Dave Hughes
@HughesDC_Muscle
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Assistant Professor | @AM_OMRF | Skeletal Muscle, Atrophy, Aging, Protein Quality Control (PQC) | Views my own | 📚💪🏼🇬🇧 #myotwitter
Oklahoma City, OK
Joined August 2011
New review from myself & @scbodine in @ESSRonline | #myotwitter UBR5: A New Player in Protein Quality Control for Skeletal Muscle Growth and Remodeling https://t.co/rbpjBc7q6I 1/3
journals.lww.com
ophy and regrowth and interacts with protein synthesis. We present the novel hypothesis for protein quality control being critical for skeletal muscle growth and remodeling....
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From our own Dr. Benjamin Miller's Edward F. Adolph Distinguished Lecture: Protein and energy metabolism: a state of flux
journals.physiology.org
Physiology processes are integrated, dynamic, and periodic and thus benefit from methods that capture their dynamic nature. Since we are often limited to discrete sampling points in physiological...
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The effect of bed rest, unilateral limb immobilization and head-down tilt on muscle protein synthesis: A systematic review and meta-analysis Fun collab with @KostasProko @_PaulMorgan @csbd7 @OllyWitard
https://t.co/VWuTplTkE7
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Cachexia progression differs among mouse models of metastatic triple-negative breast cancer https://t.co/n1drPKn6wl
journals.physiology.org
Cancer-associated cachexia decreases the quality of life, reduces therapy response, and diminishes survival prospects. Effective cachexia countermeasures remain a significant unmet need. Research...
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Our data reveal a spatially organised, multicellular response that begins within hours of mechanical loading. Our snRNAseq atlas of the human muscle-tendon unit offers a foundation for future studies on exercise & more! 📄 Read it here:
journals.physiology.org
Mechanical loading drives structural and functional improvements in muscle and tendon, protecting against injury at their interface − the myotendinous junction (MTJ) − and within the tendon matrix....
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‘digital assets’ will run back the 1990s dot com playbook through the latter half of the 2020s. We are at the tip of broad adoption around crypto and digital assets, which will kick off a multi-year speculative bubble that would put 2021-era NFTs to shame. Want to know why?👇
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This week in Muscle Science: fresh insights into how muscle talks, adapts, and protects us across the lifespan. From regeneration to metabolism, the field is firing on all cylinders . Check it out👇 https://t.co/zGeb4vaee1 Highlighting: @HughesDC_Muscle
@anna_picca
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Does muscle remember disuse muscle wasting? Our new study just out shows skeletal muscle retains a molecular memory of disuse! Young muscle shows transcriptional resilience to repeated atrophy Aged muscle shows exaggerated susceptibility https://t.co/T0SsBXLYMk
biorxiv.org
Disuse-induced muscle atrophy is common after illness, injury, or falls, and becomes increasingly frequent with ageing. However, whether skeletal muscle retains a “memory” of disuse remains unknown....
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Influence of skeletal muscle heterogeneity on autophagic signaling and response https://t.co/dqcRi9h2zw
tandfonline.com
Skeletal muscle is a heterogeneous tissue composed of fibers with distinct contractile, metabolic, and molecular characteristics. This intrinsic heterogeneity influences how individual fibers respo...
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If you are excited to learn more about intramuscular adipose tissue (how it forms, what it does & how to study it), see our newest review we wrote in collaboration with @lab_meyer. #myotwitter. https://t.co/gWxyZowTQN
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Checkout the new paper from Leslie Baehr, @HughesDC_Muscle & Team, which also involved the CMR's @CraigAGoodman1 Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size https://t.co/APhPfErAMa
journals.physiology.org
The N-degron pathway contributes to proteolysis by targeting N-terminal residues of destabilized proteins via E3 ligases that contain a UBR-box domain. Emerging evidence suggests the UBR-box family...
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In this review, we describe the pathophysiology of sarcopenia and cachexia, explore their definitions in the context of geriatric oncology, and examine assessment methods used in clinical practice. Great job Makis. @lsuchse @acsmnews @skppowers
https://t.co/LdLCtSohTh
link.springer.com
Drugs & Aging - Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes and undermine quality of life among older adults with...
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Congratulations to the CMR's @KristySwidersk1 and @GordonSLynch for their new review paper on "Translational progress in the development of pharmacotherapies for Duchenne muscular dystrophy" https://t.co/VpjEsK6fx7
@UniMelbMDHS @MDAust @MDAorg
tandfonline.com
Despite the discovery, nearly 40 years ago, that mutations in the dystrophin gene were responsible for Duchenne muscular dystrophy (DMD), a cure for this devastating disease remains elusive. Consid...
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Signaling networks governing skeletal muscle growth, atrophy, and cachexia | Review #myotwitter
skeletalmusclejournal.biomedcentral.com
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CORP: In Vivo Muscle Strength- Perspectives on the Design and Interpretation of Preclinical Animal Studies https://t.co/fcTO45ObKY
journals.physiology.org
Accurate and reproducible tools to evaluate skeletal muscle contractility help to advance the field of physiology by defining skeletal muscle function in the context of skeletal muscle development,...
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🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important. Some travel to CPH involved as well! https://t.co/88blHJGQXS
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Our current preprint sought to explore the interplay between this sub family of E3 ligases and protein synthesis signaling 💪🏼 https://t.co/K3DW2oQypC 3/3
biorxiv.org
The N-degron pathway contributes to proteolysis by targeting N-terminal residues of destabilized proteins via E3 ligases that contain a UBR-box domain. Emerging evidence suggests the UBR-box family...
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We discuss emerging evidence for specific UBR-box E3 ligases in skeletal muscle adaptation and remodeling. Ideas presented in this review highlight the specialization of the UPS system in skeletal muscle plasticity. 2/3
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The multimodal transcriptional response of denervated skeletal muscle involves regulation of Gramd1 genes impacting muscle size https://t.co/2K5vFyFRce
pnas.org
The development and maintenance of the neuromuscular junction (NMJ) requires reciprocal signals between the nerve terminals and multinucleated skel...
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Combined Weight Loss and Exercise Training Alters Skeletal Muscle Subcellular Lipid Localization and Intermuscular Adipose Tissue Cellular Composition | #myotwitter
pubmed.ncbi.nlm.nih.gov
Evaluation of subcellular fractionated muscle revealed decreases in sarcolemmal and nuclear triglycerides and increases in nuclear diacylglycerols and cytosolic sphingolipids postintervention. Weight...
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Semaglutide impacts skeletal muscle to a similar extent as caloric restriction in mice with diet-induced obesity | #myotwitter
pubmed.ncbi.nlm.nih.gov
Semaglutide is a GLP-1 receptor agonist that is highly efficacious in reducing food intake and body weight. While semaglutide reduces adipose tissue, there is also a loss of lean mass including...
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