Adam Martin
@MartinLabMIT
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Associate Professor @MITBiology. Interested in how cells generate force and how they work together to sculpt tissues.
Cambridge, MA
Joined July 2019
Watch the movies while reading our newest. Great work from Jasmin Imran Alsous, with @NicolasRomeo17, Jonathan Jackson, and @frank_m_mason. Another great collaboration with Jörn Dunkel's group who provide the critical connection to balloons. @MITBiology
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RT @ChemistryMIT: Check out this excellent profile of Professor of Chemistry and @MITBiology Catherine Drennan (@Drennan_Lab) recently pub….
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Join us at the 2025 Cell Contact and Adhesion @GordonConf. Great people and great science!.
Cell and developmental biologists--Join us at the 2025 Cell Contact and Adhesion @GordonConf. We've assembled a strong and diverse program of speakers at the cutting-edge of science in our field 1/n Please RT.
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Thus, we showed a relay system that doesn’t just result in a wave of the same shape change, but a trigger mechanism for one mode of morphogenetic change jump-starting another.
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These cell adhesion complexes serve as a scaffold to recruit actomyosin through patterned mechanical feedback. Thus, EGFR + mechanical pull recruits actomyosin. Work from @StreichanS demonstrated this patterned feedback and we showed that it is linked to EGFR.
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We identified a mechanism that regulates both Drosophila mesoderm internalization and body axis extension. We showed that EGFR signaling, whose earliest known embryonic role was patterning the central nervous system, establishes a DV pattern of graded levels of cell adhesion.
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Pleased to share the publication of our paper showing the role of EGFR in coordinating morphogenetic movements in Developmental Cell. Congratulations @MITBiology postdoc, @natclarke8 for all your hard work! .Article:
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Online now: Postdoc Nat Clarke's @natclarke8 excellent work on a mechanism that coordinates tissue folding and axis extension. Great job and congratulations Nat!.
Online now: EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster
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RT @PracheeAC: IMO in career decisions, too many people optimize for what they think they’re entitled to when instead, opting into cool shi….
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RT @rburdine1: I am incredibly excited and honored to be running for the Secretary position for the Society of Developmental Biology! If y….
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So much successful science involves people behind the scenes making the jobs of faculty, students, and postdocs possible. They don't often get the recognition they deserve, but are truly appreciated by those they support. Great job John Fucillo, you are a pleasure to work with!.
Building 68 manager John Fucillo’s leadership, innovation, and laid-back attitude have built a community culture that will never be taken for granted. #staffspotlight
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Congrats to @natclarke8 and Uzuki Horo for their study being highlighted by @ASCBiology.
FROM MBoC. This study unravels the complex dance of the cytoskeleton during Drosophila gastrulation, revealing how Fog/Cta & T48 pathways uniquely & collectively guide early embryo development. @mShaneHutson @MIT @MartinLabMIT
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RT @peiferlabunc: Dear Colleagues--@MartinLabMIT , @LindsayCase19 and I are starting to plan the 2025 Cell Contact and Adhesion GRC. One t….
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Overall, we showed that the Fog/Cta and T48 pathways have overlapping and distinct roles in the development of the Drosophila embryo. These pathways regulate RhoA and so this informs on potential signaling logic for the RhoA pathway in other systems.
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Not to be outdone, T48 mutants also had distinct effects. While affecting myosin accumulation in tissue folding, T48 mutants also affected earlier stages of development, exhibiting defects in cellularization and egg shape. Consistent with this, T48 is maternally deposited.
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Fog/Cta and T48 pathways are thought to function in parallel in tissue folding. Using this porosity measurement that he found and adapted, Uzuki found that while both pathways similarly reduce myosin, Fog/Cta pathway affected network continuity more that T48 mutants.
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Excited to have submitted manuscript by @MITBiology @urop_mit Uzuki Horo. @natclarke8 mentored Uzuki and pushed the project to completion. We discovered how Fog and T48 pathways distinctly regulate myosin activation.
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RT @ScienceMIT: According to Jay Stein PhD ’68, the Jay A. Stein (1968) Professorship of Biology at MIT "is a way to pass the baton of scie….
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"The cytoskeleton is boring". Ironically, I also started grad school with the thought that I would NEVER work on the cytoskeleton.
Cell biology is . truly awesome. My take on what cell biology means to me in the latest issue of @CellCellPress celebrating their 50 years. I really enjoyed reading the pieces from everyone.
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RT @REMLehmann: Here is an open link to: Basic Science is not just a Foundation. (Nature Cell Biology, Volume 26, pages 8–10 (2024): https:….
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RT @RusanLab: I am hiring in 2024. Contact me if you'd like to learn about my lab and the NIH
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