Dr Jessamy Tiffen
@JessTiffen
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Group Leader, Melanoma Epigenetics Laboratory, The Centenary Institute. Head of Centre for Cancer Innovations, The Centenary Institute
Sydney, New South Wales
Joined July 2012
Thrilled to share new work led by @JieYang437 in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre
https://t.co/dO2v0GWKAn
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Deeply concerned for my US collaborators……
In an unprecedented move, research-grant reviews have been suspended indefinitely at the world’s largest public funder of biomedical research https://t.co/rEmlD6lFgE
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1. What are the benefits and risks of GLP1? Our new study in @naturemedicine comprehensively maps all the benefits and risks of GLP-1 receptor agonists (GLP-1) (Ozempic, Wegovy, Mounjaro, Zepbound). By @Biostayan, Taeyoung Choi and me 🧵 https://t.co/cJR8t1fZU8
nature.com
Nature Medicine - An atlas of the associations between the use of GLP-1 receptor agonists (GLP-1RAs) and 175 health outcomes reports the effectiveness and risks of GLP-1RAs compared with other...
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Cancer statistics in 2025 🇺🇸- new report 🚨 Cancer is becoming a new disease. We're seeing a fundamental shift in who gets cancer, moving from a predominantly male, elderly disease to one that increasingly affects women and younger people. Key highlights 🧵
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Super fun BBQ and swim at my house for past and present lab members and their families. Stephen and Alice are about to graduate with their MDs. Great science is so much more about the people than experiments. @DrHYTseng @CentenaryInst
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SEX! Now that I have your attention, check out our review on these fascinating yet under appreciated chromosomes with roles in cancer survival outcomes.
onlinelibrary.wiley.com
Role of X and Y gene expression in the improved survival of females from cancer. Created with BioRender.com.
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Looks like it’s back to the ARC grants. #AcademicTwitter
According to NBC, “Raygun” has a PhD in cultural studies and teaches about breaking, hip-hop culture, and gender studies related to these specific dances. This is Napoleon Dynamite level stuff.
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Super grateful to the AMRF for supporting Laura’s project on an epigenetic switch for undifferentiated melanoma.
Congratulations to Dr @JessTiffen & master’s student Laura Nicholls, who have been awarded a $10,000 research grant from @MelanomaAU . The grant will support Laura’s study into a resilient type of melanoma that often evades current treatments. More: https://t.co/mBZHkH0YVE
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The 10 biggest cancer papers of the last 10 years (in my opinion) 1. Blocking PD1 activates the immune response against cancer - especially if the cancer has more mutations https://t.co/rBCVRcDfvo
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You're invited to our FREE interactive online event Skin Deep: understanding melanoma. For more information and to register go to: https://t.co/5FY3DPp0F1
#centenaryinstitute #melanoma #medicalresearch #medicalwebinar
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I am looking for a post doc to join my new lab @Sydney_Uni! This is a great opportunity for an ECR to work with my team using cutting edge imaging approaches 🔬 to dive into bone metastatic breast cancer … and enjoy the Sydney life ☀️ 🏖️🤗
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More great work from my team on epigenetic BET inhibitors. Here we show they combine well with antiCTLA-4 immune checkpoint inhibition (ICI) to combat melanoma with innate resistance to antiPD-1/L1 (frontline) ICI in a mouse model. @DrHYTseng @emran_geb
https://t.co/FhEvXXg3Gz
onlinelibrary.wiley.com
Approximately 50% of melanoma patients fail to respond to immune checkpoint blockade (ICB), and acquired resistance hampers long-term survival in about half of initially responding patients. Whether...
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This is remarkable. Cancer in the complete absence of a single genetic mutation. Another win for team epigentics!
nature.com
Nature - A transient perturbation of transcriptional silencing mediated by Polycomb proteins is sufficient to induce an epigenetic cancer cell fate in Drosophila in the absence of driver mutations.
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Like Catherine, more under-50s are being diagnosed with cancer
smh.com.au
Globally and in Australia, more people are being diagnosed with cancer before their 50th birthday.
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Estimating cancers attributable to physical inactivity in Australia - Journal of Science and Medicine in Sport
jsams.org
It was previously estimated that 1814 (1.6 % of incident cancers) were attributable to physical inactivity in Australia in 2010, when only three sites were considered. We estimated the burden of...
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FDA approves first tumour-infiltrating lymphocyte (TIL) therapy, bolstering hopes for cell therapies in solid cancers
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When you meet with cardiology folks on Valentines Day, you get heart shaped treats ❤️@Vrushalikc @CSHeartResearch @rdbagnall
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The @JessTiffen lab is focused on understanding how epigenetic dysregulation drives melanoma development & how this differs between the sexes. More: https://t.co/YO7VIqiWz4
#worldcancerday #closethecaregap #centenaryinstitute #WorldCancerDay2024 #melanoma #Cancer #CancerResearch
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It's a mistake to think that the only wins in the #PhD worth celebrating are the big flashy events - submission, acceptance, awards. Here are 30 other wins in the PhD you might think are "no big deal" 🧵 #phdlife #phdchat #academicchatter #academictwitter #phdtips
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