Cheng Fly Lab
@LabFly
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We are interested in how nutrient, and metabolism affects stem cells and tumours
Melbourne, Australia
Joined August 2018
RT @BenjaminHogan13: Come and join us! We are looking for a bioinformatician to join the lab. Work with single cell, multiome and spatial d….
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Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
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RT @AlexGouldLab: Our latest from @TheCrick ….Sebastian Sorge led on this amazing new chemically defined (holidic) diet for fast larval gro….
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It was a privilege to appear on @RRR to talk about our research and discuss what patients should know about cancer cachexia - a metabolic wasting disease affecting cancer patient outcomes. Grateful to our consumer Sudhir Sakhuja and my clinical collaborator @HyunKoMD.
"Cancer cachexia" affects 30% of cancer patients - 80% for advanced cancers - and yet few have heard of the term. Assoc Prof Louise Cheng (@LabFly), @HyunKoMD and cancer survivor Sudhir, have explained this muscle wasting condition to @3RRRFM. Listen:
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RT @HongyanWang9: Paper is out! Astrocytes control quiescent NSC reactivation via GPCR signaling–mediated F-actin remodeling | Sci Adv http….
science.org
GPCR-Gaq signaling from astrocytes controls actin cytoskeleton to promote neural stem cell reactivation in Drosophila.
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RT @CreteFlyneuro: We are excited to announce the next Workshop on Neural Circuits & Behavior of Drosophila that will be held at the Orthod….
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RT @FlyJedi: Missing our @FlyJedi meetings? The #JEDI are back for great #Drosophila science! Follow us for more news and dates! #thereturn….
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RT @KatMitchell_Sci: Very excited to share our #preprint in @biorxivpreprint in which we found that the transcription factors of JNK and Hi….
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As the Drosophila OL shares a similar mode of division with mammalian neurogenesis, understanding when and how these progenitors cease proliferation during development can have important implications for mammalian brain size determination and regulation of its overall function.
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The termination of medulla NBs during early pupal development is determined by the exhaustion of the NE stem cell pool made during larval development. Hence, altering NE-NB transition during larval neurogenesis disrupts the timely termination of medulla NBs.
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In the Drosophila optic lobes, medulla NBs derived from the neuroepithelium give rise to neurons and glia cells of the medulla cortex. In this work, we demonstrate medulla NBs terminate via a fail safe mechanism through cell death, differentiation and gliogenesis.
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A big thank you to the expert reviewers, and a fast and efficient process @ReviewCommons @eLife.
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Happy to share the latest work from the lab, led by our PhD student Khanh Nguyen @khanh_ng97 .@eLife.
elifesciences.org
The termination of medulla neuroblasts is specified by the depletion of the neuroepithelium and mediated by apoptosis, differentiation, and gliogenic switch.
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RT @pr_jusuf: @LabFly @VeenKellie @UniMelb Amazing work by @VeenKellie and great collaboration with @theo_brainc_lab and @AaronKrylov .
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We thank the reviewers @ReviewCommons for expert reviews, fast turn-around and great suggestions.
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As muscle ECM proteins are mostly fat body-derived, the retention of ECM proteins in the fat body causes a reduction in muscle ECM, which results in muscle detachment during cancer cachexia.
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Here we show that TGF-β and insulin signalling converge in the fat body to control ECM secretion via short gastrulation (sog), a TGF-β antagonist.
embopress.org
image image During cancer cachexia, insulin and TGF‐β signalling converge in the fat body via Sog to hinder ECM secretion, which in turn affects muscle integrity. Eye tumour models employing RasV12...
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Paper No.2 led by Daniel Bakopoulos was a part of a great collaboration with @DrLizChristie @PeterMacRes and @stramerlab
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Kellie’s paper on dedifferentiation in the fly CNS was published earlier this year in
embopress.org
image image Dedifferentiated neural stem cells show aberrant expression of temporal transcription factors, resulting in incorrect types of neurons produced and impaired terminal differentiation. This...
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