Jared Coombs
@JaredCoombs_
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PhD candidate in the @inflammasomelab investigating ✨inflammasomes✨💅 | @IMBatUQ | he/him
Brisbane, Queensland
Joined September 2022
Ever wondered how NLRP12 can drive autoinflammation? 👀 In our latest work, we show that NLRP12 is an endogenous inhibitor of NLRP3 inflammasome formation, but disease-causing NLRP12 mutants lose this capacity 🤯
New exciting work from the @inflammasomelab just out! Congratulations to @JaredCoombs_ , @DrAlinaZ , @CarolineLHolley and others! NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome | Science Signaling
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Non-alcoholic fatty liver disease (NAFLD) affects ~30-40% of adults NAFLD progresses through stages - the latest stage that's still reversible is NASH (nonalcoholic steatohepatitis) There have been no drug therapies for NASH - until three recent trials 🧵
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It is out! 🚨 Phosphorous-free bacterial lipids can switch between pro- and anti-inflammatory depending on context!🔬 #Immunology #LipidBiology @PelegrinPablo @inflammasomelab A big thanks to the reviewers and editors. It was a laborious but smooth process🥳
Ornithine lipid is a partial TLR4 agonist and NLRP3 activator
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easy breezy beautiful... covergirl 💅
Issue 13 is complete! Explore our ToC here: https://t.co/DXEBQqFSkg Our cover image shows a bead sprouting assay of HUVECs expressing a c-Src mutant (magenta). The cells exhibit irregular blood vessel formation with actin in green & DAPI in blue. From @TEssebier et al.
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Researchers have discovered how the 'on-switch' for the body's inflammation machinery can get stuck, paving way for potential treatments for rare genetic inflammatory diseases. 🔗 https://t.co/w4ua0y1umr Prof Kate Schroder (@inflammasomelab),@JaredCoombs_,Dr Alina Zamoshnikova
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Nice to see the review written by @_KateLawlor , me and the X-less James Vince on the nuts, bolts and consequences of MLKL and GSDM lytic cell death out now in @ImmunityCP Check it out with a free download at: https://t.co/5ygomIpwgw
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Studying mice and cells from patients with an autoinflammatory condition, a team finds the #inflammasomes NLRP3 and NLRP6—but not NLRP12—initiate formation of ASC specks and that NLRP12 may suppress NLRP3. @IMBatUQ @inflammasomelab @JaredCoombs_
https://t.co/Q7yju1Sa02
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Huge congratulations to everyone who contributed to this work over the years, especially the brilliant @DrAlinaZ and @inflammasomelab 👏👏👏 @IMBatUQ
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Delighted to share a new methods paper from @CarolineLHolley and @inflammasomelab for Live Imaging of Pyroptosis in Primary Murine Macrophages! https://t.co/2lZUH0rJus
link.springer.com
Inflammasomes are the ultimate weapon of the macrophage immune arsenal. Inflammasome signalling in macrophages triggers pyroptosis, a lytic cell death pathway that facilitates inflammation-driven...
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Excited to share a method developed by @S_Emming @inflammasomelab and our friends at Quench Bio for Quantifying Cell Death Induced by the NLRC4 Inflammasome! https://t.co/8rLDkOa2XT
link.springer.com
The Nod-like Receptor (NLR) apoptosis inhibitory proteins (NAIPs) are cytosolic receptors that sense cytosolic bacterial proteins. NAIP ligation induces its association with NLRC4, leading to the...
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Research highlight: @jazzy_yup, @S_Emming & Prof Kate Schroder @inflammasomelab comment on work from Zhang et al. providing key insight into regulatory mechanisms governing NLRP1 activation and potential for structure-based anti-inflammatory drug design
onlinelibrary.wiley.com
The biology of the NACHT domain and leucine-rich repeat (NLR) and pyrin domain-containing 1 (NLRP1) inflammasome has perplexed researchers since it was first described about two decades ago. The...
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We start the Inclusivi-Tea Time event series every first Monday of the month 10:30 on the rooftop @IMBatUQ A simple formula for IMB members from diverse career stages, paths, marginalised backgrounds, and identities build connections and empower each other. ☕ paid by @EMCRA_IMB
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"In these times when we have a lot of problems to solve, we can't afford to waste talent." Hear chemistry laureate Michael Levitt speak about the importance of diversity. #NobelPrize
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Congratulations to Prof Kate Schroder (@inflammasomelab), winner of the IMB Inflazome Translation Award 🏆 and Dr Harrison Madge, winner of the Ignite Innovation Award 📷 at this week's Research Engagement Dinner.
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To our First Australians: I’m sorry. As a country, Australia should have done better for you today.
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We are so grateful to be able to host A/Prof @FZMarques yesterday and today at @IMBatUQ! Not only did we hear about her incredible research on the gut #microbiota and #hypertension, we also discovered ways to champion diversity in science. Thank you once again for visiting 🙏
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During the twentieth century, women’s education levels continuously increased, and in most high-income countries they are now substantially higher than for men. Claudia Goldin – awarded the 2023 prize in economic sciences – demonstrated that access to the contraceptive pill
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Can your research be a work of art? We're excited to announce our Paint n Sip event on Friday 13 October, hosted in the lead up to the Jo Underhill Art Competition! Starting from 4pm on the QBP Rooftop, all supplies will be provided, just bring your best idea! See you there!
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At @EMCRA_IMB we are thrilled to host @FZMarques for a workshop entitled: Advocating for #genderequity –what you can do to drive #change. This is gonna be all about strategies, not just chatting! Register here: https://t.co/DpD3JVY5BL
@IMBatUQ
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