 
            
              Kieran Docherty
            
            @Kieranfdocherty
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              Clinical Senior Lecturer in Heart Failure and Clinical Trials @UoGHeartFailure Honorary Consultant Cardiologist, Glasgow Royal Infirmary
              
              Glasgow
            
            
              
              Joined October 2009
            
            
           Delighted to present these data today at #ESCCongress looking at the potential benefits of the early initiation of disease-modifying therapy in community-based patients with suspected HF Simultaneous publication at @ESC_Journals EHJ  https://t.co/1mjvXC3wIZ 
          
          
                
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             Elevated IL-6 & hs-CRP levels = higher risk of worsening HF or #cvDeath in #HFrEF patients, based on DAPA-HF study. ✅ However, #dapagliflozin reduced outcomes regardless of baseline inflammation 📎  https://t.co/AAQtJovnUi 
            #JACCHF #HeartFailure @scottdsolomon
          
          
                
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             📣Can wearable accelerometers predict HF outcomes? Original research with a subgroup of DETERMINE trial patients showed: ⬇️Physical activity assessed by accelerometer🏃🏾♂️ --> ⬇️KCCQ, ⬇️ 6MWD, ⬆️ NT-proBNP #Wearables #HFoutcomes 🔗  https://t.co/Awbd6eIrwa 
          
          
                
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            #PREVENTHF launching Mar '25 New large first-of-its-kind #CKM trial focused on *prevention* of HF n=11,300 pts w T2D, ASCVD, HTN (but w/o HF) Randomization: ASi (baxdrostat) + SGLT2i (dapagliflozin) vs SGLT2i alone PEP: new diagnosis of HF or CV death  https://t.co/GBkU7ER6da 
          
          
                
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             EMPRESS-MI now published. No effect of empagliflozin on ventricular remodelling in patients with LVEF ≤45% following acute MI. However...very few patients had progressive adverse remodelling. The challenge is identifying patients at risk of adverse remodelling in the modern era. 
           EMPRESS-MI: Empagliflozin vs placebo, n=105 w/ LVSD (mean LVEF 34.8%) post-AMI (24wks): ↔️LVESVI, LVEDVI, LVEF, LAVI, LVMI ↔️NT-proBNP, hs-TnI ↗️Hct ↘️urate, weight 🔗  https://t.co/y9H63nVVB0 
              @CarberryJaclyn @Kieranfdocherty
              @markcpetrie20 @ColinBerryMD
              @UoGHeartFailure @UofGSCMH
            
            
                
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             Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in HFmrEF/HFpEF: a Prespecified Analysis of The FINEARTS-HF Trial Now online @CircAHA after presentation at #HFSA2024 Consistent benefit of finerenone regardless of LVEF  https://t.co/Hp8RUBF7PQ 
          
          
            
            ahajournals.org
              BACKGROUND: The effects of treatments for heart failure (HF) may vary among patients according to left ventricular ejection fraction (LVEF). In FINEARTS-HF (Finerenone Trial to Investigate Efficacy...
            
                
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             An age-old hemodynamics debate: pressure vs volume. Pressure-guided RPM are available, but what about volume? 🚨FUTURE-HF2 trial: Out Now in @JCardFail! Safety & feasibility of the FIRE1 implantable IVC sensor from #HFSA2024 🔗  https://t.co/lU3nZjapJ8 
          
          
                
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             Delighted to present these data today from the DETERMINE trials at the #ESCCongress The first evidence of a beneficial effect of a HF therapy on accelerometer-based measures of physical activity. A promising new outcome measure for HF trials. 
           Simultaneous Publication w/ #ESCCongress 2024 from @UoGHeartFailure & @Kieranfdocherty et al: Effect of Dapagliflozin on Accelerometer-Based Measures of Physical Activity in Patients with Heart Failure: An Analysis of the DETERMINE Trials  https://t.co/aB1105OKCs 
              #AHAJournals
            
            
                
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             Simultaneous Publication w/ #ESCCongress 2024 from @UoGHeartFailure & @Kieranfdocherty et al: Effect of Dapagliflozin on Accelerometer-Based Measures of Physical Activity in Patients with Heart Failure: An Analysis of the DETERMINE Trials  https://t.co/aB1105OKCs 
            #AHAJournals
          
          
                
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             As #ESCCongress kicks off, I am proud to share this review article on Digital Tools in Heart Failure, where we tried to cover all aspects of this promising field Open access @LancetDigitalH 😊  https://t.co/43rw3VLTbU 
            @DrJasper1 @Kieranfdocherty @CMichaelGibson @lamcardio
          
          
                
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             New review in #JACCHF by @Kieranfdocherty on the treatment and prevention of HF following AMI. * Review of current evidence and guideline recommendations * Discussion of ongoing research * Proposal to identify highest risk pts to guide tx 🔥Don't miss!!  https://t.co/qUUkVL5axj 
          
          
                
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             Great to see the design paper of our mechanistic remodelling trial of SGLT2i following acute MI published - final study visits in the next few weeks and hopefully results will be ready to present later this year! 
           EMPRESS-MI will assess the effect of the SGLT2 inhibitor empagliflozin on cardiac remodelling in patients with LVSD after an acute MI.  https://t.co/vBcTTchMoQ 
              @CarberryJaclyn @markcpetrie20 @ColinBerryMD @Kieranfdocherty @UoGHeartFailure @UofGSCMH @BHFCoREGlasgow
              #HF #MI #SGLT2i
            
            
                
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             EMPRESS-MI will assess the effect of the SGLT2 inhibitor empagliflozin on cardiac remodelling in patients with LVSD after an acute MI.  https://t.co/vBcTTchMoQ 
            @CarberryJaclyn @markcpetrie20 @ColinBerryMD @Kieranfdocherty @UoGHeartFailure @UofGSCMH @BHFCoREGlasgow
            #HF #MI #SGLT2i
          
          
                
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             Honored, humbled and very excited to be selected as candidate for position of president-elect for the #HFA board elections! To all members, please don’t forget to vote for these fantastic people!  https://t.co/LJrkdSZgSX  Here are my top six priorities....together we can make it 
          
                
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             To become the future of the clinical trials, apply here :  https://t.co/ArvitDllIh 
            #CardioTwitter #Diversity #clinicalresearch
          
          
            
            globalcvctforum.com
              Apply to the Young or Future Trialist Initiative of your choice here !
             [CALL FOR APPLICATION] Join the steering committee of an ongoing major clinical trial as a full member with #CVCT Future Trialists Fellowship ! Deadline extended until February 14th, apply here :  https://t.co/H04HrL2Bi2 
              #clinicaltrials #clinicalresearch #CardioTwitter
            
            
                
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             Sacubitril/valsartan and Alzheimer's disease biomarkers. Great collaboration with @wagnersbrum demonstrating an important drug-test interaction with a commonly used AD blood test (Aβ42/Aβ40). Also reassuring results in other biomarkers of neurodegeneration  https://t.co/UZa40JzL8t 
          
          
            
            jamanetwork.com
              This exploratory analysis of a randomized clinical trial evaluates the effect of neprilysin inhibition on Alzheimer disease blood biomarkers in patients with heart disease.
            
                
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             Fantastic few days at @CVCTForum. Great talks on recent and upcoming trials with some thought provoking discussions and an opportunity to catch up with friends and colleagues. Thanks to @FaiezZANNAD for the opportunity and support through the Young Clinical Trialist Fellowship 
          
                
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             Enroute to Philadelphia for #AHA23 Will be presenting some new data from DAPA-HF on Monday at 10:30AM - Interleukin-6 in Patients With HFrEF and the Effect of Dapagliflozin (Poster Board 2229) 
          
                
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             Subcutaneous furosemide for patients with heart failure. Promising results of 2 phase I trials. Published this week and featured in today's episode of ESC TV Today.  https://t.co/OeMrSzdhg1 
            #furosemide #SQfurosemide
             https://t.co/32MnDG5IyI 
          
          
            
            academic.oup.com
              AbstractAims. Subcutaneous (SC) furosemide has potential advantages over intravenous (IV) furosemide by enabling self-administration or administration by a
            
                
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