Daniel Wrapp
@LabWrapp
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Structural biologist specializing in host-pathogen interactions
Joined June 2020
Can we leverage recent developments in machine-learning & protein design to tackle previously intractable challenges? The answer is yes and we show it in this study led by the one and only @Dr_MattMcCallum
@HHMINEWS
@UWBiochemistry 1/9 https://t.co/rOMv0cBuyf
biorxiv.org
In the absence of effective vaccines, human-infecting members of the Herpesvirus family cause considerable morbidity and mortality worldwide. Herpesvirus infection relies on receptor engagement by a...
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Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science!
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My group at @ISTAustria is recruiting a lab manager/research technician to join when we start in July! If you're passionate about science and thrive in a dynamic environment, apply here: https://t.co/7WIRVGXR4V
#ResearchJobs #LabManagement #ScienceCareers
ista.ac.at
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Excited to share the pre-print describing our efforts to stabilize the HCMV gB ectodomain in a prefusion-like conformation. We and others have now routinely stabilized class I viral fusion proteins, but class III viral fusogens have been more difficult.
Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation https://t.co/gko1JISVVi
#bioRxiv
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My Department (Biochemistry, Microbiology and Bioinformatics @ Université Laval) has 2!! tenure track positions open: one in viral ecology and one in microbial functional genomics. Awesome place to start your new lab and wonderful colleagues! 😉 Get in touch if interested. 🦠🤓
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Well deserved!! Congratulations @McLellan_Lab !
The winner of the 2023 NAS Award in Molecular Biology is Jason S. McLellan of @TexasScience! He is being honored for pioneering work in the molecular and structural biology of viral surface proteins. Learn more: https://t.co/S3djB0FGtp
#NASaward #MolecularBiology
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Very happy to share the peer-reviewed version of our manuscript, available now ahead of print with open access at @JVirology ! Wonderful collaborative effort with my colleagues here @TheDHVI
https://t.co/qVs1dzM5Lx
journals.asm.org
Recent estimates have placed the number of new human immunodeficiency virus type 1 (HIV-1) infections at approximately 1.5 million per year, emphasizing the ongoing and urgent need for an effective...
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Our preprint has been released on bioRxiv! Details a new stabilization strategy that should be a useful tool for researchers trying to produce tricky HIV Env proteins. Great collaborative effort from @DHVI_Struc_Bio @lab_haynes @TheDHVI
https://t.co/cG1DSgxRq8
biorxiv.org
The envelope glycoprotein (Env) is the main focus of HIV-1 vaccine development due to its critical role in viral entry. Despite advances in protein engineering, many Env proteins remain recalcitrant...
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Delighted to have my 1st first-author paper @CellReports! High-res site Ø and V complexes. Plus, now includes structural mapping of two non-canonical sites at the trimer interface, which are preF targets but elicit low neut mAbs. Thanks to all involved!
cell.com
Human metapneumovirus (hMPV) infections can lead to severe outcomes for the elderly. Rush et al. use engineered hMPV fusion proteins to isolate and characterize antibodies generated from natural...
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Come work with us! We are hiring a lab manager to support our team investigating a broad spectrum of emerging and re-emerging viruses and developing vaccines & therapeutics! Please RT and pass the word as widely as possible.
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Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin
cell.com
Bordetella adenylate cyclase toxin (ACT) targets leukocytes via surface-expressed integrin αMβ2. Goldsmith et al. use cryoelectron microscopy to reveal the structural basis for this non-canonical...
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The Gobeil Lab is now officially online! Check it out: https://t.co/rH2GmH4ISt (and we are recruiting students - If interested in structural biology, viral evolution and protein engineering don't hesitate to reach out!)
gobeil-lab.github.io
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Received an email from Rino Rappuoli this morning informing me, @BarneyGrahamMD and Peter Kwong of the positive phase III data for the RSV prefusion F vaccine results in older adults. It's been almost 10 years since we designed the first prefusion RSV F antigen, DS-Cav1. Amazing!
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Our 1st “official” position is now posted!!! Interested in coronaviruses and other pandemic threats, have previous lab tech experience, and want to join a super cool viral immunology lab at @HarvardChanSPH? APPLY to be our RESEARCH ASSISTANT III:
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Congrats to Dr Akaash Mishra @AkaashMishra88 on his PhD thesis defense! Beautiful work on the structure and function of CCHFV glycoproteins and protective human antibodies. Next stop, Merck!
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Very pleased to see this come out alongside the beautiful, closely related work from Claudio Ciferri's group https://t.co/C9TuvZa3EO
science.org
Cryo-EM reveals the structures of the HCMV Pentamer complex bound to cellular receptors NRP2 and THBD or neutralizing antibodies.
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The peer-reviewed version of our manuscript describing the structure of NRP2-bound HCMV Pentamer is now available @ScienceAdvances! https://t.co/Xnj711ArpK
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Efficient discovery of SARS-CoV-2-neutralizing antibodies via B cell receptor sequencing and ligand blocking https://t.co/hWNXnppf33
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We are honoring @BarneyGrahamMD with the 2022 John J. Carty Award for the Advancement of Science for pioneering new strategies in vaccine design using nanoparticle and mRNA technologies. Congratulations! Read more: https://t.co/dT2S1XV9c5
#NASaward #biotechnology
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Great piece on RSV vaccine and antibody development. We should soon have more interventions available to fight this virus!
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