Máté Kiss
@Mate_Kiss_
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Postdoctoral researcher @PittetLab interested in cancer immunology.
Lausanne, Switzerland
Joined December 2014
Our new paper is out:.Tumors don’t just reprogram monocytes locally. We show in a mouse model that the systemic impact of a tumor can alter the epigenome of peripheral monocytes, repressing IFN-responsive genomic sites and priming pro-tumor gene programs.
genomemedicine.biomedcentral.com
Background Monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones...
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RT @carmonation: 📢 We have an open position at University of Geneva @unige_en for a PhD student with CS/Math/Physics background to study ad….
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I am grateful to co-lead authors @HalaszLaszlo and @EvaHadadi, and everyone involved from the labs of Jo Van Ginderachter, Damya Laoui (@VUBrussel, @InflamResCen) and @LaszloNagyLab (@HopkinsMedicine, @AllChildrens).
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RT @Satpathology: Clone tracing T cell responses in cancer (using TCR-seq methods) has been incredibly valuable for understanding immunothe….
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RT @vincentzliu: For innate immune cells, the lack of diverse receptor rearrangements has prevented the study of clonal evolution of the in….
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Happy to share that I’ll be starting my lab as a junior group leader at the Georg-Speyer-Haus in Frankfurt in 2026. We’ll study how transcriptional regulators control neutrophil function in cancer. I’ll be hiring soon (PhD/lab tech), pls reach out if you know someone interested!.
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Very cool!.
1/23 We are excited to announce that our most recent study “In vivo dendritic cell reprogramming for cancer immunotherapy” was published in @ScienceMagazine. Here is a summary of what we discovered!.
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RT @camillaengblom: Engblom lab is hiring a post-doc ! Come join our team to study B cell clonal dynamics in cancer @scilifelab @karolinska….
ki.varbi.com
Vill du bidra till medicinsk forskning av toppkvalitet? Kom och anslut dig till Engblom-labbet! En postdoktorandposition är tillgänglig i skärningspunkten mellan immunologi, cancer och spatial tran
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Please check out the preprint for more details! This work was the result of a close collaboration between @Laouimmunology, the lab of Jo Van Ginderachter (@VUBrussel, @InflamResCen) and @LaszloNagyLab (@HopkinsMedicine, @AllChildrens).
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We also detected epigenetic priming in peripheral monocytes at promoters of genes previously linked to tumor-promoting functions (e.g. Trem2, Cd38, Thbs1, Myc).
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This epigenomic programming affected functionally important genes. For example, promoters/enhancers that are responsive to immunostimulatory interferons (harboring IRF or ISRE TF binding motifs), were repressed genome-wide in monocytes already before their arrival to the tumor.
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We could link these epigenetic changes in peripheral monocytes to sustained induction/repression of neighbouring genes, which persisted after tumor infiltration. We also observed epigenetic priming in peripheral monocytes at genes that were activated only later in the tumor.
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By analyzing various histone modifications (H3K4me3, H3K4me1, H3K27ac) and chromatin accessibility genome-wide, we found that peripheral monocytes in tumor-bearing hosts show extensive epigenetic alterations at their promoters and enhancers.
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Excited to share our work with @HalaszLaszlo, now on bioRxiv, on how the systemic effect of a tumor can remodel the epigenomic landscape in peripheral monocytes and shape how they respond to the tumor microenvironment.
biorxiv.org
Classical monocytes are recruited to tumors and undergo transcriptional reprogramming resulting in tumor-promoting functions. Epigenomic features, such as post-translational modification of histones...
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RT @beatricezitti: 🌟 Tun in for the next Seminar Series organized by the @syis_ecr and hosted at the #AGORA Cancer Research Center in beaut….
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RT @GfellerD: Building and analyzing metacells in single-cell genomics data | Molecular Systems Biology
embopress.org
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RT @beatricezitti: Keeping up with traditions 😎 @PittetLab enjoying the science. and the fun at our annual #PATIM retreat 👩🏻🔬 thanks @jand….
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RT @TheCrick: 🎟️ Free tickets are still available for our #MedicineAtTheCrick event next Thursday!. Hosted by @charlesswanton, researchers….
eventbrite.co.uk
Hybrid event taking place virtually and in person, organised by The Francis Crick Institute, London
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RT @Gapminder: We just published three homes from South Sudan 🇸🇸 on @dollarstreet_ . When you see what “$70 per month” looks like in realit….
gapminder.org
The family lives in South Sudan. They are 3 adults and 3 children. AD is 43 years old and she is a farmer. She lives with her 3 sons and 3 daughters in a 2-bedroom house. They have been living here...
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RT @GCIR_Unige: Are you an #immunologist looking for a job? . 🚀@GCIR_Unige Prof. Christoph @ScheiermannLab is hiring!🚀. ➡️Lab website: http….
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