Margulies Lab
@MarguliesLab
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Translational research lab at @PennCVI @PennMedicine studying heart failure
Philadelphia, PA
Joined August 2022
Welcome to the Margulies Lab twitter! We’re excited to be here and share all things heart related 🫀
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In KETO-HFpEF, we integrated CPET, echo, lung US, tonometry, metabolites, isotope tracer, & leg MRI. Ketone ester didn't ⬆️ exercise, despite ⬇️filling pressure & glucose use at rest/exercise Simpub #ACC25 #JACCHF 🙏 #PZamani @MarguliesLab &team @PennCardiology @DukeHeartCenter
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From monocytes pulling matrix by @KoladeAdebowal1 to cardiac in vitro models by Benjamin Lee from @MarguliesLab we continue the mechanobiofun at #cmbes2025 @ucsdbe @PennMedicine @PennCVI @UCSDJacobs
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Our phase I study of 2 doses of exogenous ketones detailing PK and metabolic profiling in HFrEF by background SGLT2i Simpub #AHA24 & @JACCJournals #JACCBTS
https://t.co/iIR6V17X3i 🙏 @SvatiShah @MarguliesLab @robmentz @FudimMarat and outstanding team @DukeHeartCenter @DukeMPI
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Congratulations @mikeibrahimmd !!
The @STS_CTsurgery has awarded @mikeibrahimmd 🩺 funding to research t-tubule remodeling in the cardiac muscle cells of people w/ #heartfailure. This is the 1st time the award 🏆 has been granted to a cardiothoracic surgeon. Learn more ⬇️
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Congratulations to @AlexiaVite93 on placing in the Lightening Talk competition at @ISHR_NAS meeting in Long Beach, CA
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We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first!
biorxiv.org
Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant...
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Small molecules that inhibit vasohibins and alpha-tubulin #detyrosination can promote myocardial relaxation and counteract heart muscle cell stiffness in a rat model of #HeartFailure with preserved ejection fraction. @MarguliesLab @Prosser
https://t.co/pfvLktEr6T
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Can we "drug" microtubule modifications to lower cardiac stiffness and improve function in #HFpEF? Out now in @ScienceTM , w/ long time collabs in @MarguliesLab 1/5 https://t.co/gtcpuo7dFI
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A new study by @Prosser_Lab and @MarguliesLab found that inhibiting vasohibin reduced heart muscle stiffness. This could lead to new treatments for heart failure with preserved ejection fraction (HFpEF)
science.org
Blocking α-tubulin detyrosination with a small-molecule inhibitor improves myocardial relaxation in the ZSF1 obese rat model of HFpEF.
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Congratulations Alexia Vite! Awarded the American Heart Association’s Career Development Award and the Second Century Early Faculty Independence Award
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Congratulations to lab member/Research Assistant Professor @AlexiaVite93 on being awarded both (!!) the AHA CDA and Second Century Early Faculty Independence Award!
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Excited about our latest work in @JMCCPlus showing colchicine improves diastolic performance in myocardial slices. Congrats @EmmaleighHancoc and thanks to Brad Palmer, @IonOptix , @UVMLarnerMed , and @uvmcvri for making this possible! https://t.co/wb2o6q8wPT
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New research examines the functional impact of alternative metabolic substrates in failing human cardiomyocytes ft. @AlexiaVite93, Timothy Matsuura, @kbedi88, Emily Flam, @AranyLab, @DanKellyPennCVI & @MarguliesLab (@PennCVI/ @PennCardiology) https://t.co/dcItU0LTnS
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Mechanical memory of human iPS-derived fibroblasts and cardiomyocytes. https://t.co/WsQIAUvstf
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In our new study led by @NesrineBouhrira , we explore how rapid induction of stiffness-induced mechanical memory in cardiomyocytes suggests potential interventions for maladaptive myocardial stiffening @BasicResCardiol @AlexiaVite93
link.springer.com
Basic Research in Cardiology - Recognizing that cells “feel” and respond to their mechanical environment, recent studies demonstrate that many cells exhibit a phenomenon of...
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Congratulations Benjamin Lee! Received the American Society for Clinical Investigation's Emerging-Generation Award
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Using #cardiomyocytes from failing hearts, @MarguliesLab found that these cells exhibit metabolic inflexibility, relying on non-carbohydrate sources for contractility. Read the new #JACCBTS study by @AlexiaVite93, et al here: https://t.co/pw7WJWBDQG
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