uk
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Travel stipends due this Friday to attend the workshop on March 11.
Application for student travel stipends due on Friday, January 19 for the Spring Workshop on Protein Structure Elucidation with Ion Mobility Spectrometry/Mass Spectrometry. @asmsnews @FemalesInMS @J_ASMS
@FSUResearch @FSUartssciences @ChemistryFsu
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Structure Relaxation Approximation (SRA) indicates that a ~10% increase in hydrophobic content of the protein surface renders protein complexes metastable in the absence of solvent. https://t.co/01QWwWrBPY
@JPhysChem @ACSPublications @FSUResearch
pubs.acs.org
Characterizing structures of protein complexes and their disease-related aberrations is essential to understanding molecular mechanisms of many biological processes. Electrospray ionization coupled...
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Thanks Eric for this paper! It's one of those I'm most proud of! How to probe G-Quadruplexes nucleic acid biophysics with native HDX-MS
Very happy to share our long overdue @J_A_C_S publication on HDX/MS of G4s, with @ValerieGabelica and Matthieu Ranz. Thanks to @arna_lab/@iecb_bordeaux/@AgenceRecherche for support and @HdxMs for being a lovely community open to non-traditional approaches
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Check out these snaps from last week's Golden Anniversary Herron Symposium of FT-ICR Mass Spectrometry at @FloridaState. Thank you to everyone who came out! 🎉 Learn more about the symposium on our website: https://t.co/GpH7jMtaNa
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Please RT! Two exciting faculty positions are available to join us in Biological Sciences at UNC Charlotte: a Belk-endowed Associate Professor (tenured) position ( https://t.co/E5XDwMtD0O) and an Assistant Professor (Physiology) ( https://t.co/QUSIyf4hdg)
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Check out our latest paper by @N_Brundridge paper utilizing different activation methods to tease out G-Quadruplex formation!! https://t.co/VPDxoJjAFX
pubs.acs.org
G-quadruplex (G4) DNA is found in oncogene promoters and human telomeres and is an attractive anticancer target. Stable G4 structures form in guanine-rich sequences in the presence of metal cations...
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Please RT. Save the date: Golden Anniversary Symposium of FTICR in honor of Alan Marshall on November 3, featuring many renowned speakers. Free in-person and online registration link coming soon: https://t.co/J2sXxMYiHr
chem.fsu.edu
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Here is the one from #asms2019. I am still young and foolish to science.
Bleiholder lab dinner at Gen korean bbq #ASMS2023
@araoyinbo18 @VRAdoesMS @thapedrete @MengqiChai @FannyCLiu
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Happy to attend #ASPET2023 for the first time and be a co-presenter for a poster later tomorrow! Thanks for the support from Gross lab and Scott lab!
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Excited to share my first video on @YouTube 😊 Big thanks to @g4interact organizer @VaLePirota for recording my tutorial lecture "Mass spectrometry to study G-quadruplex biophysics" https://t.co/xzwSdJsVre
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Please RT. The 2023 Summer School on Computational Tools for Structural Interpretation of Ion Mobility Spectra will be held on March 13-15. Apply until Jan 31 for travel stipends for in-person attendance. @asmsnews @ISIMSSociety @FemalesInMS
chem.fsu.edu
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Go tandem!
New Research: Perspective on the potential of tandem-ion mobility/mass spectrometry methods for structural proteomics applications https://t.co/UeJpsXeOif
#AnalyticalScience
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An interesting report discussing the various instrument parameters needed to accurately measure fragile, noncovalently bound oligomers formed during early stages of peptide aggregation using trapped ion mobility(TIMS)-MS! @anoukrijs
https://t.co/az5TIgZQfS
pubs.acs.org
Ion mobility mass spectrometry (IM-MS) has proven to be an excellent method to characterize the structure of amyloidogenic protein and peptide aggregates, which are formed in coincidence with the...
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Check it out! Congratulations to Jusung!
In his first first-author paper, Jusung shows how TIMS2-MS2 workflows provide a general approach to differentiate isomeric, non-separable carbohydrates. #tandemTIMS #carbohydrates @an_chem @asmsnews @ISIMSSociety
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