Matthew Todd
@MatToddChem
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Chair of Drug Discovery at @UCL. Founder, #openscience drug discovery consortia @O_S_M @MycetOS @OSantibiotics. Head, Open Chemistry Networks @thesgconline
London, England
Joined February 2009
Most days I love my research group. But there are some days when I *really* love them. #OpenScience #outreach on our lab's windows in central London @School_Pharmacy. Open science is #inclusive, and drug hunters could be walking right here... @O_S_M @MycetOS @OSantibiotics
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Cycling in to @School_Pharmacy again, first time since COVID. Things that have changed: 1) Lime bikes, flocking like pigeons. 2) 50% of cyclists have ear buds in. If you don't do it in lab, don't do it on the road, people.
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Perhaps surprisingly, we had a talk today from @NASA in @School_Pharmacy providing, finally, a chance to wear my old @NASAVoyager T.
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Weird wardrobe reversal with @aledmedwards at local @School_Pharmacy pub @SkinnersArms1 @thesgconline
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Are you a computational chemist who loves #orgchem mechanisms? We could use a hand in this #openscience project relevant to new #antiviral molecules. Which mechanism is expected to operate in solution? More details at https://t.co/wE5EUfcCrO
@RahmanSZSaleem @thesgconline
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Taking #openscience contributions to the next level. @WhitgiftSchool1 has provided their talented students, who have successfully made molecules for @MycetOS, with their own cool, branded labcoats. I have to get me one of those. @DNDi #mycetoma #NTDs
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Seriously long shot, but is anyone running the #baytobreakers race in San Francisco this Sunday, and willing to pick up a bib packet at the race expo (Berkeley or Presidio) for a Brit who is arriving too late to do so..?
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#GetInvolved with #openscience. We've identified #fluorosulfonyls as favored warhead for #DENV RdRp. Details at https://t.co/knnz3tn9au. Do you have #fluorosulfonyls? We would love to test them! #antiviral
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A combination of biochemical, structural, and modeling studies identifies OSM-S-106 as an exemplar of a new chemical class of species-specific reaction hijacking inhibitors. @MatToddChem
#malaria #AntimalariaResearch #DrugDiscovery Read more:
nature.com
Nature Communications - New antimalarials are urgently needed. Here, the authors identify Open Source Malaria compound, OSMS-106, as a reaction hijacking inhibitor of the malaria parasite protein...
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Interested in synthesis and synthesis prediction? @s_marsden and I have a PhD studentship that is collaborative with @Exscientia. Enhanced stipend. Open to UK students (and, in competition, to international applicants)
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Deeply fun to welcome students from @WhitgiftSchool1 to @School_Pharmacy @UCLLifeSciences to analyse samples of a molecule they made for the #openscience drug discovery project @MycetOS We NMR'd, we mass specced, we figured it out. https://t.co/gqWPd8eOBX
@ResearchInSch
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Love #orgchem? Love palladium catalysis? Love the Miyaura borylation? We do, but there's one we can't get working. We need it to enable high value compounds for #malaria in @O_S_M. See https://t.co/gcjNKLaspQ for more. #openscience @yinuo_w @MedsforMalaria @thesgconline
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John Moult kicking off the CACHE Challenge Symposium in Toronto, describing the lessons learned from the CASP protein structure prediction competition @thesgconline
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Yesterday's board dinner of @thesgconline at @UofT Faculty Club with @aledmedwards @HalabelianLab @mattschap @ryanmerkley @LabScribbles @CherylArrowsmi1 (& others not on X..). Such a fun group of talented researchers who advocate, and *do*, #openscience.
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Fragments and #openscience ftw! We've 18 frags bound at the interface of SARS-CoV-2 Nsp10 and Nsp14, and now we need to grow/merge/link. Details at https://t.co/kxmqD5E8Ca Live and online at Fragalysis https://t.co/cwCiNugjyO We can buy/make/measure. @thesgconline #antiviral
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An #openscience project needing community help from computational modellers. WDR91 for host-directed antivirals. We've binders + xstal structure. We need to understand the data, particularly the matched pairs. https://t.co/tgLYOlIVjy
@thesgconline @target2035 @UCLLifeSciences
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Several #openscience projects in the lab are nicely poised for community inputs. Here's a peach. One of the @thesgconline Open Chemistry Networks needs some simple ureas. You make, we test. Protocols available. https://t.co/g9FRhWmnY1
@target2035 @UCLLifeSciences
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“Reaction Hijacking” Antimalarial Discovered! UCL School of Pharmacy researchers contributed to an open-source project resulting in a novel molecule targeting the #malaria parasite. Read more here: 👇 https://t.co/3VpKl5o9oh
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