Jakob Langer
@JakobJLanger
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Bioengineered GI organoids just got an upgrade! Our new Transgel system combines 3D complexity with bilateral accessibility & remarkable observability, enabling advanced studies on tissue dynamics, stem cell niches, and host-pathogen interactions.🔬 👉 https://t.co/OeiSs0ehdO
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A Site-Specific #ClickChemistry Approach to Di-Ubiquitylate H1 Variants Reveals Position-Dependent Stimulation of the DNA Repair Protein RNF168 (Beat Fierz and co-workers) @_paulinefranz, @Beatfierz, @EPFL_en #openaccess
onlinelibrary.wiley.com
We developed a click chemistry approach to di-ubiquitylate histone H1 at relevant DNA repair-associated positions (H1KxUb2) to probe its effect on the E3 ligase RNF168. We demonstrate that H1KxUb2...
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Thymic epithelial organoids mediate T-cell development https://t.co/OoxNK4Poa5 Our story on developing a new model to study the #thymus is now published @Development! We identified culture conditions where single sorted thymic epithelial cells develop into #organoids.
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Also in this issue, a #ToolsoftheTrade by @LFranciscoLM & @TheLutolfLab @EPFL: Mini-colons unlock tumour development outside the body https://t.co/C5QOJFRrlJ
#NRGToT
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Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity https://t.co/elhMQS9o6O
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Following our recent breakthrough on mouse mini-intestines for ex vivo tumor development, we asked ourselves: can this technology be applied to cells from cancer patients? We are excited to announce the answer to this question in our latest publication: https://t.co/Uck4EyBXeK
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Thrilled to share our latest work in @NatureBiotech! Discover how tissue-engineered mini-colons can advance our understanding of patient-specific colorectal cancer biology:
Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity https://t.co/elhMQS9o6O
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This work was spearheaded by the hugely talented @LFranciscoLM and @TaniaHubscher, and supported by our collaborators Amber Bowler, @NicoBroguiere, @JakobJLanger, Lucie Tillard, @mike_nikolaev, and @isrec_radtke. Thank you all!!
This opens up exciting prospects for cancer research as it provides a powerful tool for mechanistic studies and testing of potential therapies, especially when applied to human patient-derived organoids - stay tuned for follow-up work also from the @IHB_Research!
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This opens up exciting prospects for cancer research as it provides a powerful tool for mechanistic studies and testing of potential therapies, especially when applied to human patient-derived organoids - stay tuned for follow-up work also from the @IHB_Research!
Mini-colons display rich intra- and inter-tumoral diversity and recapitulate key pathophysiological hallmarks displayed by colorectal tumors in vivo. By fine-tuning cell-intrinsic and -extrinsic parameters, these mini-colons can be leveraged to unveil tumorigenic determinants.
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Have you ever seen real-time footage of a tumor developing outside a living organism? We are thrilled to announce a new paradigm in ex vivo cancer modelling https://t.co/N619EGEFgc. Let’s have a quick look!
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These organoids maintain thymus functionality and mediate physiological T cell development upon reaggregation with T cell progenitors. Huge thanks to all collaborators @LFranciscoLM, @JakobJLanger, Thomas Bartlott, Lucie Tillard, Paul Rouse, Clare Blackburn and Georg Holländer!
Check-out our latest preprint on thymic epithelial organoids! https://t.co/7H4PS4vqHX Fabulous work by @TaniaHubscher 👏🥳!!
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Excited to share our latest preprint on human mini-guts! https://t.co/rqQctWaDui Great work by @olga_mitrofan 🙌🎉
biorxiv.org
Organoids and microphysiological systems, such as organs-on-a-chip, have emerged as powerful tools for modeling human gut physiology and disease in vitro . However, although physiologically relevant,...
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Happy to see JiSoo Park’s work on mouse neural tube organoids published https://t.co/rZyDHby1fk 👏🎉!! Not quite a #SyntheticEmbryo… but still impressive display of the self-organization capacity of stem cells. Check out the neural crest cells that emerge from these organoids!
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Exciting collaboration with the @PetrovaLab, thanks for involving us! Great potential for modelling nutrition with next-gen organoids.
❣️❣️Just published ❣️❣️ c-Maf sustains zonation, lipid handing and tuft cells in small #intestinal #villi
https://t.co/BYC9iDZa7Y Great collaboration with @JakobJLanger @TheLutolfLab to study lipid uptake in cool “mini-guts”🤩 👍Ale, @IrenaRoci, @JbernierLatmani+collaborators!
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Happy to present our new preprint on a deep-learning based method for rapid localization of transition metal ions in protein structures: Metal3D. Work done with @andrea_levy and @lcbc_epfl 1/6 https://t.co/cv1xrNEaAQ
Accurate prediction of transition metal ion location via deep learning https://t.co/7QEwzTG2ux
#bioRxiv
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I enjoyed my first presentation @VIBLifeSciences #VIBTraining in Leuven today! I’m grateful for the opportunity to share some insights into our culture model together with @MatthiasLutolf and enjoyed exciting talks!
During the first session, we had inspiring talks by Arnold Kriegstein @Kriegsteinlab, Madeline Andrews @Andrews_MG, Matthias Lutolf, and Jakob Langer @TheLutolfLab. Looking forward to hearing more! Read the program here 👉 https://t.co/DY5O9sErQg
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