Congratulations to Kerim Anlaş, @nicola_gritti & @LabTrivedi @embl @the_prbb for the work on early autonomous patterning of the anteroposterior axis in gastruloids @Dev_journal. https://t.co/EBlkoms9mv

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🔎@viktri08 lab (@EMBLBarcelona) and @jvveenvliet team (@mpicbg) have independently found that glycolysis plays a much more active role in embryonic development than previously thought, revealing glycolysis’s dual role: metabolic and instructive. Moreℹ️👇 https://t.co/Hgz6tfVTtl

We’re excited to share amazing science our microscopes are enabling🔬 From #3Dimaging to developmental and cancer biology, spatial-omics and more!🧬🧠 Follow us for cutting-edge discoveries at @embl @the_prbb and discover how #mesoscopic imaging can support your research

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We’re looking for PhD students to join the lab! 🧫🧑‍🔬 Curious about how metabolic processes shape patterning and morphogenesis? Enthusiastic about stem cell models for human development? - Then apply through the VBC PhD program! https://t.co/peCAFrZVem ‼️Deadline: April 15‼️

Amidst these troubling times, I have some positive personal news to share: I will be joining @IMBA_Vienna as a new group leader this fall! 🎉 I am excited for fun projects, surprising discoveries, and great discussions within the fantastic science community @viennabiocenter.

EMBL International PhD Programme - summer recruitment 2025! 👀 Research groups across EMBL are recruiting now! https://t.co/EvhDhhrV5l Don’t miss this opportunity to receive dedicated mentoring while doing interdisciplinary research. 👩‍🔬

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If you want more details you can read the paper here:

Hence, we suggest that not only cell-cell rearrangements, but also cell-cell communication are likely to work synergistically and biochemical and mechanical processes evolve under a common morphogenetic timescale in the system.

But is that all? what about the difference in the timing of symmetry breaking depending on the initial fraction of T+ cells? Our proportion experiments can be explained assuming that pluripotent stem cells (A) inhibit mesoderm differentiation of Bra+ cells (B).

Could there be mechanical differences between Bra+ and Bra- tissues leading to cell sorting? The answer was yes! By combining fusion experiments and nanoindentation we found Bra+ tissues to have a higher surface tension than Bra- tissues. 🧐

Those aggregates as well as gastruloids followed the same progression: At 24h, Nanog+ (magenta) and Bra+ (green) were found in a salt and pepper configuration, while around 48h islands of T- cells (Aldh1a2, Gata6 in yellow) formed on the outside, surrounding a core of Bra+ cells

Heterogeneity on the initial levels of T expression is known to influence gastruloid formation. We decided to form aggregates with controlled proportions of T+ and T- cells and found that increasing the initial T+ cell population speeds up polarization and elongation.

This has been a collaborative work between our lab @EMBLBarcelona @EMBL and @jgojalvo lab @UPFbiomed @UPFBarcelona. We also like to thank the amazing environment and facilities in @the_prbb!

We are excited to share the latest contribution from the lab! We found that cells in gastruloids communicate to each other in order to control the timing of gastruloid symmetry breaking.

@MafaldaFigDias @PhilippeMortie3 @c_n_george @CRGenomica @HMar_research @MartonaAlvarez @sarah_warkentin @IBE_Barcelona @ISGLOBALorg @UPFbiomed @UPFBarcelona @CSICCat 🔬 @AMartinezArias & @viktri08 engage in an in-depth debate about our knowledge of cells. And we are accompanied by the residents of the Park to list the qualities of good supervision. ▶️ https://t.co/ibWO9mXAph #ScienceWithAView

Thanks to @Dev_journal for "The people behind the papers" article as well! https://t.co/Ww4SxNi0IW

Did you know that we all start life as a symmetric ball of cells? Later, a process called gastrulation breaks this symmetry and sets up our body plan. @EMBLBarcelona researchers have revealed how cells can behave autonomously during this process. https://t.co/uODGrw8Ht7