Matt Zinselmeier
@MZinselmeier
Followers
299
Following
2K
Media
88
Statuses
3K
CRISPR-Cas applications in plants. Go Hawks.
Mountain View, CA
Joined September 2011
Massive thanks to @Armandomics for all the day to day work in the lab. And of course @Smanski_Lab for the guidance and lessons in perseverance. Congrats to the entire team!
0
0
1
Excited to share our work on Programmable Transcriptional Activators (PTAs) for plants! We started by screening a library of activation domains in monocots&dicots, culminating in using these PTAs to activate enhancers in protoplasts.
onlinelibrary.wiley.com
Click on the article title to read more.
1
8
13
We did not set out to develop new #SynBio tools for plants, but when the existing tools weren't cutting it (or more specifically weren't expressing it), postdoc Armando Casas-Mollano decided we needed improved CRISPRa for plants. [1/2] https://t.co/UW105fBzO7
academic.oup.com
Abstract. CRISPR/Cas-based transcriptional activators have been developed to induce gene expression in eukaryotic and prokaryotic organisms. The main advan
3
31
124
Excited this pre-print is finally up! Big kudos to Ryan for all the hard work. Lots of conversation at Minnesota, to the final experiments at Berkeley. Who would’ve thought messing with Wuschel could be so fun?
biorxiv.org
Tissue culture methods which serve as the standard to regenerate modified plants are challenging and have limited the capacity to engineer new accessions. To improve upon these techniques, genome...
0
1
4
Roots are hard but this is cool. Massive in field root phenotyping->GWAS/selection scans->gene candidates->transgenic validation in a single paper! Seven years of work (2015-2022) and tens of thousands of dug and imaged roots. Respect. (h/t @MZinselmeier) https://t.co/n1pjz4g39o
2
37
137
Deep learning based genomic prediction methods can start outperforming conventional GP once you get into the thousands of samples. Tested using data from 1,404 maize lines evaluated in five locations, plus wheat and tomato datasets (h/t @MZinselmeier): https://t.co/LjIwfnlOGk
0
11
50
Optimized dCas9 Transcription Activators for Plants https://t.co/zm77P6G5bj
#biorxiv_plants
0
12
26
Our review paper on CRISPR-Cas activators is finally out in @CRISPRjournal. Many thanks to all authors @MZinselmeier, Samuel E. Erickson and @Smanski_Lab for their great work.
0
2
8
I’ve had the privilege of meeting Karl and I'm deeply sorry for the loss in his family. Minnesota has lost 79 of our grandparents, brothers, parents and loved ones to this virus. Each one is heartbreaking. We need to keep working to contain this–it will save lives. #StayHomeMN
The NBA family mourns the passing of Jacqueline Cruz, loving mother to Karl-Anthony Towns. Jacqueline was beloved around the NBA and a great source of strength and inspiration for her family. We extend our deepest condolences to the Towns family during this difficult time.
25
35
543
During this pandemic I’d like to remind you all that Ludacris once absolutely murdered the children’s book Llama Llama Red Pajama
1
0
3
WE CAN BEAT THIS, BUT THIS IS SERIOUS AND WE NEED TO TAKE EVERY PRECAUTIONS. https://t.co/zxMqVB9AWk via @YouTube
1K
5K
32K
“Since this disease is caused by a new virus, people do not have immunity to it and a vaccine may be many months away. Doctors and scientists are working on estimating the mortality rate of COVID-19, but at present it is thought to be higher than that of most strains of the flu.”
0
0
1
COVID-19: 3995 deaths / 113579 cases worldwide = ~3.5% death rate Flu: 468500 deaths / 1000000000 cases worldwide = ~0.05% death rate https://t.co/t3wAA5sOil
So last year 37,000 Americans died from the common Flu. It averages between 27,000 and 70,000 per year. Nothing is shut down, life & the economy go on. At this moment there are 546 confirmed cases of CoronaVirus, with 22 deaths. Think about that!
1
3
9
Upon further reading: @WeAreSinclair can you explain why streaming platforms are dropping regional Fox Sports networks after you acquired them from Disney?
0
0
0
I will be canceling my subscription on Feb 29 and switching to @hulu for the same reason I canceled @Sling and switched to @YouTubeTV months ago. This is so frustrating as a consumer. I now expect Hulu to conveniently drop local sports coverage in 6-12 months time
We purchase rights from Sinclair to distribute content to you. Despite our best efforts, we’ve been unable to reach an agreement with Sinclair. As a result, we will no longer offer FOX Regional Sports Networks, including YES Network, beginning February 29th.
3
0
4
Here is a really cool application of genetic engineering - GM bacteria that normally live in the gut of honeybees engineered to express genes that can kill off the Varroa mite Engineered symbionts activate honey bee immunity and limit pathogens | Science
science.org
Engineered gut bacteria induce immune responses to control honey bee gene expression and protect bees against pathogens and parasites.
0
0
2
Just a reminder for when her “health” show comes out on @netflix
1
0
5
'What's the harm in giving Gwyneth Paltrow a health show on @Netflix?' This morning I put two of my children on the school bus. The third is a box of ashes. Health information should come from experts, not celebrities. Stop giving them platforms. 1/5 https://t.co/wHF1iXHLuC
36
789
2K