RT @UofTDRO: Last chance to register for the Clinical & Experimental Radiobiology Course, offered in a hybrid format! Don't miss this oppor….

RT @UofTDRO: Want to take your expertise in #RadiationOncology to the next level? Don’t miss the chance to learn from our internationally r….

RT @LupoCiyuCy: Time to repost this. We are looking for a for a future colleague to join our comprehensive cancer research institute at Pri….

RT @bradwouters: A big thanks to Therese Christiansen and the @OakvilleBlades for raising over $17K for Breast Cancer Research @pmcancercen….

RT @PMResearch_UHN: Curbing cancer cells’ metabolism 🧫. A study led by Dr.@MKoritzinsky @UHN found that an enzyme, ADO, is critical to keep….

and wonderful collaboration with the labs of @KislingerThomas, @LabMcgaha, @bradwouters, @dalessandrolab and Courtney Jones. Thanks to funders: @tfri_research @STARS21atUT @thePMCF. @AndreaPyo_ @HeliaMoha @LucieMalbeteau @PMResearch_UHN @teamTME_UHN.

So: ADO is key to protect the redox homeostasis of cancer cells and may represent a novel therapeutic cancer target. Tour de force by the formidable @sandyserena___ #ScienceAdvancesResearch.

Our study demonstrates that the metabolic role of ADO in clearing cysteamine is important for cancer cells. Loss of ADO led to polyamine enrichment, which caused upregulation of PRODH, stimulating proline catabolism and mitochondrial activity. This in turn led to toxic ROS levels

The ADO knockout mouse taught us that ADO plays a role in embryonic development but is dispensable in adult murine tissues – at least in the absence of stress. In contrast, ADO is needed in cancer cells to support their proliferation, survival and growth as xenografts. Why?!.

ADO (cysteamine dioxygenase) is a unique enzyme whose substrates include both proteins and metabolites! We were curious about the role of ADO in cancer and normal cells. Excited to share our paper published today:

RT @teamTME_UHN: See the latest paper from Team TME - a great team effort! Using specimens from pimonidazole-labelled prostate cancer tumou….

All are welcome to this 1-week intensive course in Clinical Radiobiology, offered in a hybrid format!.

Seeking motivated postdoc to solve mysteries around how cancer cells secrete proteins in the hypoxic tumor microenvironment. Apply here:

RT @DKirschMDPhD: The EBRT program @RadMedPM @pmcancercentre @UHN is seeking a medical physicist to join our amazing team. We are installin….

All are welcome to our 1-week intensive radiobiology course in hybrid format. See you in April!.

With focus on changes over time and dependency on oxygen concentration. @sandyserena___ @AndreaPyo_.

Wonder how hypoxia changes processes like protein folding and stability, mRNA translation, transcription, epigenetic modification and metabolism to regulate nasty phenotypes in the tumour microenvironment? Check out our review out today!

Congratulations to the amazing Dr. Sandy Lee! It’s been a privilege to be part of your journey. Wonderful celebration today with Wouters & Koritzinsky lab members. 3 papers coming soon - stay tuned!.⁦@sandyserena___⁩

@aguilera_md @AmyWisdom8 @pipcosper @CGlideHurst @StevenLin_MDPhD @IBCradiation @denkolab1 @RadOncDoc_Gee @theabzlab @RRS_RadRes @ACKoongMDPhD @BrianMarples @a_dalpra @DKirschMDPhD.

Great for introduction, great for refresher, all are welcome!.@HenningWillers @TaniguchiMD @JulieSchwarz14 @KevinBennewith @DrMLChua @Qle_stanford @DrShirinAEnger @HSkinnerMDPhD @kkbGoBlue @sueyom @costas_koumenis @carmenbergom @ca_chung @simonpowell213 @JanPOSchuemann.