Dan Landau
@landau_lab
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Somatic evolution, cancer genomics, epigenomics (Weill Cornell/New York Genome Center). Hemato-oncologist (NYP). Discl.: https://t.co/7TBNcbcVCP
New York, USA
Joined August 2015
PATH (phylogenetic analysis of trait heritability) is out @NatureGenet! Excited about tackling the fundamentals of somatic evolution: *measuring cell state heritability *a quantitative definition for cell plasticity (1-heritability) *cell-state transition dynamics 👀🧵👇
Excited to share "Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution", from an amazing collaboration with @landau_lab @ar_davino @TamaraPrietoF @hara_toshiro @MarioSuva! A tweetorial, or Xplanation ... https://t.co/i9aYCTIuO8
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Thrilled to be a co-organizer (w/ @sidichen, #CathBollard, #HongboChi) of the first CSHL meeting on Immune Engineering & Cellular Immunotherapy, which kicks off this evening. Looking forward to a great meeting — and please come introduce yourself if you're attending! #immeng25
meetings.cshl.edu
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Looking forward to delivering lecture at the Annual Congress of #LiquidBiopsy #ISLB25 @isliquidbiopsy in #Orlando #Florida: Glad to share the stage with @JTrentMDPhD @aadel_chaudhuri @EdgardoSantosMD and other colleagues! https://t.co/pwMqivpDu5
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New in Nature Reviews Genetics: my Review on how advanced genomic technologies are redefining cellular reprogramming: mapping trajectories, dissecting chromatin dynamics, + lineage tracing & synthetic circuits to push the boundaries of cell identity. https://t.co/8NBM5ohxkJ
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New preprint! We know cancer cells with somatic mutations are selected to evade the immune system. With @imartincorena Peter Campbell @ZJL1435957 @QuotientTx, we asked if immune cells with somatic mutations are also selected to fight cancer. https://t.co/2CWjTgZ3nY 1/5
biorxiv.org
Cancer cells evolve to increase fitness and evade the immune system, but it is not clear if tumor infiltrating lymphocytes (TILs) undergo selection for somatic mutations that augment anti-cancer...
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Congrats to my postdoc, Aya Ludin Tal, on her Cell paper. Her work using live imaging in zebrafish identifies CRATERS on the surface of melanoma - immune hubs for T cells. CRATERS in human melanoma are the best predictors of immunotherapy success. https://t.co/TWaWJUZdTp
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Dr. Ross Levine (@rosslevinemd), Senior Vice President of Translational Research at MSK, has been named MSK's new Chief Scientific Officer (CSO). Dr. Levine will be responsible for setting and leading strategy for basic and translational research, including programs, centers,
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BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has
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Congrats to our lab's recent MD-PhD grad Rachel Yan (@rachyan_ ) on the beautiful cover art accompanying her MultiPerturb-seq work!
The October issue is live https://t.co/uEGWhO2B55 The cover shows perturbations that convert stem-like, atypical teratoid rhabdoid tumor (AT/RT) cells into a more differentiated, neuron-like state https://t.co/KcjY604fNf
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Standing on the shoulders of giants! @imartincorena @jyoti_nangalia Phil Jones, Peter Campbell @ChrisAWalsh1 and many more
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Shout out to the incredible Charles Gawad for pioneering PTA and to our friends at @bioskryb & @UltimaGenomics for believing in this vision. Gratitude also to our funders @TheMarkFdn @theNCI @cegs_ica @SMaHTnetwork
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Towards a future where we can track the evolution of the trillions of cells in our body 🥳 Huge kudos to Tamara Preito, @dennisjyuan @JohnZinno @raimondi_ivan & the whole team. Gratitude to our many collaborators including Julian Abrams Seishi Ogawa and many more.
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Highlights: - Immune cell clonal expansion & migration - Mutational signatures change through life - Driver acquisition, growth dynamics and impact on phenotype - CNVs in normal esophagus - Selection of chr9q cnLOH with convergent acquisition multiple times through life
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Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. https://t.co/pciw5yME0x
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A fascinating study shows that the longest lived-rodent evolved a cGAS variant to boosts DNA repair while dampening inflammation. Uncoupling genome surveillance from inflammation may be the secret to longevity #aging #inflammation
science.org
Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that...
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A singing telegram, but for reminding collaborators to edit the grant we’re supposed to be working on
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Out today the last piece of work that Maria Guillamot did in our lab in a collaboration with @AWeinstock and @DrShrutiNaik (who lead the study) showing type I interferon (IFN)-mediated activation of hematopoietic stem/progenitor cells resulting in profound changes to systemic
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