Manuel Irimia
@mirimiam
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ICREA Evolutionary Biologist working on transcriptomics of development and evolution at @UPFbiomed and @CRGenomica. Coordinator of the @EvoMG_Bcn Joint Program.
Barcelona, Spain
Joined April 2011
New release of annotations in @VastDB (v11). With this release we cover all the previous studies experimentally investigating the functions of AS events we were aware of, with a total of 5542 entries (EventID-PubmedID pairs). @CRGenomica
We have released a new batch of functional annotations (v11): 600 entries from previous publications investigating the function of AS events. This makes a total of 3637 entries directly from publications, 397 from CRISPR screens and 1511 from experimentally validated ELMs.
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🚨Great podcast on our most recent work using @NotebookLM on the role of microexon in DAAM1 in memory formation! 🧠🐁🔬🧫 @mirimiam @maradierssen @CRGenomica @MSCActions @Mariecurie_alum @ERC_Research
https://t.co/xaZ2q6AGfU
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Thrilled to share my 1st PhD paper, exploring the role of a DAAM1 microexon in memory formation and learning! 🧠🐭💻🔬 #PhD #PhDthesis Finally published in @NatureComms: https://t.co/npc32rDbu0 . With @mirimiam, @maradierssen, @Blencowe_Lab, @CRGenomica, @icerca Details below:
nature.com
Nature Communications - Actin is crucial for nervous system function yet the role of microexons in its modulation is unclear. Here, the authors show that a microexon in DAAM1 has a role in actin...
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Si eres estudiante grado/máster y te apasiona la genómica aplicada a salud, aplica a la #JAE Intro ICU de @elenagomezdiaz / @mirimiam @GenomaHubCSIC 💡Descubre con el análisis de long-read single cell RNA-seq cómo el parásito de la malaria usa splicing alternativo para sobrevivir
📢Ya puedes solicitar una de las🔟becas ofertadas por @GenomaHubCSIC dentro de la convocatoria #JAE Intro ICU 2025 🗓️Dealine: 16 de abril Más información ➡️
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The job call is officially open. If you're interested, please apply through this link ASAP! 😃 https://t.co/D10eM64ivF Please RT! 🙏
🚨🚨🚨 If you're a bioinformatician who loves: 🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing 🚀 Collaborating and travelling Apply to work with us at the spectacular @BIMSB_MDC in Berlin + @UPFbiomed-@CRGenomica in Barcelona. Qs: https://t.co/ZikhH1zEGM Please RT!🙏
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This sounds like a dream!! Barcelona and Berlin with amazing scientists and great people. Having worked with both groups I would highly highly (yes twice :) recommend it.
The job call is officially open. If you're interested, please apply through this link ASAP! 😃 https://t.co/D10eM64ivF Please RT! 🙏
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The job call is officially open. If you're interested, please apply through this link ASAP! 😃 https://t.co/D10eM64ivF Please RT! 🙏
🚨🚨🚨 If you're a bioinformatician who loves: 🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing 🚀 Collaborating and travelling Apply to work with us at the spectacular @BIMSB_MDC in Berlin + @UPFbiomed-@CRGenomica in Barcelona. Qs: https://t.co/ZikhH1zEGM Please RT!🙏
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🧬 Want to implement Open-ST in your lab? We've published a detailed guide that takes you from tissue sections to 3D molecular maps https://t.co/IrpTFnnoe9
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Pot Darwin ajudar-nos a entendre el càncer, la infertilitat o les al·lèrgies? El primer programa de genòmica mèdica evolutiva del món neix a Barcelona @CRGenomica @UPFBarcelona @IBE_Barcelona
ara.cat
El primer programa de genòmica mèdica evolutiva del món neix a Barcelona
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The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. https://t.co/i05me2SXI4 1/n
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Monod Conference "Origin of metazoans": fossils, genomes, cell biology, gene regulation, development, and more. Join us in Roscoff for an exceptional speaker line-up and stunning venue! 🗓️Abstract deadline: March 4. Register and share! https://t.co/Hs5xRK6NsV
insb.cnrs.fr
Roscoff (Bretagne), France, June 16-20, 2025Deadline for application: March 4, 2025
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One week left to apply! Join our team to explore the diversity chromatin regulation mechanisms across eukaryotes or to study the genomic basis of cell type microevolution in cnidarians (as part of our #ERCCoG project).
We have two open PhD positions in my group at @CRGenomica. We are seeking candidates with a background in comp. and/or molecular biology, and with a broad interest in evolution, gene regulation, and comparative genomics. 🗓️Apply before Jan 12 here:
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📢 We're hiring! We are looking for two early career candidates to join #MELISupf as Junior Group Leaders in Computational Biology, and in Quantitative Biology More information and application links: https://t.co/ZuRdQ2IKXF and https://t.co/suPA3xFlGg Deadline: 28/01/25
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🚨🚨🚨 If you're a bioinformatician who loves: 🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing 🚀 Collaborating and travelling Apply to work with us at the spectacular @BIMSB_MDC in Berlin + @UPFbiomed-@CRGenomica in Barcelona. Qs: https://t.co/ZikhH1zEGM Please RT!🙏
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I can’t think of a better way to close the year—my thesis article has been published! It’s the result of years of learning and perseverance, and I’m grateful for all the support along the way. Read it here: [ https://t.co/z66sw95Cq6]
#Research #Thesis
🐟Our new paper "Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish" is out in @eLife🐟 A nearly 10-year tour-de-force by Laura Lopez-Blanch and many others in the lab @CRGenomica & @UPFbiomed
https://t.co/M8rt8jyWaI Thread👇
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✅Last paper of 2️⃣0️⃣2️⃣4️⃣, a great colaboration with @mirimiam of @CRGenomica where the role of micoexons in VAV2 and other genes have been identified and characterized. Thank you for letting us be part of this work. @ciccancer
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@sepeap94 @FedeMantica @doctor_calvo @tahnee_mac @jordifernalbert @XRBustelo @dePolaviejaLab @ERC_Research And here’s Laura’s handle @lau_lbl 🤦♂️🤦♂️🤦♂️ congrats!! 🤗
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Thanks and congrats to Laura, @sepeap94, @FedeMantica, @doctor_calvo, Jon, Beth, @tahnee_mac, Mireia, Paco, @jordifernalbert, Myriam, @XRBustelo, @dePolaviejaLab and @ERC_Research
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This story is published back-to-back with @summerbthyme, who deleted 45 microexons (only two in common with us) and assessed larval brain activity, morphology and behavior. They also found that most individual mutants had minimal or no phenotypes: https://t.co/y0l17VMesh. 9/9
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Finally, transcriptomic comparisons between mutant larvae and their wild type siblings suggest that coordinated misregulation of specific neural-related pathways may provide functional compensations at the molecular level. 8/9
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We also implemented a new method for primary neuronal culture and neurite length quantification from FACSorted HuC+ neurons. With this method we also identified microexons whose deletion leads to decreased (vav2) or increased (evi5b, itsn1) neurite lengths. 7/9
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