John Noone
@JohnNoone4
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Assist Prof @UL | Postdoc @AdventHealth TRI | Prev. Postdoc @tcddublin @tcdTBSI | PhD @DCU @dcu_shhp | BSc @DCU @dcu_shhp | Physiology | Bioenergetics | MoTrPAC
Limerick, Ireland
Joined March 2013
Thrilled to be appointed as Assistant Prof. in Sport & Exercise Physiology within @PessLimerick. Excited to continue the research I have conducted to date here, and to work within such a great department & university along the banks of the river Shannon.
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RT @JPhysiol: Recent #Research by Maude Dulac (@McGillMed) et al. finds that a #multimodal exercise countermeasure prevents the negative im….
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RT @CoenPM: Delighted to share a recent publication from a long standing collaboration with @SiobhanMalany, Maddalena Parafati, and their o….
cell.com
In this article, Parafati, Malany, and colleagues show that microgravity altered contractile response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS. Electrical stimulation...
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RT @NaturePortfolio: A study in @NatMetabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative….
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RT @GGouspillou: Early-life exercise extends healthspan but not lifespan in mice | Nature Communications
nature.com
Nature Communications - Exercise exerts health benefits, yet the long-term effects of early-life regular exercise on later-life health and lifespan remain poorly understood. Here, the authors show...
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RT @JuleenRZierath: Our latest: HIF1α mediates circadian regulation of skeletal muscle metabolism & substrate preference in response to tim….
pnas.org
The regulation of metabolism in peripheral tissues is intricately linked to circadian rhythms, with hypoxia-inducible factor-1α (HIF1α) implicated ...
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RT @CraigAGoodman1: Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise..
ahajournals.org
Skeletal muscle is essential for movement and maintaining energy homeostasis and is the primary tissue for insulin-stimulated glucose uptake. Skeletal muscle is composed of various cell types that...
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RT @D_Morales_Alamo: 🚶♂️🧬 A recent study shows that, when matched for age, sex, and BMI, skeletal muscle mitochondrial respiration and mor….
link.springer.com
Diabetologia - Previous studies reporting lower skeletal muscle mitochondrial function in type 1 diabetes did not account for cardiorespiratory fitness, a key confounder when assessing...
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RT @D_Morales_Alamo: 🔬 Researchers in @NatureComms (2025) discovered that #mitochondria adopt a constricted morphology during respiration.….
nature.com
Nature Communications - Singh et al. report a constricted mitochondrial morphology called Ringo that forms during respiration growth in yeast. Inhibition of Ringo formation correlates with...
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RT @HughesDC_Muscle: Muscle regeneration is improved by hot water immersion but unchanged by cold following a simulated musculoskeletal inj….
pubmed.ncbi.nlm.nih.gov
Cryotherapy is a popular strategy for the treatment of skeletal muscle injuries. However, its effect on post-injury human muscle regeneration remains unclear. In contrast, promising results recently...
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A pleasure to write this perspective on AT energetics. Many thanks to @JPhysiol . There is a real need to uncover more within this tissue with advancement in treatments of obesity. @PessLimerick .@EHSFacultyAtUL .@HRI_UL .@PAfH_UL .@SportHumanPerf.
physoc.onlinelibrary.wiley.com
Click on the article title to read more.
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RT @Cell_Metabolism: New! Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging https://t.c….
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RT @CraigAGoodman1: Phosphoproteomics Uncovers Exercise Intensity-Specific Skeletal Muscle Signaling Networks Underlying High-Intensity In….
link.springer.com
Sports Medicine - In response to exercise, protein kinases and signaling networks are engaged to blunt homeostatic threats generated by acute contraction-induced increases in skeletal muscle energy...
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Wonderful to see this published in MSSE. Congrats to all involved (🇺🇸&🇮🇪). Exploring the relationship between RAR and CRF & walking energetics in older adults:.
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RT @dnewmire: So it’s not lactic acid? 😊 “intracellular acidosis is not the sole cause of fatigue. Fatigue factors (e.g., phosphate metabol….
link.springer.com
European Journal of Applied Physiology - During high-intensity exercise a lactic-acidosis occurs with raised myoplasmic and plasma concentrations of lactate− and protons ([lactate−],...
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RT @DrDylanThompson: New PhD opportunity in nutrition and metabolism at @UniofBath - closing date 31st March. Come and join @CNEM_Bath! @Go….
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RT @Mito_Crue: Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1
nature.com
Nature - We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity,...
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RT @PessLimerick: In today’s blog, PESS staff member @JohnNoone4discusses his recent recognition of top journal impact factor for his manus….
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RT @ExpPhysiol: How does ageing impact type I and type II myofibre properties in human muscle? @HorwathOscar, @MobergPhD, @SebastianEdman,….
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Just arrived in the mail. I want to thank @AdventHealth and for everyone involved in the process. Very kind and much appreciated.
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RT @DrBPCarson: Proud of our latest paper 'Comparative response of casein protein hydrolysate-fed young & older.human serum on in vitro mus….
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