Jain Lab
@KruppelLab
Followers
120
Following
4
Media
5
Statuses
33
Mukesh Jain's Lab - now at @BrownMedicine Studying KLFs in aging, metabolism, immunity, cardiovascular disease, & chromatin biology
Joined November 2020
RT @davidr_sweet: Excited to share the latest work from the @KruppelLab exploring our favorite transcription factors in maintaining endothe….
0
5
0
@liyan_fan14 @davidr_sweet @EricaKFan @roshan_818 @vineshv @saptarsi_haldar @cwrumstp @CWRUSOM continuing to generate well-equipped and brilliant trainees!.
0
0
0
The best work opens up exciting new questions and this does just that! Great job, @liyan_fan14 and all co-authors involved including @davidr_sweet @EricaKFan @roshan_818 @vineshv and @saptarsi_haldar . #Metabolism #Transcription #doubledocs #physicianscientist . 7/7.
1
0
2
Could targeting KLF15-PPARd interactions impact systemic metabolic disease? Might this interaction play a role in the known functions of KLF15 and PPAR, individually, in exercise physiology? . 6/n.
1
0
0
Liyan's previous work demonstrated that loss of KLF15 in skeletal muscle leads to improper lipid handling by muscle, contributing to systemic lipid deposition (eg fatty liver disease). See - 5/n.
1
0
0
This may explain why mice deficient in KLF15 or PPARd have remarkably similar metabolic phenotypes. Therapeutically, proper targeting of PPARd signaling through a specific agonist is diminished with loss of KLF15. 4/n.
1
0
0
Interestingly, loss of KLF15 in skeletal muscle renders PPARd unable to properly bind to its target sites, greatly impacting the metabolic genes that are transcribed. 3/n.
1
0
0
In this work, she describes a role of the transcription factor KLF15 in modulating specific metabolic transcriptional programs through its recruitment of PPARd (a known powerhouse of metabolism). 2/n.
1
0
0
As promised, here is more exciting news from our group! . @liyan_fan14 is at it again, continuing to dissect molecular control of skeletal muscle metabolism in her recently accepted manuscript in @jbiolchem . 1/n.
jbc.org
Skeletal muscle dynamically regulates systemic nutrient homeostasis through transcriptional adaptations to physiological cues. In response to changes in the metabolic environment (e.g., alterations...
1
3
21
RT @liyan_fan14: Saw this mug in my cabinet this morning and was reminded of all the good fortune of my PhD with an oral presentation at @t….
0
5
0
Thanks for stopping by and celebrating with us! We have a couple projects wrapping up and will hopefully have even more exciting news soon - stay tuned! .#physicianscientist #doubledocs #MedTwitter #AcademicTwitter @CWRUSOM @UH_RE_Institute @UHhospitals .8/8.
0
0
5
We are excited to share that new work in metabolic transcription by @liyan_fan14 was just accepted for publication! You'll have to keep an eye out on your timelines for the official announcement in the near future 🤫 7/n.
1
0
1
Our fearless leader, Mukesh, has recently been named the Dean of Medicine and Biological Sciences at @BrownMedicine where he will continue to advance the mission of educating future physicians, scientists, and physician-scientists..6/n
1
1
7
Have you ever wondered how transcription factors may have evolved in different cell types to enhance intercellular physiology? @davidr_sweet has and wrote about it in a perspective written in @FrontCVMedicine 5/n
1
0
3
This duo (along with many others) also demonstrated a role for infiltrating and resident myeloid cells in a model of Takotsubo cardiomyopathy, published in @JCI_insight 4/n
1
0
3
We continued to explore the role of immune cells in the biology of non-ischemic heart failure through the hard work of Xinmiao Tang and Xudong Liao, published in @jclinicalinvest this fall! 3/n
1
0
2
Two of our fantastic @cwrumstp students, @liyan_fan14 and @davidr_sweet defended their dissertations in the spring. They both will be applying to internal medicine residencies next year, so keep an eye out for them! You'll want this dynamic duo at your institutions! 2/n
1
1
7
It's been awhile since our group has tweeted and we have a ton to celebrate and share! Buckle up, because here comes a thread praising some wonderful science and even more wonderful people! 1/n.
1
1
7
RT @jclinicalinvest: .@liyan_fan14 @KruppelLab @CWRUSOM: Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeosta….
0
3
0
And in great company including @saptarsi_haldar @SwayVidDeet @HongShi903003 Nelson Hsieh, Lalitha Nayak, Xudong Liao and many others! Fantastic work!. @UH_RE_Institute @cwrumstp @A_P_S_A @jclinicalinvest.
Finally got to put my paper up on the CVRI publication wall - been dreaming of this day since I first rotated in the @KruppelLab 🥳 A huge thank you to the team of people who helped make this happen, including all those who came before me who set the foundation for this work.
2
1
11