Marcela Moncada-Velez
@Marce_MoncadaV
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Scientist @CasanovaLab working in human genetics, immunology and molecular biology of primary immunodeficiencies (PID)
New York, NY, USA
Joined March 2020
RT @alexbolze: What is the cause of RARE cases of myocarditis following COVID-19 mRNA vaccination? . Read our hypothesis & our plan to answ….
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RT @casanova_lab: 1/ Free registration is still open for this week's 29th Annual Henry Kunkel Society virtual meeting on "Innate Immunity:….
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RT @RockefellerUniv: Paul Bastard of the @casanova_lab and @Inserm has won the @MichelsonPhils & @ScienceMagazine Prize for Immunology for….
science.org
Autoantibodies that neutralize type I interferons increase with age
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Great review!!!.
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Congratulations Jean-Laurent @casanova_lab, very well deserved!!!!.
📣 Prof. Jean-Laurent Casanova (@casanova_lab), researcher at @RockefellerUniv, has been chosen as winner of the @AbarcaPrize for his study of #infectiousdiseases, including Covid-19, and for solving the “infection enigma”. Details of the statement: ⬇ .
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Second great research from our group with the help of many scientists, physicians and patients!!!.
1/ In this 2nd @SciImmunology paper (, we show pre-existing auto-Abs neutralizing low physiological concentrations of type I IFNs account for 15% of critical COVID-19 cases, including 20% of critical cases in patients >80 yrs and 20% of deaths across ages.
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Happy and honored to be part of this great research!!! Huge effort not only of people like me were doing experiments but also from physicians and patients around the world.
1/ In this first @SciImmunology paper (, we show that at least 1% of men younger than 60 years with life-threatening COVID-19 are sick because of X-linked recessive (XR) TLR7 deficiency.
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RT @ALNeehus: Happy to share my first PhD paper investigating the mechanism by which human PKCD deficiency underlies susceptibility to infe….
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RT @BustamanteJaci1: Genetic, Immunological, and Clinical Features of 32 Patients with Autosomal Recessive STAT1 Deficiency .
pubmed.ncbi.nlm.nih.gov
Autosomal recessive (AR) STAT1 deficiency is a severe inborn error of immunity disrupting cellular responses to type I, II, and III IFNs, and IL-27, and conferring a predisposition to both viral and...
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RT @BustamanteJaci1: Congratulations to Tom Le Voyer for his important contribution in the first international cohort of patients with auto….
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RT @ShenYingZhang1: Officially published too! Again, TLR3, type I IFN, and the central nervous system. :).
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RT @BustamanteJaci1: Our new work about Gata2 defiency & mycobacterial infectious diseases is online at J Clin Imm..
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🦠 Te esperamos en una sesión más del Foro Reflexiones #COVID19. —Hablaremos sobre "Inmunidad de interferón (IFN) tipo I deteriorada en pacientes con COVID-19 potencialmente mortal" con el Dr. Jean-Laurent Casanova y el Dr. José Luis Franco. 🔴
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RT @RockefellerUniv: Just how sick we get from #COVID19 depends on genetic variations, including ones that sabotage immune molecules called….
knowablemagazine.org
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RT @casanova_lab: Rogue Antibodies and Gene Mutations Explain Some Cases of Severe COVID-19 – NIH Director's Blog
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RT @GarvanInstitute: Garvan’s Prof Stuart Tangye, in collaboration with KU Leuven's Prof Isabelle Meyts, has co-led a multi-centre internat….
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RT @NewsfromScience: Two papers published online this week in Science, about hidden immune weakness in gravely ill #COVID19 patients, expla….
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RT @casanova_lab: Here is the first paper, which shows that variants in only 13 influenza susceptibility candidate genes that govern TLR3-….
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RT @casanova_lab: Here is the other paper, which shows that neutralizing auto-Abs to type I IFNs account for at least 10% of critical cases….
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