Jacob Vorstman 🇺🇦
@Jacob_Vorstman
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Father of four, husband of one. Child psychiatrist & researcher genetics & development, autism, schizophrenia, 22q11DS. Hospital for Sick Children Toronto
Toronto, Canada
Joined January 2009
Murthy et al. report that monoallelic loss of function variants in the DENND2B gene give rise to an autosomal dominant neurodevelopmental disorder characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia. https://t.co/0ZcfdFxt1I
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Recent claims by the U.S government linking Autism to acetaminophen, vaccines & leucovorin lack scientific evidence. At SickKids, we’re committed to evidence-based research. Read SickKids' statement on these claims ⬇️ https://t.co/x45Y2Wx6M8
sickkids.ca
SickKids experts provide commentary on recent White House claims about Autism.
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🧠 New discovery: #SKResearch in @Brain1878 identifies a brain condition with #psychosis & #catatonia linked to the DENND2B gene. Using zebrafish & computational tools, researchers showed these changes disrupt brain cell function. 🔗 https://t.co/UHjGHUoRX9
#PrecisionChildHealth
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Super stoked to share our new paper in @Brain1878 . This is the result of several years of intense collaborative work across labs and many international borders.
Murthy et al. report that monoallelic loss of function variants in the DENND2B gene give rise to an autosomal dominant neurodevelopmental disorder characterized by developmental delay, intellectual disability, and episodes of psychosis and/or catatonia. https://t.co/0ZcfdFxt1I
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Variants in DENND2B are associated with vulnerability for neurodevelopmental impairment, psychosis and catatonia #RareDisease #Genetics
academic.oup.com
Murthy et al. report that monoallelic loss of function variants in the DENND2B gene give rise to an autosomal dominant neurodevelopmental disorder characte
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Variants in DENND2B are associated with vulnerability for neurodevelopmental impairment, psychosis and catatonia
pubmed.ncbi.nlm.nih.gov
Altogether, these findings suggest that monoallelic loss of function variants in DENND2B cause a novel autosomal dominant neurodevelopmental disorder with variable vulnerability for psychosis and/or...
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Xavier Le Pichon, a French geophysicist whose pioneering model of the earth’s tectonic plates helped revolutionize the understanding of movements of the earth’s crust, has died at 87.
nytimes.com
With a computer rendering, he helped scientists understand that the earth, with its shifting tectonic plates, is “an extraordinary living being” that is “continuously changing.”
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Xavier Le Pichon, Who Modeled Movement of Earth’s Crust, Tectonic Plates, Dies aged 87 - The New York Times
nytimes.com
With a computer rendering, he helped scientists understand that the earth, with its shifting tectonic plates, is “an extraordinary living being” that is “continuously changing.”
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explainer for the tech bros. 60% is added on top of direct cost (and equipment are not included). So for every dollar that goes to a scientist, roughly $0.80 is allowable. Then you add 60% facilities/admin costs on top ($0.48). Uni’s final cut is $0.48/$1.48 =0.324 of the grant
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Your math is wrong dude. Let me get this straight. All this time you thought a that an indirect cost rate of 60% meant that Universities took 60% of the grant? 🤦♂️
Can you believe that universities with tens of billions in endowments were siphoning off 60% of research award money for “overhead”? What a ripoff!
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Children with neurodevelopmental delays and a genetic mutation were more likely to be female and have a history of early interventions and other health issues: https://t.co/OTR4uxTvKt
#NeuroTwitter @AANMember @besterman_a @AndreaGropman @Jacob_Vorstman
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Thank you to @UofT for making your voice heard- Ford's plan to remove bike lanes costs money that is sorely needed elsewhere in our city and makes our communities less healthy and less safe. #TOpoli @CycleToronto #toronto
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Sincere apologies to @fordnation for once again contributing to traffic congestion downtown #Toronto with my terrible habit of riding my #bike instead of my car. Forgive me!
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Take-home message was the importance of collaboration and representation of diverse ancestries in psychiatric genomics research. #genomics #sequencingstudies #psychiatry #WCPG2024
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A big thank you to our chairs Aiden Corvin and @mcintosh2001, our speakers @Jacob_Vorstman, Cathal Ormond, David Glahn and @gsuhasg and our discussant @DrNiamhRyan for a fantastic session!
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#ThrowbackThursday to the Pedigree Sequencing Symposium at the World Congress of Psychiatric Genetics in Singapore last month where we showcased the stellar work being carried out in this field. #psychiatry #genomics #WCPG2024
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At Council today, with a 21-4 vote, the Mayor and City Council voted for respecting local democracy, and made clear its opposition to Bill 212. With this message, we’re redoubling our focus on stopping this unprecedented provincial overreach and protecting our bike lanes. 3/
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Thousands of Ontario residents came together to send a message to @fordnation and @PrabSarkaria that bike lanes save lives, solve congestion and transport goods.
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Thomas has been instrumental in supporting the first international research collaboration on the psychiatric consequences of the #22q11 deletion - which continues to bear fruits until today. He will be deeply missed.
Today, we mourn the loss of Thomas Lehner, PhD, MPH (1960-2024), a pioneering figure in neuropsychiatric genetics and an inspiration to Columbia Psychiatry. Dr. Lehner was known for his warmth, humility, and dedication to diversity in research, leaving an irreplaceable void in
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