Jingyi Chen, PhD
@Jingyi_Neuro
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Postdoc @UW Bruchas lab. @JCChildsFund fellow. Scientist studying neuromodulation.
Seattle, WA
Joined August 2013
Hi! My name is Jingyi; I'm a postdoc in Dr. Michael Bruchas's lab. This pandemic has taken some pieces of life away from everyone, and for me, it took away my chances to present my thesis work to the community.
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RT @NutritionNerd: [Disclaimer: I don’t know that the below is accurate, so someone that has this information, please share] 🧵 . With all o….
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RT @DavidJMarcus2: Hello ACNP! I'm David and I am a postdoc in the @mbruchas lab at the University of Washington studying how endogenous c….
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Hi ACNPer @ACNPorg. My name is Jingyi and I'm a postdoc in the Bruchas lab. Come check my poster T203 today from 5-7 p.m. on Claustrum Dynorphin/KOR modulation during stress induced binge eating behaviors!
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RT @outRaajeous: Hi #ACNP2024! I'm a NIDA K99 postdoc in Michael Bruchas' lab at UW, interested in how endogenous opioids promote goal-dire….
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We will continue to study how the Insular-Claustrum circuit modulates stress-eating behaviors and the balance between glutamate/dynorphin signals from these Insular Pdyn+ neurons.
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When we stimulated Insular Pdyn+ terminals in the Claustrum, we observed increased calcium activities in the Cluasturm vGat populations. Phamcology manipulation with U50 (KOR agonist) disturbs these increases.
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Then, we identified the anterior insular cortex Pdyn+ neurons projected to the Claustrum. The insular-Claustrum circuit likely mediates stress-induced binge eating through a disinhibition structure. The Claustrum vGat+ neurons are activated during feeding.
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By directly recording the Claustrum dynorphin dynamics using a genetically encoded dynorphin sensor developed by @LinTianPhD lab, we found binge eating temporarily reduced the Claustrum dynorphin signal. Suggesting binge eating is a stress-alleviating behavior.
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We found this effect depends on the dynorphin/Kappa-opioid receptor (KOR) signaling in a brain region called the Claustrum. With 1-photon imaging, we found the Claustrum neurons are very heterogeneous and are modulated by dyn/KOR signaling and stress.
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Eating a lot of potato chips or ice cream when you're stressed? Don't worry, you're not alone. We found mice binge eating palatable food (high sugar, high fat) after acute stressors as well.
Endogenous opioids facilitate stress-induced binge eating via an insular cortex-claustrum pathway #biorxiv_neursci.
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Check out this amazing work from @outRaajeous. Elegant work to look at neuromodulation across seconds, minutes, and days and how they tune behaviors at different timescales. He's a thorough and creative scientist whom I'm so privileged to work with. And HE IS ON THE JOB MARKET!.
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RT @outRaajeous: Excited to share our work in the @mbruchas lab on how endogenous opioids promote goal-directed behavior, funded by @NIDAne….
biorxiv.org
Endogenous neuropeptides are uniquely poised to regulate neuronal activity and behavior across multiple timescales. Traditional studies ascribing neuropeptide contributions to behavior lack spatiot...
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Nice to catch up with old friends and making new friends with the first year fellows. Again, nothing but gratitude for being a member in this amazing family ❤️ （7/7）.
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Really enjoyed all the behind the scene story from Avice about the establishment of the Janelia Campus, the incredible sea worm that can regenerate their entire brain, exciting dinner with the one and only @DulacLab sitting next to me!! （6/7）.
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Please check out Everycure: There are thousands of rare diseases out there without treatments and the cure could already exists! We just need to connect the dots and we all can contribute! (5/7).
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Then it's Dr. David Fajgenbaum's talk that really touched my heart. I admire how he makes us laugh when he talks about all these near death experience and his incredible hard battle against the Castleman diseases. （4/7）.
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And I saw her taking notes for everyone's talk and even stayed with us for the career workshop. A mentor who cares and treats trainees with love and respect. A true model for me! （3/7）.
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It's so inspiring to hear the story about Dr. Joan Steitz and from her trainees! How she supports Rachel by offering her time off and a part time postdoc position so she can stay in academia while being a mom and take care of her family is so lovely.（2/7）.
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Another great JCC annual meeting! I feel so grateful for being a part in this family. Thanks for everyone from the @JCChildsFund for putting this together and here are some of my favorite moments of this year's annual meeting : （1/7）
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First MPA meeting in beautiful Big Island! Come check out my poster #27 tomorrow morning at 7 a.m. for neuropeptide regulation for stress induced binge eating.
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