
Matthew Ho
@MatthewHoMD
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@pennmedicine Heme/Onc Fellow via @UCDmedicine; @thebianchilab; @mayoMN_imres
Philadelphia, PA
Joined July 2020
🧵A brief thread on #CardiovascularSurgery and #PCI approaches for patients with heparin-induced thrombocytopenia (HIT) 🩸 Happy to share our review on this topic was recently published: https://t.co/PGsjBHIj1z
#hemetwitter #hemesky #classicalhematology *not covering aHIT 1/8
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Check out our latest episode "The Aquila Study: Blowing Hot Air or a Soaring Success for Smoldering Multiple Myeloma" with @ManniMD1 @ajperissinotti and @Berninini 🦅💨 #myeloma #badblood
creators.spotify.com
AQUILA is a constellation shaped like an eagle, and also a hotly debated myeloma trial of daratumumab in smoldering multiple myeloma. In this episode, Bernie and Anthony are joined by myeloma expert...
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Simple concept of GN. It’s all about location! 1. Subendothelial deposits/injury by Ig, immune-complexes, complement, other mechanism leads to influx of leukocytes= inflammation=GN 2. Subepithelial deposits/injury= protected by GBM & endothelial cells=no inflammation=No GN. 1/3
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1/6 TPE-FREE MANAGEMENT OF IMMUNE TTP (iTTP) Retrospective study from Austria and Germany ADAMTS13 activity at baseline <10% in all patients Treatment group (TPE-free): 42 acute iTTP episodes in 41 patients received TPE-free management with caplacizumab + steroids +/- Ritux
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A comprehensive review in @BloodJournal on risk stratification/scoring in MPNs https://t.co/XvYJlCh0CJ
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Here is our article that defines and disambiguates both #ockhamsrazor and #hickamsdictum for #differentialdiagnosis
https://t.co/U33hbXLvaW And a blog post with additional information: https://t.co/bM53mUf40u And tweetorial as promised
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Our first RCT on using an LLM on diagnostic reasoning is out! And the results are 🔥🌶️... adding ChatGPT did NOT improve diagnostic accuracy or reasoning, and the AI alone outperformed ALL the humans. What does this mean? A 🧵⬇️ https://t.co/MgkhrrkKmT
A small randomized trial of generative #AI for diagnosis again (as seen in a few previous studies) shows higher performance for #AI than physicians + AI. May indicate that physicians need to be trained on how to incorporate AI. https://t.co/UXpU49PbfA
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1/ Challenge accepted. I have run a series of breast mammograms (x-rays), ultrasounds and MRIs through versions of GPT4 and posted the results here previously. Even though it's data contamination to repost images I already used on X, it's an easy bench mark. So how did Grok do
Try submitting x-ray, PET, MRI or other medical images to Grok for analysis. This is still early stage, but it is already quite accurate and will become extremely good. Let us know where Grok gets it right or needs work.
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🆕 Infographic on Systemic Lupus Erythematosus! • Recognize signs/symptoms of #lupus and when SLE should be on your DDx • Learn what labs to send if you suspect SLE: And don’t forget to ☑️ UA/UPC ratio! 🫘 #RheumTwitter #MedX #MedTwitter #NephTwitter #Rheumatology
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Great reminder that Na delivery to distal tubules and aldosterone needed for kaliuresis. - diuretics (including caffeine) increase Na delivery to distal tubules —> k loss - hypovolemia decreases Na delivery to distal tubules —> reduction in K excretion
Hypokalemia #Nephpearls and the most interesting case I have ever heard of — Rhabdomyolysis from Caffeine (Coffee/Cola)-Induced Hypokalemia‼️ by @VelezNephHepato @OchsnerNephro @ASNKidney #KidneyWk ☕️ @NYUnephro fellows discussing how much caffeine we’ve taken for exams! LOL!
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Pseudo-AKI - some drugs cause an increase in creatinine due to decreased creatinine secretion. Cystatin C will be normal. #KidneyWk
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Hey #NeuroTwitter , check out my #neuromuscularbuckets. It's a method to work backward when evaluating patients with neuromuscular disorders. Sometimes you know the patient has a peripheral nerve disorder, but you get stuck on where to go next. That's where the buckets are
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Approach to Atrial Fibrillation (Rate vs Rhythm Control) Ref: uptodate, AHA 2023, Mayo IM board review course (Dr Abhishek Deshmukh)
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Approach to anticoagulation in atrial fibrillation Anyone using CHA2DS2-VA (omitting sex) to predict risk of stroke?
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@MatthewHoMD This looks great! Here is our version of an approach to HLH/MAS — made with @nickmmark !
🆕OnePager on Hemophagocytic Lymphohistiocytosis (HLH) / Macrophage Activation Syndrome (MAS), created w/ @nickmmark ☔️ Cytokine Storm 🫁 Multi-Organ Failure 🌡️ Fever 🩸 Cytopenias/↑ Ferritin 🦠 Infection, Autoimmune, Cancer #MedTwitter #FOAMed #RheumTwitter #HemeTwitter
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1/ I once heard that a fever in the ICU was a "fever of too many origins." Same can be said altered mental status/encephalopathy! We put together a comprehensive approach to these challenging patients for #SeminarsinNeurology A thread with our approach! https://t.co/VK9Dm1v8iQ
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Attended on our medicine consult service for 1 day Here are 5 teaching points that came up #MedTwitter #FOAMed #HospitalMedicine #NewsYouCanUse
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1. Which prophylaxis do you chose after a hip or knee surgery? Simplistic: ASA=LMWH Correct: ASA has similar mortality & PE as LMWH but 1-2% more uncomplicated DVTs In people at very high VTE risk, may consider LMWH if convenience & cost not an issue https://t.co/bagoTkLX6y
New @NEJM pragmatic trial says aspirin is same vs LMWH after fracture Last summer a JAMA cluster RCT study said aspirin was worse after hip/knee replacement In reality both say the same thing LMWH has similar mortality but 1-2% less VTE within 90 days https://t.co/CLHlk3lsYO
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