Jon Cunningham
@JonWCunningham
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Heart Failure Cardiologist & Investigator, @BrighamWomens @harvardmed @broadinstitute AI to Improve Cardiovascular Clinical Trials & Care
Boston, MA
Joined February 2018
Can AI automate HF adjudication in global clinical trials? Our latest #AHA2024 SimPub @CircHF In the DELIVER trial, our AI model for HF hosp was -Accurate -Generated identical treatment estimate for dapa as human CEC -Extracts evidence of HF Paper: https://t.co/cYslPU1fzP
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📢 Time for one of our most anticipated meetings of the year! Novel Statistical Concepts for HF Drug and Device Development Join us on November 14, 2025 | 8:45 a.m - 12:30 p.m. ET via Zoom Open to all — no HFC membership required Register here: https://t.co/7O7YZP11zE
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🚨 New in @CircAHA : Maternal CVD and pregnancy-related CV complications are rising sharply over 2 decades across >56K pregnancies across @MassGenBrigham. Pregnancy is a critical window for lifelong heart health! 🔗 https://t.co/H6d6FvwRdr
@MGBResearchNews #CardioObstetrics
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📢Personal update! ✨Thrilled to share that I’ll be moving my clinical practice to @BrighamWomens as Director of Women’s Heart Health. So grateful to my many mentors, colleagues & friends 🙏. Excited for this next chapter working to advance women’s 🫀 health! @MGBWomenHeart
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Flu causes major illness and death, but vaccination rates are falling. A large trial found that cardiovascular-focused nudges did not increase vaccination rates. In an accompanying editorial, the authors contextualize the findings. https://t.co/0I1uub4emJ
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🚨 An extraordinary achievement from all the @CTCPR_ researchers at ESC! Our researchers simultaneously published 13 papers across leading journals, showcasing some of the latest breakthroughs in cardiology. These publications include: · 3 in The New England Journal of Medicine
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How can AI enhance Clinical Trials? In latest @hfcollaboratory Heart of the Matter Podcast @coconnormd & panel share ideas on how to use AI to increase value/quality, design, patient selection, other aspects @mpsotka @dranulala @ankeetbhatt
https://t.co/2ZIINvTpqd
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Delighted to have shared the results of ENVAD-HF as late-breaking science at #ESCCongress: 1st prospective RCT of #HeartFailure #GDMT #sacval in #LVADs: -numerically less primary outcome (death, ⬇️ renal fn, hypotn and hyperK) -safe, feasible, well tolerated -improved PROs
ENVAD-HF, a prospective RCT in stable HM3 #LVAD recipients, shows angiotensin–neprilysin inhibition is safe and well-tolerated, paving the way for trials of #HF therapies in this population. https://t.co/NrayztGHvi
#JACCHF #ESCCongress #WCCardio @MajaCikes @scottdsolomon
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In a large individually randomized trial embedded in routine care across a national U.S. health system, a cardiovascular-focused nudge intervention did not increase influenza vaccination rates on a background of low-uptake. Full trial results: https://t.co/hPspOt6JwS
#ESCCongress
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The countdown is on! DANFLU-2 will be presented at #ESCCongress on Saturday! 332,438 adults ≥65 years 👵👴 High-dose vs standard-dose influenza vaccine 💉 Severe outcomes: hospitalizations and deaths 🏥☠️ Design paper: https://t.co/BcqEe1xT8I Look out for simpubs! 👀
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Very pleased to share our review on AI echocardiography in cardiovascular disease management is now published! I hope this article serves as a resource for continued learning, discussion, and collaboration across the field. 🔗 https://t.co/Ue44ZofLpf
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🧵1/Today, we published a key milestone towards AI based cardiac screening in Nature. https://t.co/Lr3ymIrgz5 EchoNext outperformed cardiologists and found thousands of high-risk patients missed in routine care. We also made a version available to the world.
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Aldosterone synthase inhibitors offer an alternative strategy to target a classic pathway in hypertension, renal, and CV disease In @MedCellPress, @lamcardio and I review recent ASI trials in hypertension and future evaluation in HF & CKD https://t.co/CMqK8tkGG9
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Rationale, Design, and Baseline char. of KP-VACCINATE out in @AmericanHeartJ. ~3.8 Million adults randomized in 2 integrated learning healthcare systems in ~4 weeks. To our knowledge, the 🌟largest RCT ever🌟 & fully embedded in routine case. Results soon https://t.co/EqJwSII5Yc
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Excited that #PanEcho is now published in @JAMA_current Kudos to @giholste @ekoikonomou for leading this incredible effort! Now also validated on ED POCUS studies + RVNet+ (Thx Attila Kovacs & Marton Tokodi for joining us) See 🧵 below for details! https://t.co/llgC3D19u6
After 2 months of embargo for #AHA24 Late Breaking presentation, we are pleased to announce PanEcho - Complete AI-enabled echocardiography interpretation with multi-task deep learning Led by @giholste & @ekoikonomou @cards_lab Preprint, code, model here:
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Fortunate and honored to be selected as a recipient of Heart Failure Research Foundation Emerging Leader Grant! Thanks to my colleagues, mentors, @HFSA for their support and guidance! @BrighamWomens @bwhcvls @MGBResearchNews @harvardmed #heartfailure #research
The Heart Failure Research Foundation is honored to announce its first ever grant awards thanks to the generosity of our donors. Our Emerging Leader Grants program supports early investigators in heart failure research. The HFSA Board and Research Committee bestowed the inaugural
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New results from #FINEARTSHF in @ESC_Journals #EJHF, in time for #HeartFailure2025 Finerenone reduced HF events and CV death in HFmrEF/HFpEF consistently, regardless of baseline NT-proBNP And reduced NT-proBNP 12% vs placebo at 3 & 12 months https://t.co/Ocena7FP46
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🔥Incredible Cardiology GR presentation by @Stanford_HF's @SunnyVMD on the state of device therapy in HF & another fantastic career path for prospective HF fellows‼️ @Stanford @mvaduganathan @FudimMarat @noshreza @RyanTedfordMD @robmentz @dranulala @ankeetbhatt @KiranKhush1
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In @JACCJournals #JACCHF, @coconnormd and share our vision for "The Future of AI-Assisted Event Adjudication" AI adjudication may provide the consistency of a CEC without expense & delays https://t.co/Z9Ck8RpHQH
jacc.org
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Hear directly from our members as they share why #HFC plays a vital role in shaping the future of #heartfailure #research & care. From improving #clinicaltrials to fostering collabs across sectors, HFC is where progress begins. #cardiotwitter #heartfailurecollaboratory #Cardio
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